Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
ÖzPurpose: Pediatric tuberculosis constitutes a significant part of the global burden of tuberculosis. It is also important in that it shows that the burden of tuberculosis continues in society. We here aimed to examine the epidemiologic features and treatment outcomes of pediatric pulmonary tuberculosis cases who were registered to the Adana Tuberculosis Dispensaries. Material and Methods: Fifty-six pediatric patients aged 0-18 years with the diagnosis of pulmonary tuberculosis were examined retrospectively in terms of demographic data, clinical characteristics and drug susceptibility test results, as well as treatment outcomes. Data were collected through medical record review. Results: The mean age of the patients was 12.84 ± 5.62 years and 46.4% were female. Nine patients (16%) were aged 0-5 years, 4 (7.1%) were aged 5-10 years, 17 (30.3%) were aged 10-15 years and 26 patients (46.4%) were aged 15-18 years. Fourty-eight children was only pulmonary tuberculosis whereas eight possessed characteristics of both pulmonary and extrapulmonary tuberculosis. The most frequent symptoms were prolonged cough (80.3%) and weight loss (73.2%). Drug susceptibility test was performed only 22 patients. Multidrug resistance was determined in one patient. Among the 56 children for whom treatment outcome was documented, 39 (69.6%) were completed treatment, 16 (28.5%) were cured and 1 (1.7%) had treatment failure. Conclusion:It was observed that the signs and symptoms of our patients were compatible with the literature. The epidemiological characterization of pediatric patients with pulmonary tuberculosis helps to provide a better diagnostic approach in this population. Amaç: Pediatrik tüberküloz dünya çapında tüberküloz yükünün önemli bir kısmını oluşturmaktadır. Pediatrik tüberküloz toplumda tüberküloz yükünün devam ettiğini göstermesi bakımından da önemlidir. Çalışmamızda Adana ili Tüberküloz Dispanserlerine kayıtlı olan pediatrik pulmoner tüberküloz olgularının epidemiyolojik özelliklerini ve tedavi sonuçlarını incelemeyi amaçladık. Gereç ve Yöntem: Pulmoner tüberküloz tanısı konan 0-18 yaş arası 56 çocuk demografik veriler, klinik özellikler, ilaç duyarlılık testi ve tedavi sonuçları açısından geriye dönük olarak incelenmiştir. Veriler tıbbi kayıtlardan elde edilmiştir. Bulgular: Yaş ortalaması 12,84 ± 5,62 olan olguların %46,4'ü kız idi. Sıfır-5 yaş arası 9 olgu (%16), 5-10 yaş arası 4 olgu (%7,1), 10-15 yaş arası 17 olgu (%30,3), 15-18 yaş arası 26 olgu (%46,4) vardı. Kırk sekiz çocukta sadece akciğer, sekizinde hem akciğer hem de akciğer dışı tutulum vardı. En sık görülen semptomlar uzun süren öksürük (%80,3) ve kilo kaybı (%73,2) idi. Sadece 22 hastaya ilaç duyarlılık testi uygulandı. Bir hastada çoklu ilaç direnci belirlendi. Tedavi sonuçları incelenen 56 çocuktan 39'u (%69,6) tedavisini tamamladı, 16'sında (%28,5) kür ve 1'inde (%1,7) tedavi başarısızlığı olduğu kaydedildi. Sonuç: Hastalarımızın belirti ve bulgularının literatür ile uyumlu olduğu gözlendi. Pediatrik pulmoner tüberküloz olgularının
ÖzPurpose: Pediatric tuberculosis constitutes a significant part of the global burden of tuberculosis. It is also important in that it shows that the burden of tuberculosis continues in society. We here aimed to examine the epidemiologic features and treatment outcomes of pediatric pulmonary tuberculosis cases who were registered to the Adana Tuberculosis Dispensaries. Material and Methods: Fifty-six pediatric patients aged 0-18 years with the diagnosis of pulmonary tuberculosis were examined retrospectively in terms of demographic data, clinical characteristics and drug susceptibility test results, as well as treatment outcomes. Data were collected through medical record review. Results: The mean age of the patients was 12.84 ± 5.62 years and 46.4% were female. Nine patients (16%) were aged 0-5 years, 4 (7.1%) were aged 5-10 years, 17 (30.3%) were aged 10-15 years and 26 patients (46.4%) were aged 15-18 years. Fourty-eight children was only pulmonary tuberculosis whereas eight possessed characteristics of both pulmonary and extrapulmonary tuberculosis. The most frequent symptoms were prolonged cough (80.3%) and weight loss (73.2%). Drug susceptibility test was performed only 