Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives

Abstract

Background:First-degree relatives (FDRs) of hypertensive (HT) are predisposed to hypertension (HTN) which accelerates cardiovascular aging. Same can be studied noninvasively by pulse wave analysis (PWA), encompassing central hemodynamics such as central blood pressure (cBP), cardiac output, and stroke work (SW) and vascular stiffness parameters such as pulse wave velocity (PWV) and augmentation index at HR 75 (AIx@75). We studied PWA-derived cardiovascular parameters in FDRs of HT compared to controls.Materials and Methods:We conducted a case–control study in 119 FDRs of HT and 119 matched controls. Oscillometric PWA was performed by Mobil-o-Graph (IEM, Germany) and cardiovascular parameters were compared. P < 0.05 was considered statistically significant.Results:Groups were comparable with gender, age, height, weight, body mass index, and physical activity. FDRs of HT had significantly higher brachial and cBPs, SW (101.41 ± 25.44 vs. 88.31 ± 20.25, P = 0.001), rate pressure product-119.40 ± 25.34 vs. 108.34 ± 18.17, P < 0.0001), PWV (5.22 ± 0.46, P < 0.0001), and AIx@75 (31.48 ± 9.01 vs. 27.95 ± 9.4, P = 0.002) than control. Dependent study variables correlated with brachial blood pressure more in magnitude and significance level than age or anthropometric variables. PWA results of FDR with maternal inheritance did not differ significantly from those with paternal inheritance.Conclusion:PWA reveals early cardiovascular aging in young FDRs of HTs. It clues to future cardiovascular disease including HTN itself, need for primary prevention, and further study for consolidation of these results.

Abnormal sympathetic functioning is linked to familial hypertension in nonathletic young males

“…[ 25 ] Using the same instrument in our population, we found higher central hemodynamics in young aged first-degree relatives of hypertensives. [ 26 ] In both these studies,[ 25 26 ] alike this study, positive family history of diabetes or HTN rather than PA was a significant factor. These results support our observation but with respect to other parameters of cardiovascular health.…”

Central hemodynamics and arterial stiffness by oscillometric pulse-wave analysis in treated Gujarati euglycemic hypertensives: A case-control study

“…PWA offers a better understanding of the same, and with the availability of devices like Mobil-O-graph, it has the potential to be applicable and studied further. In our two studies,[928] we found that PWA parameters were significantly higher in apparently healthy, normotensive, young, nonobese offspring of the diabetic or hypertensive parent. This suggests that PWA parameters like arterial stiffness can help in early diagnosis and a better understanding of disease course.…”

Central hemodynamics and arterial stiffness in Gujarati diabetics not receiving any antihypertensive: A case–control study based on oscillometric pulse wave analysis

“…and Chang[22] et al . In previous studies, we found that arterial stiffness was significantly raised in young first-degree relatives of diabetic[6] or hypertensive[7] parents and so the vascular change may precede the incident diabetes or hypertension. It supports the idea that diabetes is more a disease affecting cardiovascular health with hyperglycemia being a late manifestation.…”

“…The pattern of predictors was similar to our previous PWA studies. [6710111627] The major points were as follows: (1) most outcome parameters were not significantly predicted by age (except PWV), height, weight, and BMI; (2) most of these were independent of bBPs pointing toward superiority of these parameters to complement routinely measured objective bBP; (3) HR proved to be the most consistent predictor which normally one can infer from pulse examination and proves the potential of details that can be obtained by arterial pulse examination; and (4) cBPs were not predicted significantly by the corresponding brachial artery values showing its importance beyond bBP.…”

“…Aortic blood pressure, central hemodynamics, and arterial stiffness overcome these limitations. [67] Pulse wave analysis (PWA)–based devices like Mobil-O-Graph provide an opportunity to measure the same. We performed PWA study in type 2 diabetics not receiving antihypertensive medication.…”