Pulse Wave Velocity Is an Independent Predictor of the Longitudinal Increase in Systolic Blood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of Aging

Najjar, Samer S.; Scuteri, Angelo; Shetty, Veena; Wright, Jeanette G.; Muller, Denis C.; Fleg, Jerome L.; Spurgeon, Harold P.; Ferrucci, Luigi; Lakatta, Edward G.

doi:10.1016/j.jacc.2007.10.065

Cited by 425 publications

(306 citation statements)

References 31 publications

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“…However, the recent studies showed that large‐artery stiffness precedes the development of hypertension (Kaess et al., 2012; Najjar et al., 2008). Although hypertension could also contribute to vascular remodeling and stiffening, it is, however, a slow process.…”

Section: Discussionmentioning

confidence: 99%

Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

Chen

Sun

2018

Aging Cell

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Summary DNA methylation increases with age. The objective of this study was to investigate whether compound H, a potential activator of DNA demethylases, attenuates aging‐related arterial stiffness and hypertension. Aged mice (24–27 months) and adult mice (12 months) were used. Pulse wave velocity (PWV), a direct measure of arterial stiffness, and blood pressure (BP) were increased significantly in aged mice. Notably, daily treatments with compound H (15 mg/kg, IP) for 2 weeks significantly attenuated the aging‐related increases in PWV and BP. Compound H abolished aging‐associated downregulation of secreted Klotho (SKL) levels in both kidneys and serum likely by enhancing DNA demethylase activity and decreasing DNA methylation. Aging‐related arterial stiffness was associated with accumulation of stiffer collagen and degradation of compliant elastin which are accompanied by increased expression of MMP2, MMP9, TGF‐β1, and TGF‐β3. These changes were effectively attenuated by compound H, suggesting rejuvenation of aged arteries. Compound H also rescued downregulation of Sirt1 deacetylase, AMPKα, and eNOS activities in aortas of aged mice. In cultured smooth muscle cells (SMCc) Klotho‐deficient serum upregulated expression of MMPs and TGFβ which, however, was not affected by compound H. In conclusion, compound H attenuates aging‐associated arterial stiffness and hypertension by activation of DNA demethylase which increases renal SKL expression and consequently circulating SKL levels leading to activation of the Sirt1‐AMPK‐eNOS pathway in aortas of aged mice.

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Section: Discussionmentioning

confidence: 99%

Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

Chen

Sun

2018

Aging Cell

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“…The correlation of PWV with BMI in hypertensive individuals, as well as the height and waist circumference in hypertensive patients and those with severe renal failure is well known 36 .…”

Section: Discussionmentioning

confidence: 99%

A velocidade da onda de pulso em jovens: estudo do Rio de Janeiro

Pizzi¹,

Brandão²,

Pozzan³

et al. 2011

Arq. Bras. Cardiol.

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“…Third, we did not evaluate other previously proposed predictors of progression from prehypertension and hypertension such as the plasma level of high sensitivity C-reactive protein, a marker of inflammation 22 and the brachial-ankle pulse wave velocity, a marker of arterial stiffness. 23 Finally, our sample was limited to obese multiethnic subjects originated from a university reference center, most of them clustering several cardiometabolic risk factors. Thus, we do not know if the findings can be extended to populations including apparently healthier obese individuals or different ethnic mixtures.…”

Section: Discussionmentioning

confidence: 99%

Hypoadiponectinemia Is Associated With Prehypertension in Obese Individuals of Multiethnic Origin

Celoria¹,

Genelhu²,

Duarte³

et al. 2010

Clinical Cardiology

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Background: Considering that prehypertension is associated with an increase in cardiovascular risk, hypoadiponectinemia seems to be a predictor of hypertension. Hypothesis: This study investigated whether adiponectin plasma levels are affected in Brazilian obese prehypertensives compared with those in normotensives and hypertensives. Methods: The study involved 96 multiethnic obese subjects (mean age = 42.8-11.9 years; BMI= 35.7-7.3 kg/m 2 ). Fasting plasma adiponectin and serum insulin were determined by radioimmunoassay. Insulin resistance was estimated by HOMA-IR. Blood pressure was recorded using a calibrated automated sphygmomanometer. Results: Adiponectin concentrations were significantly lower in prehypertensives compared with those in normotensives, but hypertensives exhibited the lowest adiponectin concentrations of all. Regarding the values of HOMA-IR, both prehypertensives and hypertensives were significantly more insulin resistant when compared with normotensives. When normotensives and prehypertensives were classified according to the 50th percentile of adiponectin (≤ vs > 6.5 mg/ml) a logistic regression was performed to estimate the association of this adipokine with hypertension, the lower the plasma adiponectin values, the greater the association. A multivariate linear regression analysis adjusted for cardiometabolic factors showed that systolic blood pressure increased by 1.612 mm Hg for 1 μg/mL reduction in adiponectin plasma levels (P<0.01). Conclusion: Our findings have shown that hypoadiponectinemia is associated with prehypertension in obese individuals of multiethnic origin. IntroductionThe data from the participants in the Framingham Heart Study demonstrate the increased risk seen in people at any blood pressure (BP) level above optimal (below 120/80 mm Hg) to normal (120-129/80-84 mm Hg) to high normal (130-139/85-89 mm Hg). 1 Over a 12-year followup, the cumulative incidence of cardiovascular events in the enrolled men rose from 6% in those who started as optimal, to 8% in the normal, and 13% in the high normal. In 2003, the Seventh Report of the Joint National Committee (JNC) identified prehypertension as a new category of BP in adults for those with BP from 120 to 139 mm Hg systolic and/or 80 to 89 mm Hg diastolic, encompassing both the normal and high-normal classifications of prior JNC reports. 2 A review of recent published data relating prehypertension to cardiovascular damage includes reports showing an increase in coronary heart disease, cardiac procedure, silent myocardial infarction, or ischemic stroke in middleaged adults followed for an average of 11.6 years, 3 and significant progress of coronary atherosclerosis determined by intravascular ultrasound. 4

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Pulse Wave Velocity Is an Independent Predictor of the Longitudinal Increase in Systolic Blood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of Aging

Cited by 425 publications

References 31 publications

Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

A velocidade da onda de pulso em jovens: estudo do Rio de Janeiro

Hypoadiponectinemia Is Associated With Prehypertension in Obese Individuals of Multiethnic Origin

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