Pulsating aerosols for drug delivery to the sinuses in healthy volunteers

Möller, Winfried; Schuschnig, Uwe; Saba, Gülnaz Khadem; Meyer, Gabriele; Junge-Hülsing, B.; Keller, Manfred; Häußinger, K.

doi:10.1016/j.otohns.2009.12.028

Cited by 61 publications

(67 citation statements)

References 14 publications

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“…For the prevention of the colonization of the donor lung with P. aeruginosa from the sinonasal segment, we instructed the patient to continuously inhale Colomycin 1 MIU twice daily into the lower airways and to administer Colomycin 1 MIU once daily into the upper airways (UAW). The utilized device is the Pari Sinus™ nebulizer which has been shown to deposit vibrating aerosols into the paranasal sinuses [2,3]. …”

Section: Case Reportsmentioning

confidence: 99%

Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation

Mainz

Hentschel

Schien

et al. 2012

Journal of Cystic Fibrosis

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Pulmonary colonization of transplanted donor lungs with identical clones previously colonizing the explanted lungs has been described previously and the upper airways were postulated as reservoir for descending colonization. However, this remained speculative, as upper airway sampling which does not belong to current standards, was not performed in these studies. Our report demonstrates persistence of identical P. aeruginosa genotypes in CF upper airways prior to and after LTX underlining risks of descending colonization of transplanted lungs with P. aeruginosa, which increases risks of graft dysfunction. Therefore, we recommend regular assessment of sinonasal colonization prior to and after LTX. Sinonasal inhalation with antimicrobials should be investigated in prospective trials.

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Section: Case Reportsmentioning

confidence: 99%

Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation

Mainz

Hentschel

Schien

et al. 2012

Journal of Cystic Fibrosis

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“…An alternative to this could be Xenon-enhanced computed tomography (CT) or measurement of radionuclide deposition, both of which have been previously reported in the literature. 9,15 Last, given use of cadaver heads, no direct statements are possible about the potential role of the device in the clinical setting. Clinical trials in normal subjects and CRS patients (unoperated and operated) would be required, preferably with nebulized topical medications, to better evaluate the clinical relevance of the powered nebulizer.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9] Preliminary studies with nebulized antibiotics have demonstrated improvement in both symptom and endoscopic parameters, with longer infection-free period. 10,11 Despite the frequent use of nebulized therapies for CRS, there is a relative paucity of studies assessing deposition of aerosol within the nose and paranasal sinuses.…”

Section: Rhinosinusitis (Crs)mentioning

confidence: 99%

Prospective evaluation of aerosol delivery by a powered nasal nebulizer in the cadaver model

Manes

Tong

Batra

2011

Int Forum Allergy Rhinol

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“…15 Among the strategies employed to minimize exhalation losses, intermittent aerosol drug delivery has been used for numerous applications such as intermittent positive-pressure ventilation and drug delivery to the sinuses. [16][17][18][19] Using intermittent aerosol delivery, aerosol is delivered only during the inhalation portion of the breathing cycle to minimize exhalation losses. However, the effectiveness of this method has been controversial and has not been obvious in all applications.…”

Section: What This Paper Contributes To Our Knowledgementioning

confidence: 99%

Intermittent Aerosol Delivery to the Lungs During High-Flow Nasal Cannula Therapy

Golshahi¹,

Longest²,

Azimi³

et al. 2014

Respir Care

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INTRODUCTION:Use of submicrometer particles combined with condensational growth techniques has been proposed to reduce drug losses within components of high-flow nasal cannula therapy systems and to enhance the dose reaching the lower respiratory tract. These methods have been evaluated using continuous inhalation flow rather than realistic inhalation/exhalation breathing cycles. The goal of this study was to evaluate in vitro aerosol drug delivery using condensational growth techniques during high-flow nasal cannula therapy using realistic breathing profiles and incorporating intermittent aerosol delivery techniques. METHODS: A mixer-heater combined with a vibrating mesh nebulizer was used to generate a submicrometer aerosol using a formulation of 0.2% albuterol sulfate and 0.2% sodium chloride in water. Delivery efficiency of the aerosol for 1 min through a nasal cannula was considered using an intermittent delivery regime with aerosol being emitted for either the entire inhalation time (2 s) or half of the inhalation period (1 s) and compared with continuous delivery. The deposition of the aerosol was evaluated in the nasal delivery components (ventilator tubing and cannula) and an in vitro adult nose-mouth-throat (NMT) model using 3 realistic breathing profiles. RESULTS: Significant improvements in dose delivered to the exit of the NMT model (ex-NMT) were observed for both condensational growth methods using intermittent aerosol delivery compared with continuous delivery, and increasing the tidal volume was found useful. The combination of the largest tidal volume with the shortest intermittent delivery time resulted in the lowest respiration losses and the highest ex-NMT delivered dose. CONCLUSIONS: Intermittent aerosol delivery using realistic breathing profiles of submicrometer condensational growth aerosols was found to be efficient in delivering nasally administered drugs in an in vitro airway model.

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Pulsating aerosols for drug delivery to the sinuses in healthy volunteers

Cited by 61 publications

References 14 publications

Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation

Sinonasal persistence of Pseudomonas aeruginosa after lung transplantation

Prospective evaluation of aerosol delivery by a powered nasal nebulizer in the cadaver model

Intermittent Aerosol Delivery to the Lungs During High-Flow Nasal Cannula Therapy

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