Pulmonary tumor embolism.

Bassiri, A; Haghighi, Babak; Doyle, Ramona L.; Berry, G J; Rizk, Norman W.

doi:10.1164/ajrccm.155.6.9196119

Cited by 84 publications

(75 citation statements)

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“…29 However, in their study the number of the patients according to the type of cancer was unknown, so the incidence of PE was not described. In most studies the described tumor PE has been limited to microscopic pulmonary tumor embolism, so we can not compare our data with those previously reported.…”

Section: Tumor Embolismmentioning

confidence: 98%

Cancer and Pulmonary Embolism Thrombotic Embolism, Tumor Embolism, and Tumor Invasion Into a Large Vein

Sakuma

Fukui

Nakamura

et al. 2006

Circ J

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ancer is a major risk factors for thrombotic pulmonary embolism (PE), [1][2][3][4] and thrombotic PE associated with cancer is known as Trousseau's syndrome. Cancer induces not only thrombotic PE but also tumor PE and tumor invasion into large veins. However, there is lack of epidemiological data from the general population to compare the incidence of thrombotic PE, tumor PE and tumor invasion to large veins according to the histopathology and the site of the cancer. Clinicians have given more attention to the prevention of venous thromboembolism (VTE) with chemotherapeutic and surgical treatment of cancer patients, but it is important to evaluate the risk of the development of VTE according to the histopathology and primary site of the cancer.The goal of this study was to investigate variations in the incidence of thrombotic PE, tumor PE and tumor invasion into large veins according to tumor histopathology and tumor site. MethodsA total of 65,181 cancer patients (66.0%) were identified from 98,736 postmortem examinations. [5][6][7] The incidence of PE, as well as the tumor site and the histopathology, was recorded for each case. PE was defined as critical (critical PE) when it was the primary cause of death or main diagnosis, and "total PE" was used to indicate the total number of thrombotic PEs, tumor PEs, bacterial PEs, mycotic PEs and other emboli (eg, fat, amniotic fluid etc). The type of emboli was determined by the pathologist performing the autopsy. Cases with 2 different types of emboli were counted twice. All cases were also reviewed for the presence of tumor invasion into a large vein. Within each PE group, the incidence of PE was compared between specific tumor types (adenocarcinoma, mucinous carcinoma, transi- Takeshi Nakano, MD*; Kunio Shirato, MDBackground The specific incidence of thrombotic pulmonary embolism (PE), tumor PE and tumor invasion into large veins according to tumor type and tumor site remains unclear. Methods and Results A total of 65,181 cancer patients were identified from 98,736 postmortem examinations. Thrombotic PE occurred in 2.32% of all cancer patients and comprised 88.6% of the total number of all PE events. The incidence of thrombotic PE was high in those with adenocarcinoma, leukemia and large cell carcinoma, and was low in those with hepatic cell carcinoma. The incidence of PE was high when tumor was present in hematogenous tissue, lungs, ovaries, pancreas and the biliary system, and was low when tumor was present in the liver. The incidence of tumor PE was high with large cell carcinoma, hepatic cell carcinoma and adenocarcinoma, and was also high when tumor was present in the lungs, ovaries, kidneys and liver. There was a significant correlation between the incidence of tumor PE and the incidence of tumor invasion into large veins. Conclusion The incidence of thrombotic PE, tumor PE and tumor invasion into large veins varies significantly according to tumor histopathology and tumor site. (Circ J 2006; 70: 744 -749)

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Section: Tumor Embolismmentioning

confidence: 98%

Cancer and Pulmonary Embolism Thrombotic Embolism, Tumor Embolism, and Tumor Invasion Into a Large Vein

Sakuma

Fukui

Nakamura

et al. 2006

Circ J

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“…Steroid treatment was administered for possible irradiation pneumonia, but was ineffective. Thyroid cancer has been recognized as one of the diseases commonly associated with pulmonary tumor embolism (20)(21)(22). Luo et al reported pulmonary tumor embolism in a patient with right ventricular metastasis of thyroid cancer based on the facts that the patient had no deep venous thrombosis and was on anticoagulant therapy (23).…”

Section: Discussionmentioning

confidence: 99%

Cardiac metastasis of squamous cell carcinoma of the thyroid gland with severe disseminated intravascular coagulation: A case report

Yoshihiro

Tsuchihashi

Kusaba

et al. 2016

Molecular and Clinical Oncology

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Abstract. Distant metastasis of primary squamous cell carcinoma (SCC) of the thyroid gland is rare and, to the best of our knowledge, cardiac metastasis has not been reported to date. A 57-year-old man underwent surgery and adjuvant chemoradiotherapy for stage IVA SCC of the thyroid gland. After 3 months, the patient was admitted to the Kyushu University Hospital (Fukuoka, Japan) with subcutaneous hematomas of the left thigh and lower leg, and he was diagnosed with cardiac and mediastinal lymph node metastases of SCC of the thyroid gland with severe disseminated intravascular coagulation (DIC). Echocardiography revealed a mass, 52 mm in greatest diameter, protruding from the interventricular septum towards the right ventricle. Weekly administration of paclitaxel and concurrent irradiation of the cardiac and lymph node metastases were performed. Eighteen days after the initiation of chemoradiotherapy, the DIC and hematomas had significantly improved, and the cardiac metastasis was stable. However, 2 months after admission, the patient developed dyspnea and multiple nodular shadows appeared to be spreading in the subpleura of the lungs bilaterally, which were initially suspected to be pulmonary tumor embolisms. Prednisolone and subsequent administration of lenvatinib were not effective and the patient succumbed to respiratory failure. Severe DIC caused by extremely rare cardiac metastasis of SCC of the thyroid gland was effectively controlled by chemoradiotherapy. However, intensive local control appears to be required for this condition.

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“…종양색전증은 전이병변을 가진 암환자에서 혈관계의 종양 세포들로 정의할 수 있는데 1) , 그 발생률은 여러 연구들에서 차이가 나지만, 대략 3-26% 정도로 알려져 있다 2) . Sorensen Fig.…”

Section: 서 론unclassified

A Case of Thyroid Papillary Carcinoma With Pulmonary Tumor Embolism

Lee

Kwak

Kim

et al. 2013

J Korean Geriatr Soc

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The tumor embolism is defined as tumor cells within the vascular system such as pulmonary artery that is not contiguous with the other metastatic foci. The incidence of tumor embolism varies widely ranging from 3% to 26% among seve ral studies; whereas lung cancer, prostate cancer, colorectal cancer, breast cancer, pancreas cancer are associated with high risks for tumor embolism. However thyroid cancer is rarely associated with tumor embolism. Among the rare cases, tumor embolism was reported as being mostly of follicular carcinoma or undifferentiated carcinoma, but few of papillary carcinoma. We report an unusual presentation that pulmonary tumor embolism from thyroid papillary carcinoma was diagnosed with positron emission tomography/computed tomography (CT) and chest CT.

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Pulmonary tumor embolism.

Cited by 84 publications

References 0 publications

Cancer and Pulmonary Embolism Thrombotic Embolism, Tumor Embolism, and Tumor Invasion Into a Large Vein

Cancer and Pulmonary Embolism Thrombotic Embolism, Tumor Embolism, and Tumor Invasion Into a Large Vein

Cardiac metastasis of squamous cell carcinoma of the thyroid gland with severe disseminated intravascular coagulation: A case report

A Case of Thyroid Papillary Carcinoma With Pulmonary Tumor Embolism

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