Pulsatile venous waveform quality in Fontan circulation-clinical implications, venous assists options and the future

Koçyıldırım, Ergin; Dur, Onur; Soran, Özlem; Tüzün, Egemen; Miller, Matthew W.; Housler, Greggory; Wearden, Peter D.; Fossum, Theresa W.; Morell, Victor O.; Pekkan, Kerem

doi:10.5152/akd.2012.126

Cited by 6 publications

(7 citation statements)

References 24 publications

(23 reference statements)

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“…ii. Approaches for handling of venous coronary flow, which drains into the RA, were analyzed and classified into two groups depending on whether the main PA was Mean (SD): 22.4 (1.5) Nawa et al 12 Mean (SD): 10.6 (1.75) Szabo et al 13 No data Szabo et al 14 Mean (SD): 22.3 (5.2) Tanoue et al 15 Mean (SD): 16.8 (2.7) Ovine Gandolfo et al 16 Range: 42.0-48.0 Koçyıldırım et al 17 Mean (SD): 65.0 (4.1) Myers et al 18 Mean (SD): 7.2 (1.1) Riemer et al 19 Range: 42.0-48.0 Rodefeld et al 20 Mean: 56.5; range: 33.0-78.6 Rodefeld et al 21 Mean (SD): 5.6 (1.5) Swartz et al 22 Mean (SD): 56.6 (5.7) Tsuda et al 23 Range: 47.0-57.0 Wang et al 24 Range: 35.0-45.0 Wang et al 25 Range: 35.0-45.0 Wang et al 26 Range: 35.0-45.0 Porcine Derk et al 27 Mean:50.7; range 44.0-61.0 Kanakis et al 28 Mean (SD): 43.0 (3.8) Klautz et al 29 Mean (SD): 28.3 (7.9) Macé et al 30 Mean (SD): 31.4 (4.0) Sinha et al 31 Mean: 25.0 Wei et al 32 Mean (SD): 8.8 (0.9)…”

Section: Surgical Classificationmentioning

confidence: 99%

Approaches to Establish Extracardiac Total Cavopulmonary Connections in Animal Models—A Review

Granegger

Valencia

Quandt

et al. 2019

World J Pediatr Congenit Heart Surg

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BACKGROUND Long-term survival of patients with a single ventricle palliated with a Fontan procedure is still limited. No curative treatment options are available. To investigate the pathophysiology and potential treatment options, such as mechanical circulatory support (MCS), appropriate large animal models are required. The aim of this review was to analyze all full-text manuscripts presenting approaches for an extracardiac total cavopulmonary connection (TCPC) animal model to identify the feasibility and limitations in the acute and chronic setting. METHODS A literature search was performed for fulltext publications presenting large animal models with extracardiac TCPCs on Pubmed and Embase. Out of 454 reviewed papers, 23 manuscripts fulfilled the inclusion criteria. Surgical procedures were categorized and hemodynamic changes at the transition from the biventricular to the univentricular condition analyzed. RESULTS Surgical procedures varied especially regarding coronary venous flow handling and anatomic shape of the TCPC. In most studies (n = 14), the main pulmonary artery was clamped and the coronary venous flow redirected by additional surgical interventions. Only in five reports, the caval veins were connected to the right pulmonary artery to create a true TCPC shape, whereas in all others (n = 18), the veins were connected to the main pulmonary artery. An elevated pulmonary vascular resistance was identified as a limiting hemodynamic factor for TCPC completion in healthy animals. CONCLUSIONS A variety of acute TCPC animal models were successfully established with and without MCS, reflecting the most important hemodynamic features of a Fontan circulation; however, chronic animal models were not reported.

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Section: Surgical Classificationmentioning

confidence: 99%

Approaches to Establish Extracardiac Total Cavopulmonary Connections in Animal Models—A Review

Granegger

Valencia

Quandt

et al. 2019

World J Pediatr Congenit Heart Surg

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“…Published studies of this approach for Fontan patients are rare . Kocyildirim et al are the most recent group to have studied EECP for use in failing Fontan patients. Their study sought to identify the effect of the counter‐pulsatile flow in the TCPC in three Fontan patients.…”

Section: New Mcs Devices Under Developmentmentioning

confidence: 99%

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

et al. 2016

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The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations. Several devices that are specifically designed for patients with complex CHD are in the development pipeline undergoing rigorous animal testing as readiness experiments in preparation for future clinical trials. These advances in the development of new blood pumps for patients with CHD will address a significant unmet clinical need, as well as generally improve innovation of the current state of the art in MCS technology.

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“…Pharmacological and other therapies have variable success [11][12][13][14]. The probability of successful outcome with heart transplantation is low [15][16][17][18][19]. Some have suggested "assisting" the Fontan circulation using an implanted, intravascular, synthetic, externally powered pump [20][21][22][23].…”

Section: Post Fontan Paradox and Fenestrationmentioning

confidence: 99%

Laboratory Development of a Self-Powered FONTAN for Treatment of Congenital Heart Disease

Das

Khoury²,

Tibbets

et al. 2017

Proceeding of Second Thermal and Fluids Engineering Conference

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I cannot express enough gratitude to my thesis advisor Dr. Eduardo Divo for all of his complete support and advice which he provided throughout my research work. He not only guided me in completing my research work but also he showed me the path to shape my life in a better manner by helping me to choose the correct decisions at crucial times. I will be forever grateful to him. I would also like to thank my committee members Professor Jean M. Dhainaut, Professor Victor Huayamave and Dr. William Decampli for their insight and feedback during my research. My heartfelt thanks go to Kristin Sverrisdottir for her complete support throughout all these years. Without your friendship this journey of mine in abroad would not have been this awesome and pleasant. You always stood beside me. The time we spent together is invaluable to me. A special thanks to Rebecca Gold for editing my writing on such short notices. I really appreciate your hard work. I am also thankful to the whole senior design group of 2015-16 and Anthony Khoury and Jake Tibbets for their diligent work to make this research successful. I wish you all the best of luck through your endeavors. I am so grateful to my family, especially my parents and my late grandmother "Priti Kana das" for my upbringing and for being there for me during all my hard times. Last but not the least I would like to thanks all my friends especially Bhushan, Sultan and Alex to make my graduate school life awesome.

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Pulsatile venous waveform quality in Fontan circulation-clinical implications, venous assists options and the future

Cited by 6 publications

References 24 publications

Approaches to Establish Extracardiac Total Cavopulmonary Connections in Animal Models—A Review

Approaches to Establish Extracardiac Total Cavopulmonary Connections in Animal Models—A Review

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

Laboratory Development of a Self-Powered FONTAN for Treatment of Congenital Heart Disease

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