Pulmonary Tuberculosis Associated with Membranous Nephropathy

Rodríguez-García, J L; Fraile, G.; Mampaso, F; Jl, Teruel

doi:10.1159/000185957

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…As remission took longer than 1-2 months in our case (approximately 5 months), it is more likely that tuberculosis played a major role in the development of MN. Reports on MN associated with tuberculosis are relatively scarce [15,16]. In one report, a 66-year-old man with nephrotic syndrome had biopsy-proven MN [15].…”

Section: Discussionmentioning

confidence: 99%

“…Reports on MN associated with tuberculosis are relatively scarce [15,16]. In one report, a 66-year-old man with nephrotic syndrome had biopsy-proven MN [15]. Diuretics and prednisone (40 mg daily, orally) were ineffective, and consequently, his renal function deteriorated.…”

Section: Discussionmentioning

confidence: 99%

“…Infections commonly associated with MN include hepatitis B and hepatitis C [1]. Cases of MN associated with tuberculosis are quite rare [15][16][17][18]. In a previous study, a case of MN associated with pulmonary tuberculosis was reported, where anti-tuberculosis treatment resolved proteinuria without the use of immunosuppressants [17].…”

Section: Introductionmentioning

confidence: 99%

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Membranous nephropathy in a patient with pulmonary tuberculosis infection and lung adenocarcinoma: a case report

et al. 2021

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We report a case of membranous nephropathy (MN) in a patient with tuberculosis infection and lung adenocarcinoma. A 50-year-old Filipino woman underwent a renal biopsy for the evaluation of proteinuria and hematuria. Immunofluorescence analysis revealed positive staining of IgG in the glomerular basement membrane and mesangial matrices, while electron microscopy demonstrated the presence of sub-epithelial deposits, suggesting MN. To screen for secondary causes of MN, we conducted a computed tomography (CT) scan of the chest and abdomen, which revealed a ground-glass opacity in the middle lobe of the right lung and an enlarged paraaortic lymph node. A T-SPOT test was positive, suggesting the possibility of a latent tuberculosis infection, as she was asymptomatic. A follow-up chest CT scan showed persistent presence of the ground-glass opacities, suggesting a non-infectious cause. Video-assisted thoracoscopic resection of the middle right lobe and partial resection of the lower right lobe were performed because the possibility of lung cancer could not be excluded. Notably, pathological analysis of the lung revealed adenocarcinoma in the middle lobe and epithelioid granuloma in the lower lobe, suggesting an active tuberculosis infection. One month after surgery, anti-tuberculosis treatment was initiated. Thereafter, her proteinuria, which had increased to 6 g/gCre preoperatively, began to decrease. Five months after surgery, the patient achieved complete remission. The speed of remission suggests that tuberculosis likely played a primary role in the etiology of MN. Our case underscores the importance of screening tests for infections and malignancies in patients with MN, even if suggestive symptoms are absent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Membranous nephropathy in a patient with pulmonary tuberculosis infection and lung adenocarcinoma: a case report

et al. 2021

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“…But evidence of tuberculous infection causing membranous glomerulopathy are very few [5,8,9]. The association of membranous glomerulonephritis with tuberculosis infection in the form of peritonitis is unique and has not been documented in the literature so far to date.…”

Section: Discussionmentioning

confidence: 99%

Membranous glomerulonephritis and tuberculous peritonitis: a rare association

Ghosh¹,

Pande

Ghosh³

et al. 2011

J Infect Dev Ctries

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“…Meyrier et al described the association between membranoproliferative GN in the course of disseminated tuberculosis 17 ) . Rodriguez-Garcia et al experienced a patient with pulmonary tuberculosis and membranous nephropathy 18 ) . As in earlier reported cases, a coincidence between a common disease, such as tuberculosis, and a systemic vasculitis such as HSP should be considered.…”

Section: Discussionmentioning

confidence: 99%

A Case of Henoch-Schonlein Purpura in Disseminated Tuberculosis

Han

Choi

Shin

et al. 1995

Korean J Intern Med

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Tuberculosis is still a common disease, even in some parts of developing countries. Although its major impact is pulmonary, the tuberculosis is actually a disseminated disease. An unusual form of renal involvement of tuberculosis is glomerulonephritis, as a part of systemic vasculitis, Henoch-Schönlein Purpura (HSP). A 41-year-old man, being treated with antituberculous agents for pulmonary tuberculosis, was transferred to our hospital because of newly developed generalized purpura and pretibial edema. Renal manifestations were proteinuria and hematuria. Renal biopsy disclosed interstitial chronic granulomatous inflammation with caseous necrosis and strong nodular mesangial Ig A deposit, along with trace granular Ig G deposition and perivascular C3 deposit. Skin lesions were nonthrombocytopenic palpable purpurae, proved leukocy toclastic vasculitis by skin biopsy. All clinical symptoms and signs were relieved by antituberculous medication.We concluded that disseminated tuberculosis might be a cause of HSP, an immune complex mediated disease.

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Pulmonary Tuberculosis Associated with Membranous Nephropathy

Cited by 7 publications

References 3 publications

Membranous nephropathy in a patient with pulmonary tuberculosis infection and lung adenocarcinoma: a case report

Membranous nephropathy in a patient with pulmonary tuberculosis infection and lung adenocarcinoma: a case report

Membranous glomerulonephritis and tuberculous peritonitis: a rare association

A Case of Henoch-Schonlein Purpura in Disseminated Tuberculosis

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