Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature

Rahm, Ann‐Kathrin; Lugenbiel, Patrick; Ochs, Marco; Meder, Benjamin; Thomas, Dierk; Katus, Hugo A.; Scholz, Eberhard P.

doi:10.1007/s00392-020-01616-x

Cited by 2 publications

(3 citation statements)

References 31 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[89][90][91][92][93] Additionally, SNPs associated with electrical remodeling in lone AF have also been associated with AF recurrence post ablation, 94 and there is some emerging data concerning the effects of atrial cardiomyopathy 95 and DCM related variants on post-ablation outcomes. 96 By far, SNPs at locus 4q25 have consistently been associated with AF susceptibility, and there are a number of analyses indicating this locus' role in response to AF therapy. The SNP rs2200733, which was one of the first SNPs associated with increased AF susceptibility at 4q25 has been demonstrated to lead to decreased likelihood of arrhythmia-free survival and increased likelihood of AAD therapy post catheter ablation, possibly due to altered left atrial conduction patterns.…”

Section: Clinical Management Considerationsmentioning

confidence: 99%

Genetically Based Atrial Fibrillation: Current Considerations for Diagnosis and Management

Pensa

Baman

Puckelwartz

et al. 2022

Preprint

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common atrial arrhythmia and is subcategorized into numerous clinical phenotypes. Given its heterogeneity, investigations into the genetic mechanisms underlying AF have been pursued in recent decades, with predominant analyses focusing on early onset or lone AF. Linkage analyses, genome wide association studies (GWAS), and single gene analyses have led to the identification of rare and common genetic variants associated with AF risk. Significant overlap with genetic variants implicated in dilated cardiomyopathy syndromes, including truncating variants of the sarcomere protein titin, have been identified through these analyses, in addition to other genes associated with cardiac structure and function. Despite this, widespread utilization of genetic testing in AF remains hindered by the unclear impact of genetic risk identification on clinical outcomes and the high prevalence of variants of unknown significance (VUS). However, genetic testing is a reasonable option for patients with early onset AF and in those with significant family history of arrhythmia. While many knowledge gaps remain, emerging data support genotyping to inform selection of AF therapeutics. In this review we highlight the current understanding of the complex genetic basis of AF and explore the overlap of AF with inherited cardiomyopathy syndromes. We propose a set of criteria for clinical genetic testing in AF patients and outline future steps for the integration of genetics into AF care.

show abstract

Section: Clinical Management Considerationsmentioning

confidence: 99%

Genetically Based Atrial Fibrillation: Current Considerations for Diagnosis and Management

Pensa

Baman

Puckelwartz

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…A variety of SNPs associated with AF susceptibility have been shown to be associated with modulation of response to catheter ablation 85–89 . Additionally, SNPs associated with electrical remodeling in lone AF have also been associated with AF recurrence postablation, 100 and there is some emerging data concerning the effects of atrial cardiomyopathy 101 and DCM‐related variants on postablation outcomes 102 . By far, SNPs at locus 4q25 have consistently been associated with AF susceptibility, and there are a number of analyses indicating this locus' role in response to AF therapy.…”

Section: Clinical Management Considerationsmentioning

confidence: 99%

“…[85][86][87][88][89] Additionally, SNPs associated with electrical remodeling in lone AF have also been associated with AF recurrence postablation, 100 and there is some emerging data concerning the effects of atrial cardiomyopathy 101 and DCM-related variants on postablation outcomes. 102 By far, SNPs at locus 4q25 have consistently been associated with AF susceptibility, and there are a number of analyses indicating this locus' role in response to AF therapy. The SNP rs2200733, which was one of the first SNPs associated with increased AF susceptibility at 4q25, has been demonstrated to lead to decreased likelihood of arrhythmiafree survival and increased likelihood of AAD therapy postcatheter ablation, possibly due to altered LA conduction patterns.…”

Section: Clinical Management Considerationsmentioning

confidence: 99%

Genetically based atrial fibrillation: Current considerations for diagnosis and management

Pensa

Baman

Puckelwartz

et al. 2022

Cardiovasc electrophysiol

View full text Add to dashboard Cite

Atrial fibrillation (AF) is the most common atrial arrhythmia and is subcategorized into numerous clinical phenotypes. Given its heterogeneity, investigations into the genetic mechanisms underlying AF have been pursued in recent decades, with predominant analyses focusing on early onset or lone AF. Linkage analyses, genomewide association studies (GWAS), and single gene analyses have led to the identification of rare and common genetic variants associated with AF risk.Significant overlap with genetic variants implicated in dilated cardiomyopathy syndromes, including truncating variants of the sarcomere protein titin, have been identified through these analyses, in addition to other genes associated with cardiac structure and function. Despite this, widespread utilization of genetic testing in AF remains hindered by the unclear impact of genetic risk identification on clinical outcomes and the high prevalence of variants of unknown significance (VUS).However, genetic testing is a reasonable option for patients with early onset AF and in those with significant family history of arrhythmia. While many knowledge gaps remain, emerging data support genotyping to inform selection of AF therapeutics. In this review, we highlight the current understanding of the complex genetic basis of AF and explore the overlap of AF with inherited cardiomyopathy syndromes. We propose a set of criteria for clinical genetic testing in AF patients and outline future steps for the integration of genetics into AF care.

show abstract

Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature

Abstract: Graphic abstract

Cited by 2 publications

References 31 publications

Genetically Based Atrial Fibrillation: Current Considerations for Diagnosis and Management

Genetically Based Atrial Fibrillation: Current Considerations for Diagnosis and Management

Genetically based atrial fibrillation: Current considerations for diagnosis and management

Contact Info

Product

Resources

About