Pulmonary tuberculosis with acute respiratory failure: yet to be conquered

Aggarwal, Deepak; Mohapatra, P. R.

doi:10.1183/09031936.00117308

Cited by 1 publication

(2 citation statements)

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“…From previous studies, the incidence of active pulmonary tuberculosis complicated by acute respiratory failure was approximately 1.5% to 5% and the mortality rate was significantly high in a range of 30% to 100% (4,8,10,12). Our study also demonstrated the incidence of acute respiratory failure in 50% of hospitalized patients with pulmonary tuberculosis, which resulted in a mortality rate of around 54%.…”

Section: Discussionmentioning

confidence: 99%

“…From previous studies, acute respiratory failure was also indicated as a mortality risk in pulmonary tuberculosis. Although the incidence of acute respiratory failure induced by pulmonary tuberculosis from a previous observational study was approximately 1.5%, mortality of the patients with pulmonary tuberculosis who developed acute respiratory failure and required mechanical ventilation ranged between 47% and 80% (4,5,(7)(8)(9)(10)(11)(12). The mortality rate of active pulmonary tuberculosis requiring mechanical ventilation (TBMV) was double the mortality rate of patients with severe bacterial pneumonia who developed acute respiratory failure (13).…”

Section: Introductionmentioning

confidence: 99%

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Factors influencing development and mortality of acute respiratory failure in hospitalized patient with active pulmonary tuberculosis: a 10-year retrospective review

Bhurayanontachai¹,

Maneenil²

2016

J. Thorac. Dis.

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Background: Pulmonary tuberculosis with acute respiratory failure is fatal and is a burden in the intensive care units and leads to mortality. This retrospective study identifies the factors influencing the development of pulmonary tuberculosis requiring mechanical ventilation (TBMV) and mortality in the hospitalized patients with pulmonary tuberculosis. Methods:The medical records of hospitalized adult patients with pulmonary tuberculosis were retrospectively reviewed. Demographic data, clinical presentations, radiographic findings, biochemical tests, and clinical outcomes were collected. Data were compared by Student's t-test and Chi-square test between groups. Select variables that were statistically significant with P values <0.1 were introduced into a forward, stepwise, logistic regression model. Odds ratios (ORs) and their 95% confidence intervals (CIs) identified the independent influencing factors in the development of TBMV and mortality.Results: Of 268 enrolled patients, 185 (69.0%) were male. The patients were equally divided between the TBMV and non-TBMV groups. The shorter duration of illness (OR, 0.99; 95% CI, 0.98-0.99), underlying disease of AIDS (OR, 14.55; 95% CI, 1.71-123.91), presentation of fever (OR, 2.11; 95% CI, 1.20-3.71) and dyspnea (OR, 3.51; 95% CI, 2.02-6.11), large amount of acid fast bacilli on sputum smear (OR, 3.76; 95% CI, 1.90-7.47), lower serum albumin level (OR, 0.39; 95% CI, 0.26-0.59), and delayed initiation of antituberculosis agents (OR, 1.06; 95% CI, 1.00-1.12) were independent factors to develop TBMV. Male gender (OR, 2.16; 95% CI, 1.01-4.61), consolidation pattern on chest X-ray (OR, 2.41; 95% CI, 1.17-4.98), and lower serum albumin (OR, 0.39; 95% CI, 0.21-0.71) were correlated to mortality. Conclusions:The incidence and mortality rate of TBMV patients were high. Acute tuberculous pneumonia, underlying disease of AIDS, amount of acid fast bacilli, and delayed administration of antituberculosis agents were independent risk factors to develop TBMV. Male gender, consolidation on chest X-ray, and low serum albumin were significantly related to mortality.

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Section: Discussionmentioning

confidence: 99%