Pulp Anatomy and Characterization of Pulp Cells

Goldberg, Michel

doi:10.1007/978-3-642-55160-4_2

Cited by 8 publications

(16 citation statements)

References 46 publications

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“…One interesting hypothesis is that the sub-odontoblastic cells take part in replenishment of the odontoblast layer. If so, they could be activated to become terminally differentiated if needed (Goldberg, 2014). This hypothesis is supported by the fact that the subodontoblastic cells express high alkaline phosphatase (ALP) activity.…”

Section: Odontoblastsmentioning

confidence: 99%

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors

Dyachuk

Furlan

Shahidi

et al. 2014

Science

194

180

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The peripheral autonomic nervous system reaches far throughout the body and includes neurons of diverse functions, such as sympathetic and parasympathetic. We show that the parasympathetic system in mice--including trunk ganglia and the cranial ciliary, pterygopalatine, lingual, submandibular, and otic ganglia--arise from glial cells in nerves, not neural crest cells. The parasympathetic fate is induced in nerve-associated Schwann cell precursors at distal peripheral sites. We used multicolor Cre-reporter lineage tracing to show that most of these neurons arise from bi-potent progenitors that generate both glia and neurons. This nerve origin places cellular elements for generating parasympathetic neurons in diverse tissues and organs, which may enable wiring of the developing parasympathetic nervous system.

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Section: Odontoblastsmentioning

confidence: 99%

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors

Dyachuk

Furlan

Shahidi

et al. 2014

Science

194

180

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show abstract

“…For many years, Root Canal Treatments (RCT) used traditional protocols imposing the careful cleaning of the canals, the removal of the smear layer, and the sealing of the filling materials inside the pulp chamber [1,2]. These procedures were combined with the manual, instrumental or chemical shaping of the root lumen [3].…”

Section: Why How and When Traditional Root Canal Treatments (Rct) Armentioning

confidence: 99%

Root Canal Treatment (RCT): From Traditional Endodontic Therapies to Innovating Pulp Regeneration

Goldberg¹

2016

JDODT

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Traditional protocols involve the cleaning of the pulp chamber and root canals, the removal of bacteria and of the smear layer, and ultimately to the sealing of endodontic materials filling the pulp, and root lumen. Disinfection combined with mechanical enlargement allows occluding the lumen of the dental pulp with a central master cone, and lateral condensation using a series of small accessory cones. Innovative approaches propose bioengineered scaffolds, growth and transcription factors. Removal of the smear layer reveals different types of globular and non-globular dentins (osteodentin, osteodentin, fibrodentin), cleaning the dentinal walls before chemical or mechanical enlargement of the lumen. Three distinct options open gates for classical endodontic therapies before conventional filling. New pulp therapies derived from apexogenesis and apexification contributes to the formation of a renewed dental pulp, involving totipotent, multipotent and unipotent stem cell. Proliferation of structural cells, signaling factors, transcription factors, metalloproteinases, and cytokines are involved in pulp renewal. Coronal and root microvascularization participate to pulp regeneration and ultimately to pulp mineralization. BMP-2, TGF-β1, MTA and Portland cement may also contribute to the requirements for pulp bioengineering, leading to the future of innovating biological pulp therapies. Dental caries are mostly due to bacteria and subsequently to pulp infection [3]. Associated to the dental plaque; microorganisms alter enamel surface, either beneath the proximal contacts areas, or in the face-to-face enamelling occlusal fissures. The initial carious lesions is formed at this precocious stage. The carious lesion crosses the whole enamel thickness and spread laterally along the enlarged dentino-enamel junction. The lesion degrades firstly the mantle dentin. Caries penetrate the subjacent circumpulpal dentin through dentinal tubules

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“…The carious decay contributes to the occlusion of the tubules by intratubular mineralizations (whitlockite crystallites, tricalcium phosphate) (Goldberg 2014 In the cervical zone, prisms ( P ) are aligned and parallel. These tubules are straight, aligned, and at right angles to the tooth surface.…”

Section: Dentinmentioning

confidence: 99%

Understanding Dental Caries

Goldberg¹

2016

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Pulp Anatomy and Characterization of Pulp Cells

Cited by 8 publications

References 46 publications

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors

Parasympathetic neurons originate from nerve-associated peripheral glial progenitors

Root Canal Treatment (RCT): From Traditional Endodontic Therapies to Innovating Pulp Regeneration

Understanding Dental Caries

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