Pulmonary α-1,3-Glucan–Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy

Patel, Parit A.; King, R. Glenn; Kearney, John F.

doi:10.4049/jimmunol.1601039

Cited by 17 publications

(11 citation statements)

References 56 publications

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“…Using mouse models in which innate immune receptors have been genetically deleted has provided information about how allergic disease is initiated; however, this information has not yet lead to viable therapeutics for treating or preventing asthma. We suggest instead that pulmonary antibodies targeting these conserved antigen-linked glycans such as β-1,3-glucan or GlcNAc, or those targeting PAMPs such as Bartonella-derived LPS in the case of HDM may more effectively neutralize allergenic particles in the lung (22, 61, 62). Levels of these, and other, antibodies in the lungs of children may also be predictive for asthma development.…”

Section: Discussionmentioning

confidence: 99%

CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development

Patel

Kearney

2017

The Journal of Immunology

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Over 89% of asthmatic children in underdeveloped countries demonstrate sensitivity to house dust mites (HDM). The allergic response to HDM is partially mediated by epithelial cell-derived cytokines that activate group-2 innate lymphoid cells (ILC2s), induce migration and activation of dendritic cells (DCs), and promote effector differentiation of HDM-specific TH2 cells. However, the contribution of innate receptor engagement on epithelial or dendritic cells by HDM that ultimately mediates said innate and adaptive allergic responses is poorly understood. We and others have demonstrated that HDM express phosphorylcholine (PC) moieties. The major PC receptors involved in immune responses include CD36 and platelet activating factor receptor (PAFR). Because both CD36 and PAFR are expressed by epithelial cells and DCs, and expression of these receptors is higher in human asthmatics, we determined whether engagement of CD36 or PAFR on epithelial or dendritic cells contributes to HDM allergy development. Testing bone marrow chimeric mice revealed that CD36 engagement on radioresistant cells and PAFR engagement on both radioresistant and radiosensitive cells in the lung promote allergic responses to HDM. Additionally, passive anti-PC IgM antibodies administered intratracheally with HDM decreased allergen uptake by epithelial and APCs in the lungs of C57BL/6 mice, but not CD36−/− or PAFR−/− mice. These results show that CD36 and PAFR are important mediators of HDM allergy development, and inhibiting HDM engagement with PC receptors in the lung protects against allergic airway disease.

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Section: Discussionmentioning

confidence: 99%

CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development

Patel

Kearney

2017

The Journal of Immunology

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“…Second, activation of the signaling associated with the aryl hydrocarbon receptor (which responds to environmental stimuli and is involved in the pathogenesis of asthma), protected lungs from cockroach-induced inflammation [48]. Third, neonatal mice immunized with α-1,3 glucan developed IgA-secreting B cells that suppressed the development of cockroach allergy [49]. Most of these studies were performed with cockroach extracts that are known to be very variable in content [50].…”

Section: Mechanisms Leading To Cockroach Allergymentioning

confidence: 99%

New Insights into Cockroach Allergens

Pomés

Mueller

Randall

et al. 2017

Curr Allergy Asthma Rep

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Purpose of review This review addresses the most recent developments on cockroach allergen research in relation to allergic diseases, especially asthma. Recent findings The number of allergens relevant to cockroach allergy has recently expanded considerably up to 12 groups. New X-ray crystal structures of allergens from groups 1, 2 and 5 revealed interesting features with implications for allergen standardization, sensitization, diagnosis and therapy. Summary Cockroach allergy is strongly associated with asthma particularly among children and young adults living in inner-city environments, posing challenges for disease control. Environmental interventions targeted at reducing cockroach allergen exposure have provided conflicting results. Immunotherapy may be a way to modify the natural history of cockroach allergy and decrease symptoms and asthma severity among sensitized and exposed individuals. The new information on cockroach allergens is important for the assessment of allergen markers of exposure and disease, and for the design of immunotherapy trials.

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“…In a recent study, production of α‐1,3‐glucan‐specific IgA in neonatal mice prevented the development of cockroach allergy , a feature potentially relevant to severe asthma . HDM‐specific IgA 2 was also associated with protection against eczema in allergic patients , while low levels of casein‐specific IgA were found in children with food protein‐induced allergic enterocolitis .…”

Section: Immunoglobulin a As Frontline Mucosal Antibodiesmentioning

confidence: 97%

The epithelial barrier and immunoglobulin A system in allergy

Carlier

Sibille

Pilette

2016

Clin Experimental Allergy

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Airway and intestinal epithelial layers represent first-line physical barriers, playing a key role in mucosal immunity. Barrier dysfunction, characterized by alterations such as disruption of cell-cell apical junctions and aberrant epithelial responses, probably constitutes early and key events for chronic immune responses to environmental antigens in the skin and in the gut. For instance, barrier dysfunction drives Th2 responses in atopic disorders or eosinophilic esophagitis. Such epithelial impairment is also a salient feature of allergic asthma and growing evidence indicates that barrier alterations probably play a driving role in this disease. IgA has been identified as the most abundant immunoglobulin in mucosa, where it acts as an active barrier through immune exclusion of inhaled or ingested antigens or pathogens. Historically, it has been thought to represent the serum factor underlying reaginic activity before IgE was discovered. Despite several studies about regulation and major functions of IgA at mucosal surfaces, its role in allergy remains largely unclear. This review aims at summarizing findings about epithelial functions and IgA biology that are relevant to allergy, and to integrate the emerging concepts and the recent developments in mucosal immunology, and how these could translate to clinical observations in allergy.

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Pulmonary α-1,3-Glucan–Specific IgA-Secreting B Cells Suppress the Development of Cockroach Allergy

Cited by 17 publications

References 56 publications

CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development

CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development

New Insights into Cockroach Allergens

The epithelial barrier and immunoglobulin A system in allergy

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