Pulmonary Vein Isolation Using a Second‐Generation Cryoballoon Catheter: A Randomized Comparison of Ablation Duration and Method of Deflation

Abstract

A single application with the second-generation cryoballoon catheter results in a high rate of PV isolation. The degree of vascular injury was not increased by active balloon deflation and no differences in acute efficacy or mature transmural circumferential lesions were observed with 2- versus 4-minute applications.

Reduced incidence of esophageal lesions by luminal esophageal temperature–guided second-generation cryoballoon ablation

“…In a canine model of CB2-PVI, the mean lesion depth was not different when comparing 2-minute with 4-minute ablation time. 18 In our study, EFI was performed in 3 patients (4%) within 2 minutes of freezing.…”

Acute procedural and cryoballoon characteristics from cryoablation of atrial fibrillation using the first- and second-generation cryoballoon: a retrospective comparative study with follow-up outcomes

“…Yet, concerns have been raised regarding the possibility of a higher complication rate including phrenic nerve (PN) palsy [8], esophageal ulceration [9,10], and even atrioesophageal fistulas [11]. As a result, some operators have resorted to shorter ablation times and tapered cryoapplications [12][13][14]. But there is limited data reported on the comparison between CB-1 and CB-2 with respect to efficacy and safety [15].…”

Novel Electromyographic Monitoring Technique for Prevention of Right Phrenic Nerve Palsy During Cryoballoon Ablation

“…Although the safety of this method has not been demonstrated in a large patient cohort, it is noteworthy that no complications were observed in small clinical series and animal studies. 9,10 Whether combining CMAP monitoring and forced deflation is necessary to avoid PNP is unclear and will require dedicated study.…”