Pulmonary tuberculosis induces a systemic hypercoagulable state

Increased intra- and extracellular granzyme expression in patients with tuberculosis

“…For this we measured IL-6, CXCL8 and IP-10 (which are relevant in active TB) as well as sIL-2Ra, sTNFR-1, sTNFR-2 and CRP (which correlate with the extent of disease in TB [25]) in plasma of TB patients and healthy controls. As expected [25] and reported previously by our group [23], the plasma levels of all biomarkers were elevated in patients versus controls (all P < 0.0001; Supplementary Table 1). Levels of IFN-g, IL-12 and TNF-a remained below the limit of detection in most individuals (data not shown).…”

“…This survey was conducted as an additional study of a previous investigation evaluating activation of the coagulation system in patients with pulmonary TB, of which the results have been published [23]. The current study included 61 adult patients with pulmonary TB recruited prospectively in the Tuberculosis Clinic of Chittagong General Hospital and the Chittagong Medical College & Hospital, Chittagong, Bangladesh.…”

Estimation and Assessment of D-Dimer Levels in Sudanese Patients with Pulmonary Tuberculosis

“…The present study found an association between inflammation and hemostatic changes that can result in an acute phase response and a hypercoagulable state. This finding is in agreement with the study done in 2015 by Kager LM et al [18].…”

“…The fourth study is similar with our findings that reported by Turkey authors Güliz Ataç et al [17]. The sixth study was done in Bangladesh (2015) by Kager LM et al who concluded that there is a significant higher in D-dimer in patient than normal con- [18]. Our finding in the same line with the studies mentioned above .Based on the gender the current study showed that there is no statistically significant difference between the patients male and female with pulmonary tuberculosis and D-dimer levels.…”

Acquired Factor XII Deficiency in a Patient with Schizophrenia

“…Previous researches have shown that tuberculosis is associated with the hypercoagulable state as reflected by enhanced activation of coagulation factors VIII and V and moderate decreased of FXI and FX [12]. Secondly, lupus anticoagulant as a heterogeneous group of autoantibodies can induce acquired FXII deficiency [2].…”