Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain

Mladenović, Irena; Krunic, Jelena; Šupić, Gordana; Kozomara, Ružica; Bokonjić, Dejan; Stojanović, Nenad; Magić, Zvonko

doi:10.1016/j.joen.2018.02.002

Cited by 13 publications

(12 citation statements)

References 33 publications

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“…Beside gonadal hormones, many other factors can influence the perception of experimental stimuli during the menstrual cycle, including the presence of clinical pain. TMD, as chronic pain condition, may enhance sensitivity to noxious stimuli, 14,16,18 and decrease ability to modulate evoked acute orofacial pain 34 . This may be due to chronic hyperexcitability of primary trigeminal or central nociceptive fibres and an impaired pain regulatory system 14,34 .…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was calculated based on previous study, 18 after extracting data (mean and standard deviation) of pulp sensitivity to cold stimuli of female healthy subjects (2.95 ± 1.77) and TMD patients (4.77 ± 2.02). With consideration of type I error of 0.05 and a power of 0.80, the minimum estimated sample size was calculated to be 19 subjects per group.…”

Section: Methodsmentioning

confidence: 99%

“…Regarding experimental pain, women with TMD reported higher palpation pain intensity in menstrual (days 1‐3) and midluteal phases (7‐8 days after ovulation) 16 and lowest pressure pain thresholds in the perimenstrual phase (days 27‐1) 17 . Findings on dental pulp sensitivity in TMD patients indicate increased pulp response to cold, but not to electric stimuli in comparison with pain‐free subjects 18 . However, menstrual changes in pulp sensitivity in women diagnosed to have TMD have not been investigated so far.…”

Section: Introductionmentioning

confidence: 99%

“…17 Findings on dental pulp sensitivity in TMD patients indicate increased pulp response to cold, but not to electric stimuli in comparison with painfree subjects. 18 However, menstrual changes in pulp sensitivity in women diagnosed to have TMD have not been investigated so far.…”

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confidence: 99%

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Changes in pulp sensitivity across the menstrual cycle in healthy women and women with temporomandibular disorders

Krunic

Mladenović

Radović

et al. 2020

J of Oral Rehabilitation

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Background Menstrual cycle may contribute to experimental pain measures in healthy women and women with chronic pain. Objectives The present study aimed to investigate variation in pulp sensitivity across the menstrual cycle in healthy women and women with temporomandibular disorders (TMD) and to explore the effect of TMD pain and psychosocial variables on the pulp response. Methods This longitudinal study involved 47 regularly menstruating women aged 20‐45, 24 healthy and 23 with diagnosed painful TMD. The electric and cold stimuli were performed by electric pulp tester and refrigerant spray, respectively, on mandibular lateral incisors, in five menstrual phases (menstrual, follicular, periovulatory, luteal and premenstrual). Research Diagnostic Criteria for TMD were used to assess TMD, chronic pain, depression and somatisation. Regression analysis was performed to investigate the effect of the predictor variables on the pulp sensitivity. Results Significant phase‐related differences were observed for pain intensity to cold stimuli. Higher pain sensitivity was reported in menstrual in comparison with luteal phase (P = .019) among healthy women, and in menstrual in comparison with follicular (P = .033), periovulatory (P = .003) and luteal (P = .007) phases in TMD women. No significant differences were recorded for electric stimuli. Regression analysis identified depression as the determinant of cold and electric response in menstrual phase, regardless of age and presence of TMD. Conclusion Menstrual phase in healthy and TMD women with regular menstrual cycle is characterised with higher pulp sensitivity to cold stimuli. Depressive symptoms independently influence pulp response in this phase.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Changes in pulp sensitivity across the menstrual cycle in healthy women and women with temporomandibular disorders

Krunic

Mladenović

Radović

et al. 2020

J of Oral Rehabilitation

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“…Subsequent studies have provided further evidence that certain COMT genotypes may be significant risk or protective factors in the development of TMD. [32][33][34][35][36] However, research has also indicated that no single gene is responsible for TMD. A systematic review of family and genetic association studies in TMD concluded that TMD heritability is multifaceted, with the most evidence for contributions from genes encoding proteins involved in the serotonergic and catecholaminergic systems.…”

Section: Pre-diagnosismentioning

confidence: 99%

Biomarkers in temporomandibular disorder and trigeminal neuralgia: A conceptual framework for understanding chronic pain

Doshi

Nixdorf

Campbell

et al. 2020

Canadian Journal of Pain

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In this review, we will explore the use of biomarkers in chronic pain, using the examples of two prototypical facial pain conditions: trigeminal neuralgia and temporomandibular disorder. We will discuss the main categories of biomarkers and identify various genetic/genomic, molecular, neuroradiological, and psychophysical biomarkers in both facial pain conditions, using them to compare and contrast features of neuropathic, nonneuropathic, and mixed pain. By using two distinct model facial pain conditions to explore pain biomarkers, we aim to familiarize readers with different types of biomarkers currently being studied in chronic pain and explore how these biomarkers may be used to develop new precision medicine approaches to pain diagnosis, prognosis, and management. RÉSUMÉ Dans cette revue, nous examinerons l'utilisation de biomarqueurs dans la douleur chronique, en utilisant les exemples de deux affections prototypiques de douleur faciale : la névralgie du trijumeau et le trouble temporomandibulaire. Nous discuterons des principales catégories de biomarqueurs et identifierons divers biomarqueurs géétiques/génomiques, moléculaires, neuroradiologiques et psychophysiques pour ces deux pathologies, en les utilisant pour comparer et distinguer les caractéristiques de la douleur neuropathique, non neuropathique et mixte. En utilisant deux modèles distincts de douleur faciale pour explorer les biomarqueurs de la douleur, nous visons à familiariser les lecteurs avec différents types de biomarqueurs actuellement étudiés dans la douleur chronique et à examiner comment ces biomarqueurs peuvent être utilisés pour développer de nouvelles approches de médecine de précision pour le diagnostic, le pronostic et la prise en charge de la douleur.

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Sex, Race, and Genomics of Pain

Cong

Tan

Weidig

2020

Genomics of Pain and Co-Morbid Symptoms

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Pulp Sensitivity: Influence of Sex, Psychosocial Variables, COMT Gene, and Chronic Facial Pain

Cited by 13 publications

References 33 publications

Changes in pulp sensitivity across the menstrual cycle in healthy women and women with temporomandibular disorders

Changes in pulp sensitivity across the menstrual cycle in healthy women and women with temporomandibular disorders

Biomarkers in temporomandibular disorder and trigeminal neuralgia: A conceptual framework for understanding chronic pain

Sex, Race, and Genomics of Pain

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