Pulse low-intensity electromagnetic field as prophylaxis of heterotopic ossification in patients with traumatic spinal cord injury

Đurović, Aleksandar; Miljković, Dejan; Brdareski, Zorica; Plavšić, Aleksandra; Jevtic, Miodrag

doi:10.2298/vsp0901022d

Cited by 13 publications

(13 citation statements)

References 23 publications

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“…There were 13 studies that met the inclusion criteria; this included four prophylaxis 1,3,22,23 and nine treatment [24][25][26][27][28][29][30][31][32][33][34][35] studies of HO. Three of these intervention studies had Level 1,3,22,23 two Level 2, 24,25 seven Level 4 [26][27][28][29][32][33][34][35] and one Level 5 1 evidence.…”

Section: Resultsmentioning

confidence: 99%

“…Three of these intervention studies had Level 1,3,22,23 two Level 2, 24,25 seven Level 4 [26][27][28][29][32][33][34][35] and one Level 5 1 evidence.…”

Section: Resultsmentioning

confidence: 99%

“…Only three of the interventional studies reviewed were rated as high-quality RCTs. 3,22,23 Two of these RCTs evaluated NSAIDs, 3,22 whereas one showed the effectiveness of PLIMF therapy in the prevention of HO. 23 Treatment studies tended to involve smaller numbers of patients and were of lower quality when compared with prevention studies.…”

Section: Discussionmentioning

confidence: 99%

“…Pulse low-intensity electromagnetic field (PLIMF) therapy uses magnetic fields to increase oxygen levels and decrease toxic by-products of inflammation by increasing local blood flow into the area. 23 Durovic et al 23 conducted an RCT examining the effect of PLIMF therapy as a prophylaxis for HO in individuals with SCI. Diagnosis of HO was through plain radiography and the Brooker's grading system.…”

Section: Prophylaxis Of Homentioning

confidence: 99%

“…23 Treatment of HO Bisphosphates. Six studies reported on the efficacy of bisphosphonates in the treatment of HO, once diagnosed (Table 3).…”

Section: Prophylaxis Of Homentioning

confidence: 99%

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A systematic review of the therapeutic interventions for heterotopic ossification after spinal cord injury

et al. 2010

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Study design: Systematic review. Objective: To conduct a systematic review of the effectiveness of interventions used to prevent and treat heterotopic ossification (HO) after spinal cord injury (SCI). Setting: St Joseph's Parkwood Hospital, London, Ontario, Canada. Methods: MEDLINE, CINAHL, EMBASE and PsycINFO databases were searched for articles addressing the treatment of HO after SCI. Studies were selected by two reviewers and were only included for analysis if at least 50% of the subjects had an SCI, there were at least three SCI subjects and if the study subjects participated in a treatment or intervention. Study quality was assessed by two independent reviewers using the Downs and Black evaluation tool for all studies, as well as the PEDro assessment scale for randomized control trials only. Levels of evidence were assigned using a modified Sackett scale. Results: A total of 13 studies met the inclusion criteria. The selected articles were divided into prevention or treatment of post-SCI HO. Nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, and pulse low-intensity electrogmagnetic field (PLIMF) therapy were reviewed as prophylactic measures. Bisphosphonates, radiotherapy and excision were reviewed as treatments of post-SCI HO. Conclusions: Pharmacological treatments of HO after SCI had the highest level of research evidence supporting their use. Of these, NSAIDs showed greatest efficacy in the prevention of HO when administered early after an SCI, whereas bisphosphonates were the intervention with strongest supportive evidence once HO had developed. Of the non-pharmacological interventions, PLIMF was supported by the highest level of evidence; however, more research is needed to fully understand its role.

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Section: Resultsmentioning

confidence: 99%

“…Three of these intervention studies had Level 1,3,22,23 two Level 2, 24,25 seven Level 4 [26][27][28][29][32][33][34][35] and one Level 5 1 evidence.…”

Section: Resultsmentioning

confidence: 99%