Pulse galvanostatic electrodeposition of biosurfactant assisted brushite-hydroxyapatite coatings on 316 L stainless steel with enhanced electrochemical and biological properties

Prasad, P. Siva; Hazra, Chinmay; Jena, Sambedan; Byram, Prasanna Kumar; Sen, Ramkrishna; Chakravorty, Nishant; Das, Siddhartha; Das, Karabi

doi:10.1016/j.colsurfa.2023.131651

Cited by 3 publications

(2 citation statements)

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“…00-011-0293). As shown in Figure a, the peak intensity decreases and broadness slightly increases when the Cu concentration increases from 0.002 to 0.02 M. Further, the XRD peaks of Cu-doped coatings without BS have low intensity (as shown in Figure b) compared to the coatings with BS, indicating that the addition of BS promotes the growth of the brushite phase as discussed in the earlier work …”

Section: Resultsmentioning

confidence: 58%

“…In our previous investigation, we examined the effect of different concentrations of BS (15, 25, and 50 mg/L) on structural, electrochemical, and biological properties. The results led us to identify the optimal BS concentration of 25 mg/L, which exhibited the desired properties . Building upon this knowledge, our current study focuses on synthesizing brushite coatings doped with Cu with the assistance of 25 mg/L of BS to observe the combined effects of Cu and the BS on the structure and electrochemical (corrosion) and biological properties.…”

Section: Introductionmentioning

confidence: 99%

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Biosurfactant-Assisted Cu Doping of Brushite Coatings: Enhancing Structural, Electrochemical, and Biofunctional Properties

Siva Prasad,

Byram,

Hazra

et al. 2024

ACS Appl. Mater. Interfaces

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Stainless steel (316L SS) has been widely used in orthopedic, cardiovascular stents, and other biomedical implant applications due to its strength, corrosion resistance, and biocompatibility. To address the weak interaction between steel implants and tissues, it is a widely adopted strategy to enhance implant performance through the application of bioactive coatings. In this study, Cu-doped brushite coatings were deposited successfully through pulse electrodeposition on steel substrates facilitated with a biosurfactant (BS) (i.e., surfactin). Further, the combined effect of various concentrations of Cu ions and BS on the structural, electrochemical, and biological properties was studied. The X-ray diffraction (XRD) confirms brushite composition with Cu substitution causing lattice contraction and a reduced crystallite size. The scanning electron microscopy (SEM) and energydispersive spectroscopy (EDS) studies reveal the morphological changes of the coatings with the incorporation of Cu, which is confirmed by X-ray photoelectron spectroscopy (XPS) and elemental mapping. The Fourier transform infrared (FTIR) and Raman spectroscopy confirm the brushite and Cu doping in the coatings, respectively. Increased surface roughness and mechanical properties of Cu-doped coatings were analyzed by using atomic force microscopic (AFM) and nanohardness tests, respectively. Electrochemical assessments demonstrate corrosion resistance enhancement in Cu-doped coatings, which is further improved with the addition of biosurfactants. In vitro biomineralization studies show the Cu-doped coating's potential for osseointegration, with added stability. The cytocompatibility of the coatings was analyzed using live/dead and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assays; cell adhesion, proliferation, and migration studies were evaluated using SEM. Antibacterial assays highlight significant improvement in the antibacterial properties of Cu-doped coatings with BS. Thus, the developed Cudoped brushite coatings with BS demonstrate their potential in the realm of biomedical implant technologies, paving the way for further exploration.

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Section: Resultsmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%