Pulsatile Drug Delivery System-a Technique of Delivering Drug in Accordance With Biological Clock - A Review

Abstract

Over last 30 years pulsatile drug delivery system has achieved a lot of importance in drug delivery technology. And the reason why this pulsatile drug delivery is gaining importance is because of its strategy of delivering drug molecule at right place, right time. There are certain diseases which are controlled by biological clock of our body and follow circadian rhythms like congestive heart failure, asthma, rheumatoid arthritis ,osteoarthritis, inflammatory disorders and other hormonal disorders, for this type of diseases conventional solid dosage forms like immediate release tablets or modified dosage forms like sustained, controlled release tablets cant give the required therapeutic response and also for such diseases delivering the drug at right time in right amount is very important. And that task is accomplished by this pulsatile drug delivery system. These pulsatile drug delivery framework is planned by the organic mood i.e., biological rhythms of the body, and medication conveyance is worked with by as per disease cadence. The rule for the utilization of pulsatile drug delivery of the medications is the place where a consistent drug discharge isnt wanted. The principle for the utilization of pulsatile release of the medications is the place where a steady drug discharge isnt wanted, yet drug release must be planned in such a way that, quick medication discharge is accomplished after the lag time. Current review examined the clarifications for improvement of pulsatile drug delivery framework in accordane with body circadian rhythm, kinds of the illness during which pulsatile discharge is required, order, assessments, benefits, impediments.

pH-dependent pulsatile delivery of Ambrisentan for the treatment of hypertension

“…A pulsatile drug delivery system (PDDS) is defined as the ''system which releases the drug rapidly and completely after a lag time, thus providing spatial and temporal delivery and increasing patient compliance'' [15]. PDDS is differentiated from conventional for offering improved bioavailability, reduced adverse effects and tolerability, no risk of dose dumping, improved stability, patient comfort and compliance and achieved a unique release pattern [16].…”