Pulmonary tuberculosis and lung cancer: A complex interaction

Mejri, Insaf; Ourari, B.; Cherif, H.; Amar, J. Ben; Zaibi, H.; Azzabi, S.; Baccar, M.A.; Aouina, H.

doi:10.1183/13993003.congress-2016.pa3721

Cited by 3 publications

(2 citation statements)

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“…The role of microbiome in lung cancer is ill defined. Since the inflammatory responses is linked with the lung cancer development [70], some studies documented that infections such as tuberculosis or pneumonia increase the risk of lung cancer [71]. Although some discrepancies exist, two bacterial genera (Veillonella and Megasphaera) have been found to be increased significantly in lung cancer patients [72]; Yan et al [73] demonstrated that the salivary microbiome was different in lung cancer patients compared with controls, suggesting the salivary microbiome as a potential bacterial biomarker of lung cancer.…”

Section: Microbiota and Lung Cancermentioning

confidence: 99%

The lung microbiome: clinical and therapeutic implications

et al. 2019

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The human respiratory tract, usually considered sterile, is currently being investigated for human-associated microbial communities. According to Dickson's conceptual model, the lung microbiota (LMt) is a dynamic ecosystem, whose composition, in healthy lungs, is likely to reflect microbial migration, reproduction, and elimination. However, which microbial genera constitutes a "healthy microbiome" per se remains hotly debated. It is now widely accepted that a bi-directional gut-lung axis connects the intestinal with the pulmonary microbiota and that the diet could have a role in modulating both microbiotas as in health as in pathological status. The LMt is altered in numerous respiratory disorders such as obstructive airway diseases, interstitial lung diseases, infections, and lung cancer. Some authors hypothesize that the use of specific bacterial strains, termed "probiotics," with positive effects on the host immunity and/or against pathogens, could have beneficial effects in the treatment of intestinal disorders and pulmonary diseases. In this manuscript, we have reviewed the literature available on the LMt to delineate and discuss the potential relationship between composition alterations of LMt and lung diseases. Finally, we have reported some meaningful clinical studies that used integrated probiotics' treatments to contrast some lung-correlated disorders.

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Section: Microbiota and Lung Cancermentioning

confidence: 99%

The lung microbiome: clinical and therapeutic implications

et al. 2019

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“…Given the potential for TB infections to be foci for inflammation a possible link with LC was suspected but only recently has been supported by clinical studies [ 30 ]. A recent Danish study compared the cancer risk in TB patients during 1978–2011 with the general population and noted a significantly increased risk of LC [ 48 ].…”

Section: Microbial Associations With Lung Cancermentioning

confidence: 99%

Lung cancer: a new frontier for microbiome research and clinical translation

Mur

Huws

Cameron

et al. 2018

ecancer

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The lung microbiome has been shown to reflect a range of pulmonary diseases—for example: asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Studies have now begun to show microbiological changes in the lung that correlate with lung cancer (LC) which could provide new insights into lung carcinogenesis and new biomarkers for disease screening. Clinical studies have suggested that infections with tuberculosis or pneumonia increased the risk of LC possibly through inflammatory or immunological changes. These have now been superseded by genomic-based microbiome sequencing studies based on bronchoalveolar lavage, sputum or saliva samples. Although some discrepancies exist, many have suggested changes in particular bacterial genera in LC samples particularly, Granulicatella, Streptococcus and Veillonella. Granulicatella is of particular interest, as it appeared to show LC stage-specific increases in abundance. We propose that these microbial community changes are likely to reflect biochemical changes in the LC lung, linked to an increase in anaerobic environmental niches and altered pyridoxal/polyamine/nitrogenous metabolism to which Granulicatella could be particularly responsive. These are clearly preliminary observations and many more expansive studies are required to develop our understanding of the LC microbiome.

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