Pulse pressure and coronary atherosclerosis in asymptomatic type 2 diabetes mellitus: A 64 channel cardiac computed tomography analysis

Halon, David A.; Dobrecky‐Mery, Idit; Gaspar, Tamar; Azencot, Mali; Yaniv, Nisan; Peled, Nathan; Lewis, Basil S.

doi:10.1016/j.ijcard.2009.01.066

Cited by 8 publications

(6 citation statements)

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“…For example, the Framingham Heart Study showed that pulse pressure, a surrogate measure of arterial stiffness, is a better predictor of coronary heart disease risk than either systolic or diastolic blood pressure, at least among people aged > 50 years, whereas the opposite seems to apply in younger people. The independent value of pulse pressure in predicting mortality among people with Type 2 diabetes has also been shown previously .…”

Section: Discussionsupporting

confidence: 73%

Association between pulse pressure and risk of hospital admissions for cardiovascular events among people with Type 2 diabetes: a population‐based case–control study

Simmons

2015

Diabet. Med.

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Section: Discussionsupporting

confidence: 73%

Association between pulse pressure and risk of hospital admissions for cardiovascular events among people with Type 2 diabetes: a population‐based case–control study

Simmons

2015

Diabet. Med.

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“…In addition, a study by Halon et al, focused on the relationship between pulse pressure and subclinical disease. [28] They found that elevated pulse pressure was an independent marker of the presence of pre-clinical coronary artery disease in an asymptomatic diabetic population, using 64-channel cardiac computed tomography analysis. Although the instruments for detection were not the same, both studies showed that pulse pressure can be an early clinical clue of asymptomatic atherosclerosis in coronary or peripheral circulation.…”

Section: Discussionmentioning

confidence: 99%

Pulse pressure and michigan neuropathy screening instrument are independently associated with asymptomatic peripheral arterial disease among type 2 diabetes community residents: A community-based screening program in Taiwan

Fan¹,

Chen²,

Huang³

et al. 2013

Biomed J

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“…30 Halon et al have recently reported a relationship between brachial pulse pressure and the extent of coronary atherosclerosis in asymptomatic patients with diabetes; in that study, coronary atherosclerosis was quantified by cardiac computed tomography. 31 …”

Section: Discussionmentioning

confidence: 99%

Aortic Pulse Pressure Is Associated With the Localization of Coronary Artery Disease Based on Coronary Flow Lateralization

et al. 2012

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Hypertension has a major impact on cardiovascular and renal mortality and morbidity, with a 90% lifetime risk of developing hypertension. 1 Optimal blood pressure control reduces the risk of stroke by 38% and of myocardial infarction by 16%. 2 Compared to peripheral arterial pressure measurements, aortic pressures were shown to better predict coronary artery disease (CAD) 3,4 and cardiovascular risk. 5 Brachial arterial pressure does not correctly reflect aortic pressure, especially its systolic component, due to pulse pressure amplification. 6,7 It is also important to mention that central (aortic) pressures are the pressures directly affecting coronary and cerebral circulations, as well as the left ventricle, much more than pressures measured in the arm, and the latter is of paramount importance in end-organ damage related to hypertension. 8 Several ascending aortic blood pressure indices were studied, among which aortic pulse pressure (APP) correlated with increased cardiovascular complications. 9 Moreover, a higher APP was associated with more extensive CAD at time of coronary angiography. 10 A recent large prospective study has shown the superiority of central (aortic) over peripheral (brachial) pressures, as well as the superiority of APP and pulsatility over mean pressure in predicting adverse cardiovascular events. 11 Higher APP is related to arterial stiffness, a feature of aging and multiple cardiovascular conditions. 7 Although arterial stiffening is thought to represent by itself a form of cardiovascular end-organ damage, 7 and although APP is only an indirect indicator of arterial stiffness, higher APP may link arteriosclerosis (arterial stiffening) to other forms of end-organ damage such as atherosclerosis. The role of cyclical stretch due to pulsatile pressure in atherosclerosis is recognized. 12 BackgroundAortic pulse pressure (APP) is related to arterial stiffness and associated with the presence and extent of coronary artery disease (cAD). Besides, the left coronary artery (LcA) has a predominantly diastolic flow while the right coronary artery (RcA) receives systolic and diastolic flow. thus, we hypothesized that increased systolicdiastolic pressure difference had a greater atherogenic effect on the RcA than on the LcA.

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Pulse pressure and coronary atherosclerosis in asymptomatic type 2 diabetes mellitus: A 64 channel cardiac computed tomography analysis

Cited by 8 publications

References 50 publications

Association between pulse pressure and risk of hospital admissions for cardiovascular events among people with Type 2 diabetes: a population‐based case–control study

Association between pulse pressure and risk of hospital admissions for cardiovascular events among people with Type 2 diabetes: a population‐based case–control study

Pulse pressure and michigan neuropathy screening instrument are independently associated with asymptomatic peripheral arterial disease among type 2 diabetes community residents: A community-based screening program in Taiwan

Aortic Pulse Pressure Is Associated With the Localization of Coronary Artery Disease Based on Coronary Flow Lateralization

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