Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review

Zanini, Marjorie; Meyer, Elisabeth; Simon, Stéphane

doi:10.1016/j.joen.2017.02.009

Cited by 119 publications

(140 citation statements)

References 97 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…However, there is still insufficient evidence to determine whether the presence, nature and duration of clinical symptoms gives accurate information about the extent of pulp inflammation, as pulpotomy was found to be an effective emergency treatment strategy with respect to relieving clinical symptoms, even in cases of irreversible pulpitis with symptomatic apical periodontitis. Advanced diagnostic strategies are needed to determine whether there is a correlation between clinical symptoms and actual pulpal inflammation (Zanini et al 2017). Oguntebi et al (1992) observed a greater incidence of postoperative pain (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Advanced diagnostic strategies are needed to determine whether there is a correlation between clinical symptoms and actual pulpal inflammation (Zanini et al 2017). However, there is still insufficient evidence to determine whether the presence, nature and duration of clinical symptoms gives accurate information about the extent of pulp inflammation, as pulpotomy was found to be an effective emergency treatment strategy with respect to relieving clinical symptoms, even in cases of irreversible pulpitis with symptomatic apical periodontitis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial

2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial

2017

View full text Add to dashboard Cite

show abstract

“…, Zanini et al . ); however, at present biomarkers are not specific enough to predictably dictate treatment (Zehnder et al . ).…”

Section: Reviewmentioning

confidence: 99%

“…A quantitative analysis (the actual number of inflamed cells, inflammatory markers) and a qualitative analysis have been described and correlated to caries depth, caries proximity to the pulp and the inflammatory state of the pulp (McLachlan et al 2003). Potentially discriminatory biomarkers have been identified, which could potentially set an inflammatory threshold above which the pulp is not viable (Rechenberg et al 2016, Zanini et al 2017; however, at present biomarkers are not specific enough to predictably dictate treatment (Zehnder et al 2011). Further clinical studies investigating molecularbased assays are required to develop reliable diagnostic tools and better reproducibility.…”

Section: Pulp Inflammation and In Situ Diagnosismentioning

confidence: 99%

Management of deep caries and the exposed pulp

et al. 2019

View full text Add to dashboard Cite

Caries prevalence remains high throughout the world, with the burden of disease increasingly affecting older and socially disadvantaged groups in Western cultures. If left untreated, caries will advance through dentine stimulating pulpitis and eventually pulp infection and necrosis; however, if conservatively managed, pulpal recovery occurs even in deep carious lesions. Traditionally, deep caries management was destructive with nonselective (complete) removal of all carious dentine; however, the promotion of minimally invasive biologically based treatment strategies has been advocated for selective (partial) caries removal and a reduced risk of pulp exposure. Selective caries removal strategies can be one‐visit as indirect pulp treatment or two‐visit using a stepwise approach. Management strategies for the treatment of the cariously exposed pulp are also shifting with avoidance of pulpectomy and the re‐emergence of vital pulp treatment (VPT) techniques such as partial and complete pulpotomy. These changes stem from an improved understanding of the pulp–dentine complex's defensive and reparative response to irritation, with harnessing the release of bioactive dentine matrix components and careful handling of the damaged tissue considered critical. Notably, the development of new pulp capping materials such as mineral trioxide aggregate, which although not an ideal material, has resulted in more predictable treatments from both a histological and a clinical perspective. Unfortunately, the changes in management are only supported by relatively weak evidence with case series, cohort studies and preliminary studies containing low patient numbers forming the bulk of the evidence. As a result, critical questions related to the superiority of one caries removal technique over another, the best pulp capping biomaterial or whether pulp exposure is a negative prognostic factor remain unanswered. There is an urgent need to promote minimally invasive treatment strategies in Operative Dentistry and Endodontology; however, the development of accurate diagnostic tools, evidence‐based management strategies and education in management of the exposed pulp are critical in the future.

show abstract

“…Of the many inflammatory mediators, IL‐8 has been extensively studied as a potential marker for irreversible pulpitis . Increased expression of IL‐8 is correlated with increased polymorphonuclear neutrophils (PMNs) within the pulp because IL‐8 induces neutrophil chemotaxis and release of degradation enzymes during degranulation . The role played by neuropeptides such as substance P has gained much attention in recent times .…”

Section: Introductionmentioning

confidence: 99%

Influence of different irrigants on substance P and IL‐8 expression for single visit root canal treatment in acute irreversible pulpitis

J¹,

Sherwood²,

Abbott

et al. 2019

Aust Endodontic J

View full text Add to dashboard Cite

The aim of this study was to assess the influence of ketorolac tromethamine and dexamethasone on substance P and IL-8 expression when used as a root canal irrigant for single visit root canal treatment for acute irreversible pulpitis. A total of 42 patients with pain due to acute irreversible pulpitis in carious premolar and molar teeth were included in this study. The four irrigation groups were as follows: saline (n = 11), 3% sodium hypochlorite (n = 11), ketorolac tromethamine (n = 10) and dexamethasone (n = 10). Blood samples S1 and S2 were collected upon access opening and after canal preparation, respectively. Quantification of substance P and IL-8 were done using ELISA test. Post-operative pain was assessed by questioning the patients. The difference between S1 and S2 sample values for the four different irrigant groups was not significant. The sodium hypochlorite group had a higher mean expression of substance P and IL-8 values. Dexamethasone irrigation was more effective in controlling post-operative pain.

show abstract

Pulp Inflammation Diagnosis from Clinical to Inflammatory Mediators: A Systematic Review

Cited by 119 publications

References 97 publications

Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial

Assessment of alternative emergency treatments for symptomatic irreversible pulpitis: a randomized clinical trial

Management of deep caries and the exposed pulp

Influence of different irrigants on substance P and IL‐8 expression for single visit root canal treatment in acute irreversible pulpitis

Contact Info

Product

Resources

About