Pulse radiolytic study of electron transfer reaction for fast repair of the one-electron oxidized radicals of dAMP and dGMP by hydroxycinnamic acid derivatives

Jiang, Yue; Wang, Lin; Yao, Side; Lin, Nianyun; Zhu, Da‐Yuan

doi:10.1016/s0969-806x(98)00220-5

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…8 Electron transfer from dGMP to the oxidized radical of riboflavin, studied using laser flash photolysis, [9][10][11] provided an imperative pathway to DNA damage both in vivo and in vitro. Fast electron repair of oxidizing OH adducts of dGMP by various acid derivatives, studied using pulse radiolysis, [12][13][14] is welldocumented in the literature. Synthetic and spectroscopic studies of dGMP complexes with Pt(II), Mg(II) 15 and with other metal ions 16 have been topics of interest for chemists during the past decade.…”

Section: Introductionmentioning

confidence: 99%

Investigations of electron-transfer reactions and the redox mechanism of 2′-deoxyguanosine-5′-monophosphate using electrochemical techniques

2005

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Section: Introductionmentioning

confidence: 99%

Investigations of electron-transfer reactions and the redox mechanism of 2′-deoxyguanosine-5′-monophosphate using electrochemical techniques

2005

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“…Bond dissociation energies and ionization potentials for trans -resveratrol have been estimated in both a gas phase and in an aqueous solution. − It has been found that its bond dissociation energies were lower than its ionization potentials. The repair activities of silybin, hydroxycinnamic acid derivatives, quercetin, and rutin toward dGMP hydroxyl adduct radicals have also been investigated experimentally. It has been shown that polyphenols have high reactivity toward DNA adduct radicals with approximate diffusion controlled rates of 10 8 to 10 9 dm 3 mol –1 s –1 .…”

Section: Introductionmentioning

confidence: 99%

Repair Activity of trans-Resveratrol toward 2′-Deoxyguanosine Radicals

Cheng¹,

An²,

et al. 2018

J. Phys. Chem. B

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In the present study, the repair activity of trans-resveratrol toward 2'-deoxyguanosine (dGuo) radicals in polar and nonpolar solvents was studied using density functional theory. The hydrogen transfer/proton coupled electron transfer and single electron transfer (SET) mechanisms between trans-resveratrol and dGuo-radicals were considered. Taking into consideration the molar fraction of neutral trans-resveratrol (ROH) and anionic trans-resveratrol (RO), the overall rate constants for repairing dGuo-radicals by trans-resveratrol are 9.94 × 10 and 2.01 × 10 dm mol s in polar and nonpolar solvents, respectively, and the overall rate constant of repairing cation radical (dGuo) by trans-resveratrol via an SET mechanism is 7.17 × 10 dm mol s. The repair activity of RO toward dGuo-radicals is better than that of ROH, but the repair activity of ROH toward dGuo is better than that of RO. Unfortunately, neither ROH nor RO can repair the 2'-deoxyribose radicals of dGuo. It can therefore be concluded that trans-resveratrol is an effective antioxidant for repairing base radicals of dGuo and dGuo. The study can help us understand the repair activity of trans-resveratrol toward dGuo radicals.

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Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals

Santos¹,

Vieira

2013

J. Phys. Org. Chem.

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Cinnamic acid and its derivatives react with hydroxyl radical (HO ), in neutral medium, to give hydroxylation products, whether on the benzene ring or on the exocyclic chain, and decarboxylation products. The latter compounds are also obtained after oxidation of the same substrates by the SO 4 À radical anion. Evidence was provided for the protecting effects afforded by cinnamic acid and hydroxylated derivatives against oxidative reaction mediated by HO . By using adenine as a model compound, the results obtained suggest that the high protective effect is due to an antioxidising cascade process.

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Pulse radiolytic study of electron transfer reaction for fast repair of the one-electron oxidized radicals of dAMP and dGMP by hydroxycinnamic acid derivatives

Cited by 7 publications

References 17 publications

Investigations of electron-transfer reactions and the redox mechanism of 2′-deoxyguanosine-5′-monophosphate using electrochemical techniques

Investigations of electron-transfer reactions and the redox mechanism of 2′-deoxyguanosine-5′-monophosphate using electrochemical techniques

Repair Activity of trans-Resveratrol toward 2′-Deoxyguanosine Radicals

Antioxidising activity of cinnamic acid derivatives against oxidative stress induced by oxidising radicals

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