Pulpal status of human primary teeth with physiological root resorption

Monteiro, Joana; Day, Peter; Duggal, M. S.; Morgan, Claire R.; Rodd, Helen

doi:10.1111/j.1365-263x.2008.00963.x

Cited by 36 publications

(40 citation statements)

References 27 publications

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“…Similarly, previous study (13) comparing primary teeth with physiological root resorption and young permanent teeth, verified that histologically these dental groups are identical. It has been shown that primary teeth retain the potential for sensation, healing, and repair until reaching advanced stages of physiological root resorption (6). Such findings support the use of the pulp of third molar permanent teeth, with incomplete root formation, as a control group in this study.…”

Section: Discussionsupporting

confidence: 84%

“…Several studies have focused on the occurrence of necrosis in dental tissues, but very few have dealt with apoptosis and its role in physiological root resorption of primary teeth (4)(5)(6)(7)20).…”

Section: Discussionmentioning

confidence: 99%

“…During the physiological root resorption in primary teeth, the pulp is also eliminated. However, the sequence of events and the mechanism responsible for the physiological death of pulp cells remain unclear (4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

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Apoptosis in pulp elimination during physiological root resorption in human primary teeth

et al. 2009

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Pulp samples of 50 healthy human teeth with indication for extraction were examined to evaluate the role of apoptosis in pulp elimination during physiological root resorption. Two groups were formed: a test group (n=30) composed of pulp samples of primary teeth with physiological root resorption and a control group (n=20) composed of pulp samples of permanent maxillary third molars. Morphological evidence of apoptosis as well as in situ detection of cellular DNA fragmentation by TUNEL assay and detection of internucleosomal pattern of fragmentation of the genomic DNA by electrophoresis were observed. The apoptotic index of the primary tooth group was significantly higher than that of the permanent tooth group (51.01 ± 0.52 versus 25.32 ± 0.68) (p<0.001). TUNEL reaction showed intense and diffuse labeling in the pulp samples of primary teeth, which were discrete in the controls. Intense DNA internucleosomal fragmentation, a specific pattern for apoptosis, was observed in primary tooth pulps DNA by electrophoresis, in the permanent tooth pulps this pattern fragmentation of the genomic DNA for apoptosis were not present. These results seem to indicate a role of apoptosis in pulp elimination during the physiological root resorption of human primary teeth.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Apoptosis in pulp elimination during physiological root resorption in human primary teeth

et al. 2009

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“…The pulp is also eliminated by apoptosis during the process of physiological root resorption in primary teeth. However, the sequence of events and the definitive reason for the physiological death of pulp cells remain unclear (Monteiro et al, 2009).…”

Section: Other Cell Populationsmentioning

confidence: 99%

Apoptotic Signaling in Mouse Odontogenesis

Matalová

Švandová

Tucker

2012

OMICS: A Journal of Integrative Biology

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Apoptosis is an important morphogenetic event in embryogenesis as well as during postnatal life. In the last 2 decades, apoptosis in tooth development (odontogenesis) has been investigated with gradually increasing focus on the mechanisms and signaling pathways involved. The molecular machinery responsible for apoptosis exhibits a high degree of conservation but also organ and tissue specific patterns. This review aims to discuss recent knowledge about apoptotic signaling networks during odontogenesis, concentrating on the mouse, which is often used as a model organism for human dentistry. Apoptosis accompanies the entire development of the tooth and corresponding remodeling of the surrounding bony tissue. It is most evident in its role in the elimination of signaling centers within developing teeth, removal of vestigal tooth germs, and in odontoblast and ameloblast organization during tooth mineralization. Dental apoptosis is caspase dependent and proceeds via mitochondrial mediated cell death with possible amplification by Fas-FasL signaling modulated by Bcl-2 family members.

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“…Furthermore, there is increasing basic science research to support the potential of the primary tooth pulp for healing and repair, even though it is a 'temporary' structure destined for physiological root resorption and exfoliation. 2 Many myths about the pain processing potential and inflammatory responses of the primary tooth have now been dispelled and treatments should strive to be much more biologically compatible.…”

Section: Bda Conferencementioning

confidence: 99%

Caring for children: little teeth, big challenges

Rodd

2012

Br Dent J

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The need to restore the carious primary dentition remains an area of considerable controversy and debate. Huge disparity exists between how British general dental practitioners manage carious primary teeth compared to permanent teeth. 1 Indeed, recent data show that only around 10% of carious primary teeth are actually filled. In contrast, paediatric dentists strongly advocate a restorative approach, their casemix being largely comprised of children suffering from the sequelae of untreated caries. A multi-centre randomised controlled trial (the FiCTION trial) is currently underway to explore the effectiveness of a restorative versus a preventive strategy for the primary dentition, the findings of which should have great public health significance. Furthermore, there is increasing basic science research to support the potential of the primary tooth pulp for healing and repair, even though it is a 'temporary' structure destined for physiological root resorption and exfoliation. 2 Many myths about the pain processing potential and inflammatory responses of the primary tooth have now been dispelled and treatments should strive to be much more biologically compatible. A RESTORATIVE VERSUS PREVENTIVE APPROACHUndoubtedly, there are many challenges in providing restorative care for young children in primary care settings, not least time and financial constraints, as well as a perception that children may not cope well with treatment. A number of studies have explored the barriers to treating children in practice and have revealed some fascinating insights. 3 However, good decision-making, evidence-based restorative choices and a child-friendly approach will maximise successful clinical and patientreported outcomes.In my presentation at the forthcoming BDA conference, I will be highlighting the importance of decision-making for young children and will consider what patientrelated and clinical factors indicate a restorative approach. There are situations where even a specialist paediatric dentist would not get a hand-piece out! It should also be stressed that an individualised preventive strategy should always be in place, as this provides the foundation of any treatment plan. The range of restorative materials available for the primary dentition will be described, taking into account each of their advantages and limitations. The current literature will be reviewed for the best evidence-base practice and outcomes.It is interesting to reflect on how little amalgam is now used in the primary dentition; indeed it is actively discouraged in some countries. The advent of adhesive materials has largely contributed to the demise of amalgam as they offer a more cosmetic and, of course, a mercury-free alternative. However, glass ionomers in particular may lend themselves to abuse, and ultimately high failure rates, through poor clinical technique. PREFORMED METAL CROWNSAnother restorative choice for carious primary molars is the preformed metal crown (previously known as stainless steel crowns) (Fig. 1). This is further area where...

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Pulpal status of human primary teeth with physiological root resorption

Cited by 36 publications

References 27 publications

Apoptosis in pulp elimination during physiological root resorption in human primary teeth

Apoptosis in pulp elimination during physiological root resorption in human primary teeth

Apoptotic Signaling in Mouse Odontogenesis

Caring for children: little teeth, big challenges

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