Pulse oximetry as a screening test for congenital heart defects in newborn infants: a test accuracy study with evaluation of acceptability and cost-effectiveness.

Abstract

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Oxygen Saturation Nomogram in Newborns Screened for Critical Congenital Heart Disease

“…We followed the de-Wahl Granelli method of screening both pre-and postductal saturations to increase the detection of CCHD cases and justified the minimal added cost. 4,19 In our study, 91 newborns required a repeat screen, 75% of which were triggered by a .3% difference; 90% passed the repeat screen. The number of CCHD cases in our study is too small to make any argument regarding single postductal versus pre-and postductal screens.…”

“…Pulse oximetry screening can be used to identify CCHD in asymptomatic newborns to lessen the burden of undiagnosed CCHD. [3][4][5] Multiple studies have evaluated different screening methodologies including postductal oxygen saturation measurements alone, [6][7][8][9] or both pre-and postductal 4,10 saturations. There are also considerable differences in both the timing of screening (from 4 to 24-72 hours after birth) [6][7][8][9][10] and the threshold values (from #92% to #96%).…”

Implementation of Critical Congenital Heart Disease Screening in Minnesota

“…[1][2][3][4][5] In September 2011, the US Secretary of Health and Human Services approved inclusion of newborn screening for CCHD to the Recommended Uniform Screening Panel. The addition of this screening tool to the Recommended Uniform Screening Panel provides the opportunity to improve the outcomes of children born with CCHD.…”

A Single-Extremity Staged Approach for Critical Congenital Heart Disease Screening: Results from Tennessee

“…We did not systematically track all the babies who failed and who did not have CCHD, but we found a case of intracranial hemorrhage with apnea, a nasal lacrimal tumor, several babies with pneumonia and sepsis. It is clear that no baby should be discharged with a saturation of less than 95% without a clinical diagnosis [11].…”