Pulse Wave Analysis is a Reproducible Technique for Non-invasive Measurement of Central Blood Pressure and Wave Reflection During Exercise

Richmond, John

doi:10.1016/j.hlc.2007.06.410

Cited by 1 publication

(2 citation statements)

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“…Therefore, some differences in the true central pressures would be expected, particularly because the radial waveform was calibrated by brachial cuff BP. However, we have shown the tonometric central BP technique to be highly reproducible 30 and to correlate closely with invasive central pressures during exercise. 29 The study was also performed in a small group of healthy men, and the findings may not be applicable to larger populations or patient groups.…”

Section: Limitationsmentioning

confidence: 92%

“…A central (ascending aortic) pressure waveform was synthesized from the radial pressure waveform using a transfer function validated, and shown to have excellent reproducibility, during exercise. 29,30 AIx, a composite measure of wave reflection and systemic arterial stiffness was calculated on the radial and central pressure waveforms by the difference between the second and first systolic peaks, expressed as a percentage of the PP. 31 The estimated aortic pulse wave velocity (T R ) was calculated as the time between the foot of the pressure wave and the first inflection point and has been shown to correlate with aortic pulse wave velocity.…”

Section: Hemodynamicsmentioning

confidence: 99%

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Nitric Oxide Does Not Significantly Contribute to Changes in Pulse Pressure Amplification During Light Aerobic Exercise

et al. 2008

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Abstract-NO modulates resting blood pressure and wave reflection. The effect of NO on exercise central hemodynamics is unknown but has important implications relating to cardiovascular risk. The aim of this study was to determine the contribution of NO to pulse pressure (PP) amplification and wave reflection during exercise. Twelve healthy men aged 29Ϯ1 years (meanϮSEM) undertook cycle exercise at 60% of their maximal heart rate. Noninvasive measures of central blood pressure, estimated aortic pulse wave velocity, and wave reflection (augmentation index) were obtained by pulse wave analysis during intravenous infusion of saline (control), N G -monomethyl-L-arginine (a NO-synthase inhibitor), or noradrenaline (control vasoconstrictor). PP amplification was defined as the ratio of peripheral to central PP. Cardiac output and stroke volume were determined by electric bioimpedance. Both N G -monomethyl-L-arginine and noradrenaline caused a significant increase in mean arterial pressure (PϽ0.01) and augmentation index (PϽ0.01), as well as reduced ratio of peripheral to central PP (PϽ0.05) at baseline. Exercise caused a significant increase in the ratio of peripheral to central PP (PϽ0.001), whereas augmentation index and estimated aortic pulse wave velocity declined (for both PϽ0.05) during all 3 of the infusion protocols. However, no significant differences were observed in augmentation index, ratio of peripheral to central PP, or estimated aortic pulse wave velocity between infusion procedures (PϾ0.50) during exercise. Also, heart rate, peripheral vascular resistance, and cardiac output did not differ during exercise between saline, N G -monomethyl-L-arginine, or noradrenaline. Although we cannot rule out other vasodilator mechanisms having adjusted for NO blockade, our results indicate that NO does not solely contribute to systemic arterial stiffness or altered blood pressure amplification during light exercise.

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Section: Limitationsmentioning

confidence: 92%

Section: Hemodynamicsmentioning

confidence: 99%