22 patients. Multidrug resistance was determined in one patient. Among the 56 children for whom treatment outcome was documented, 39 (69.6%) were completed treatment, 16 (28.5%) were cured and 1 (1.7%) had treatment failure. Conclusion:It was observed that the signs and symptoms of our patients were compatible with the literature. The epidemiological characterization of pediatric patients with pulmonary tuberculosis helps to provide a better diagnostic approach in this population. Amaç: Pediatrik tüberküloz dünya çapında tüberküloz yükünün önemli bir kısmını oluşturmaktadır. Pediatrik tüberküloz toplumda tüberküloz yükünün devam ettiğini göstermesi bakımından da önemlidir. Çalışmamızda Adana ili Tüberküloz Dispanserlerine kayıtlı olan pediatrik pulmoner tüberküloz olgularının epidemiyolojik özelliklerini ve tedavi sonuçlarını incelemeyi amaçladık. Gereç ve Yöntem: Pulmoner tüberküloz tanısı konan 0-18 yaş arası 56 çocuk demografik veriler, klinik özellikler, ilaç duyarlılık testi ve tedavi sonuçları açısından geriye dönük olarak incelenmiştir. Veriler tıbbi kayıtlardan elde edilmiştir. Bulgular: Yaş ortalaması 12,84 ± 5,62 olan olguların %46,4'ü kız idi. Sıfır-5 yaş arası 9 olgu (%16), 5-10 yaş arası 4 olgu (%7,1), 10-15 yaş arası 17 olgu (%30,3), 15-18 yaş arası 26 olgu (%46,4) vardı. Kırk sekiz çocukta sadece akciğer, sekizinde hem akciğer hem de akciğer dışı tutulum vardı. En sık görülen semptomlar uzun süren öksürük (%80,3) ve kilo kaybı (%73,2) idi. Sadece 22 hastaya ilaç duyarlılık testi uygulandı. Bir hastada çoklu ilaç direnci belirlendi. Tedavi sonuçları incelenen 56 çocuktan 39'u (%69,6) tedavisini tamamladı, 16'sında (%28,5) kür ve 1'inde (%1,7) tedavi başarısızlığı olduğu kaydedildi. Sonuç: Hastalarımızın belirti ve bulgularının literatür ile uyumlu olduğu gözlendi. Pediatrik pulmoner tüberküloz olgularının
Introduction. Childhood tuberculosis (TB) is difficult to diagnosed and is based together on clinical and microbiology examinations. Since in children signs and symptoms of TB are not typical and sputum is difficult to be obtained, Mycobacterium tuberculosis (Mtb) antigen detection could be considered as a non invasive method for early detection of childhood TB. ESAT-6 is a low molecular weight specific protein that plays an important role in Mtb virulence. Aim. To determine the diagnostic value of urinary ESAT-6 for the diagnosis of childhood tuberculosis. Methodology.This was a cross-sectional study, with consecutive sampling collection . in children aging between 0-14 years suspected for pulmonary TB based on the clinical presence of :cough lasting more than 2 weeks, fever without clear ethiology, loss of body weight or poor weight gain, fatigue, malaise with positive history of contact with sputum smear from adult TB patients. Diagnosis of pulmonary TB was based on clinical presentation plus tuberculin positive skin test, chest x-ray, AFB staining and/or sputum culture. Subjects who met the inclusion criteria but unconfirmed by clinical and microbiological were considered as control (non-TB group). Urinary ESAT-6 level was analyzed by using ELISA. Cut off value and AUC was determined using ROC Statistical Analysis (SPSS 20.0). Sensitivity and specificity was measured from 2x2 crosstable. Result. Between the 61 studied children with suspected TB, 46/61 (75%) were finally diagnosed with TB, with 34/46 (74%) microbiologically confirmed cases either by sputum microscopy 31/34 (91%) or culture 3/34 (9%), whereas 15/61 (25%) subjects were not-confirmed cases (non-TB group). The mean value of urinary ESAT-6 level was higher in TB than non-TB group, Mean (SD) [4.855(6.714)] ng/mLvs [1.503(0.946)] ng/mL; p=<0.001(Mann-Whitney test). At ROC curve analysis ,the cut off value of urinary ESAT-6 in subjects TB confirmed both with clinical plus microbiology evaluation as reference standard was 1,91 ng/mL, with sensitivity 72% and specificity 67%. While the cut off value of ESAT-6 in TB subjects confirmed group only by clinical signs was 2.45 ng/mL, with sensitivity 65% and specificity 67%. Conclusion. For TB Diagnosis in Children, Urinary ESAT-6 urine could be considered of value when utilized in addition to microbiological tests and clinical examination.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.