Pulse-spray Pharmacomechanical Thrombolysis for Proximal Deep Vein Thrombosis

Abstract

The combination of pulse-spray pharmacomechanical thrombolysis and the prophylactic use of a non-permanent IVC filter was a safe and effective approach for treating acute proximal DVT.

Inferior vena cava thrombosis: A review of current practice

“…Similar to other types of venous thromboembolus (VTE), immediate treatment strategies for IVC thrombosis revolve around minimising the risk of pulmonary embolisation and reducing the local sequelae of lower limb swelling and pain. 7,65 Medical, endovascular and surgical options are available. Long-term goals are to prevent symptoms and signs of CVI and minimise or prevent PTS.…”

“…Long-term goals are to prevent symptoms and signs of CVI and minimise or prevent PTS. 65 The 2012 guidelines for antithrombotic therapy of VTE from the American College of Chest Physicians (ACCP) recommend, for patients with acute DVT, low-molecular weight heparin (LMWH) or fondaparinux over intravenous unfractionated heparin (IV UFH) (Grade 2C evidence) and over subcutaneous UFH (SC UFH) (Grade 2B evidence for LMWH; Grade 2C for fondaparinux). These recommendations, though largely based on lower limb DVT, include the treatment of IVC thrombosis.…”

Early and Long-Term Outcomes of Venous Stent Implantation for Iliac Venous Stenosis After Catheter-Directed Thrombolysis for Acute Deep Vein Thrombosis

“…Catheter-directed thrombolysis was not performed, but antico- bolysis is being increasingly used to treat DVT and venous disease. 7 Stent implantation for venous stenosis is a catheter intervention for venous disease and is considered to be an effective treatment for venous stagnation. In our hospital, venous stents are implanted in patients with venous stasis because of severe stenosis after complete thrombolysis.…”

The Günther-Tulip Retrievable IVC Filter

“…In principle, 240,000 units of urokinase, the only thrombolytic able to be used for the treatment of VTE in Japan at the time this study started, were administered systemically or catheterdirectly, 3 times per day. 19 Ascending venography, venous ultrasonography, or enhanced CT was used every 1-3 days for observation, which enabled the treatment to be suspended until reduction or elimination of the DVT occurred.…”