Pulse Wave Imaging for Noninvasive and Quantitative Measurement of Arterial Stiffness In Vivo

Vappou, Jonathan; Luo, Jianwen; Konofagou, Elisa E.

doi:10.1038/ajh.2009.272

Cited by 136 publications

(121 citation statements)

References 30 publications

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“…Shear rheometry testing was initially performed on small cylindrical samples (diameter d ¼ 6.68 6 0.44 mm and height h ¼ 4.20 6 0.52 mm) from phantoms of 15%, 20%, 25%, 30%, 45%, 60%, and 75% polyacrylamide (Fisher Scientific, PA, USA) gel concentrations (n ¼ 3 for each) [10], in order to characterize the wall mechanical properties. The mechanical testing results were used to determine the gel concentrations which yield the desired Young's modulus of 110 kPa (reported for canine aorta in vitro) as well as lower and higher moduli of 55 and 220 kPa, respectively, representing softer and stiffer walls.…”

Section: Canine Aortamentioning

confidence: 99%

“…More recently, the ultrasound-based method of pulse wave imaging (PWI) has been developed to fully analyze the wave propagation with high temporal and spatial resolutions and to measure the PWV locally. The PWI feasibility studies have been done in various applications such as normal and aneurysmal mouse [17] and human aortas [18], aneurysmal and hypertensive patients [19], and experimental aortic phantoms [10]. The PWI results have also been compared against the clinical method of applanation tonometry in humans [20].…”

Section: Introductionmentioning

confidence: 99%

“…Such methods are at the core of most clinical studies involving the measurement of arterial stiffness [9]. Due to a number of factors, such as the lack of knowledge on the exact arterial geometry and the assumption of a single longitudinal flow direction between the carotid and the femoral sites, such methods may lead to an overestimation/underestimation of the true distance [10]. Most importantly, the wall stiffness has been shown to vary along the arterial tree, and therefore assuming a global PWV may not detect early onset or focal disease [11].…”

Section: Introductionmentioning

confidence: 99%

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Pulse-Wave Propagation in Straight-Geometry Vessels for Stiffness Estimation: Theory, Simulations, Phantoms and In Vitro Findings

Shahmirzadi

Konofagou

2012

Journal of Biomechanical Engineering

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Pulse wave imaging (PWI) is an ultrasound-based method for noninvasive characterization of arterial stiffness based on pulse wave propagation. Reliable numerical models of pulse wave propagation in normal and pathological aortas could serve as powerful tools for local pulse wave analysis and a guideline for PWI measurements in vivo. The objectives of this paper are to (1) apply a fluidstructure interaction (FSI) simulation of a straight-geometry aorta to confirm the Moens-Korteweg relationship between the pulse wave velocity (PWV) and the wall modulus, and (2) validate the simulation findings against phantom and in vitro results. PWI depicted and tracked the pulse wave propagation along the abdominal wall of canine aorta in vitro in sequential Radio-Frequency (RF) ultrasound frames and estimates the PWV in the imaged wall. The same system was also used to image multiple polyacrylamide phantoms, mimicking the canine measurements as well as modeling softer and stiffer walls. Finally, the model parameters from the canine and phantom studies were used to perform 3D two-way coupled FSI simulations of pulse wave propagation and estimate the PWV. The simulation results were found to correlate well with the corresponding Moens-Korteweg equation. A high linear correlation was also established between PWV 2 and E measurements using the combined simulation and experimental findings (R 2 ¼ 0.98) confirming the relationship established by the aforementioned equation.

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Section: Canine Aortamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pulse-Wave Propagation in Straight-Geometry Vessels for Stiffness Estimation: Theory, Simulations, Phantoms and In Vitro Findings

Shahmirzadi

Konofagou

2012

Journal of Biomechanical Engineering

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“…The CCA is an interesting target: the artery surfaces at an easily accessible place, distance between measurement sites can be readily measured, pulse wave will be minimally changed over short assessed distances, it is often affected by atherosclerosis, and augmented stiffness of the CCA is believed to cause hypertrophy of the heart due to the wave reflections at the bifurcation. 33 Several noninvasive methods focus on the PWV detection in the CCA, such as pulse wave imaging (PWI), 16 and LDV. 17,34 Temporal resolution of reported PWI studies is often rather low (order of several 100 Hz), and LDV has a limited amount of measurement points (two measurement points when two Fig.…”

Section: Discussionmentioning

confidence: 99%

Digital image correlation for full-field time-resolved assessment of arterial stiffness

et al. 2014

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Abstract. Pulse wave velocity (PWV) of the arterial system is a very important parameter to evaluate cardiovascular health. Currently, however, there is no golden standard for PWV measurement. Digital image correlation (DIC) was used for full-field time-resolved assessment of displacement, velocity, acceleration, and strains of the skin in the neck directly above the common carotid artery. By assessing these parameters, propagation of the pulse wave could be tracked, leading to a new method for PWV detection based on DIC. The method was tested on five healthy subjects. As a means of validation, PWV was measured with ultrasound (US) as well. Measured PWV values were between 3.68 and 5.19 m∕s as measured with DIC and between 5.14 and 6.58 m∕s as measured with US, with a maximum absolute difference of 2.78 m∕s between the two methods. DIC measurements of the neck region can serve as a test base for determining a robust strategy for PWV detection, they can serve as reference for three-dimensional fluid-structure interaction models, or they may even evolve into a screening method of their own. Moreover, full-field, time-resolved DIC can be adapted for other applications in biomechanics.

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“…The use of multi-line wallmotion systems allows measurement of the distension produced by the pressure wave over a short segment of the artery, which in turn allows the local PWV to be estimated. [52][53][54][55] Several studies have measured wall motion and stiffness indices in patients and volunteers. With increasing age or diabetes the stiffness of the aorta increases (E and E p ).…”

Section: 33mentioning

confidence: 99%

Recent developments in vascular ultrasound technology

Kenwright

2015

Ultrasound

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This article describes four technologies relevant to vascular ultrasound which are available commercially in 2015, and traces their origin back through the research literature. The technologies are 3D ultrasound and its use in plaque volume estimation (first described in 1994), colour vector Doppler for flow visualisation (1994), wall motion for estimation of arterial stiffness (1968), and shear wave elastography imaging of the arterial wall (2010). Overall these technologies have contributed to the understanding of vascular disease but have had little impact on clinical practice. The basic toolkit for vascular ultrasound has for the last 25 years been real-time B-mode, colour flow and spectral Doppler. What has changed over this time is improvement in image quality. Looking ahead it is noted that 2D array transducers and high frame rate imaging continue to spread through the commercial vascular ultrasound sector and both have the potential to impact on clinical practice.

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Pulse Wave Imaging for Noninvasive and Quantitative Measurement of Arterial Stiffness In Vivo

Cited by 136 publications

References 30 publications

Pulse-Wave Propagation in Straight-Geometry Vessels for Stiffness Estimation: Theory, Simulations, Phantoms and In Vitro Findings

Pulse-Wave Propagation in Straight-Geometry Vessels for Stiffness Estimation: Theory, Simulations, Phantoms and In Vitro Findings

Digital image correlation for full-field time-resolved assessment of arterial stiffness

Recent developments in vascular ultrasound technology

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