Pulmonary Vascular Resistance, but Not Diastolic Pulmonary Gradient, May Predict Survival in Pulmonary Hypertension: Insights From Euphrates Study

Dart to the target: an alternative bull’s eye parametric display for European Society of Cardiology / European Respiratory Society goal‐orientated risk reduction strategy in pulmonary arterial hypertension

“…In our EUPHRATES study comprising 481 patients with pulmonary hypertension (PH), baseline functional class (FC), PVR, and history of clinical worsening episode (CWE) after initial assessment, but not other baseline clinical and biochemical and treatment characteristics, diastolic pulmonary gradient, or other HD measures, were found to predict survival. 33 …”

“…31 In our EUPHRATES study comprising 481 patients with pulmonary hypertension (PH), baseline functional class (FC), PVR, and history of clinical worsening episode (CWE) after initial assessment, but not other baseline clinical and biochemical and treatment characteristics, diastolic pulmonary gradient, or other HD measures, were found to predict survival. 33 In another study investigating the prognostic impact of changes in HD, functional and biochemical variables after initiation of TT, changes in FC, CI, mixed venous oxygen saturation (SvO2), and N-terminal pro-brain natriuretic peptide (NT-proBNP) at first evaluation compared with baseline measures were proved to be independent predictors of subsequent outcome. 34 According to the change and satisfaction status in each variable at first evaluation, four clinical conditions were defined: group 1 ¼ persistently satisfactory; group 2 ¼ improved; group 3 ¼ deteriorated; and group 4 ¼ persistently unsatisfactory.…”