Pulse wave velocity: A clinical measure to aid material parameter estimation in computational arterial biomechanics

Gheysen, Lise; Maes, Lauranne; Famaey, Nele; Segers, Patrick

doi:10.1016/j.jbiomech.2023.111482

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…The parameters were determined based on a predefined value of the pulse wave velocity as proposed in Gheysen et al ( 2023 ), where the pulse wave velocity of a full factorial design of the Gasser-Ogden-Holzapfel (GOH) parameters, including collagen fiber dispersion, was calculated for a reference cylinder. A pulse wave velocity of 6 m/s was assumed, which is representative for the aortic stiffness in middle-aged humans and, thus, corresponds to the average age of dissection patients (Logghe et al 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Growth and remodeling of the dissected membrane in an idealized dissected aorta model

Gheysen,

Maes,

Famaey

et al. 2023

Biomech Model Mechanobiol

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While transitioning from the acute to chronic phase, the wall of a dissected aorta often expands in diameter and adaptations in thickness and microstructure take place in the dissected membrane. Including the mechanisms, leading to these changes, in a computational model is expected to improve the accuracy of predictions of the long-term complications and optimal treatment timing of dissection patients. An idealized dissected wall was modeled to represent the elastin and collagen production and/or degradation imposed by stress- and inflammation-mediated growth and remodeling, using the homogenized constrained mixture theory. As no optimal growth and remodeling parameters have been defined for aortic dissections, a Latin hypercube sampling with 1000 parameter combinations was assessed for four inflammation patterns, with a varying spatial extent (full/local) and temporal evolution (permanent/transient). The dissected membrane thickening and microstructure was considered together with the diameter expansion over a period of 90 days. The highest success rate was found for the transient inflammation patterns, with about 15% of the samples leading to converged solutions after 90 days. Clinically observed thickening rates were found for 2–4% of the transient inflammation samples, which represented median total diameter expansion rates of about 5 mm/year. The dissected membrane microstructure showed an elastin decrease and, in most cases, a collagen increase. In conclusion, the model with the transient inflammation pattern allowed the reproduction of clinically observed dissected membrane thickening rates, diameter expansion rates and adaptations in microstructure, thus providing guidance in reducing the parameter space in growth and remodeling models of aortic dissections.

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Section: Methodsmentioning

confidence: 99%

Growth and remodeling of the dissected membrane in an idealized dissected aorta model

Gheysen,

Maes,

Famaey

et al. 2023

Biomech Model Mechanobiol

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View full text Add to dashboard Cite

show abstract

“…Beyond multi-omics approaches (95,130), cardiovascular modeling and artificial intelligencebased models have been used to generate large databases of virtual subjects. Combining computational databases with machine learning has been used to predict or estimate PWV from pulse wave analysis algorithms (131,132) or from the radial pressure wave measurement (133). It also holds promise for estimating the proximal aortic characteristic impedance and arterial compliance of the arterial system from regional PWV measurements (134).…”

Section: -140mentioning

confidence: 99%

Arterial Stiffness: From Basic Primers to Integrative Physiology

Regnault,

Lacolley,

Laurent

2024

Annu. Rev. Physiol.

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The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we provide new insight into the integrative physiology of arterial stiffening and its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as important basic determinants of arterial stiffness, particularly those mediating the vascular smooth muscle cell (VSMC) contractility, plasticity and stiffness. We focus on membrane and nuclear mechanotransduction, clearance function of the vascular wall, phenotypic switching of VSMCs, immunoinflammatory stimuli and epigenetic mechanisms. Finally, we discuss the most important advances of the latest clinical studies that revisit the classical therapeutic concepts of arterial stiffness and lead to a patient-by-patient strategy according to cardiovascular risk exposure and underlying disease.

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Uncertainty quantification of the wall thickness and stiffness in an idealized dissected aorta

Gheysen,

Maes,

Caenen

et al. 2024

Journal of the Mechanical Behavior of Biomedical Materials

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Pulse wave velocity: A clinical measure to aid material parameter estimation in computational arterial biomechanics

Cited by 3 publications

References 33 publications

Growth and remodeling of the dissected membrane in an idealized dissected aorta model

Growth and remodeling of the dissected membrane in an idealized dissected aorta model

Arterial Stiffness: From Basic Primers to Integrative Physiology

Uncertainty quantification of the wall thickness and stiffness in an idealized dissected aorta

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