“…The differentiation process is MYB‐independent and associated with HOXA expression (Buchrieser, James, & Moore, 2017; Dou et al., 2016; Ivanovs et al., 2017; Ng et al., 2016; Vanhee et al., 2015), indicating this recapitulates primitive hematopoiesis in vivo. Other studies found that hiPSC‐derived macrophages (iPSDMs) could acquire tissue‐specific characteristics in vitro (Takata et al., 2017) and in vivo (Happle et al., 2018; Takata et al., 2017) by coculture with other tissue‐resident cell types. All of these studies indicate that iPSDMs can be a unique source of patient‐specific, tissue‐resident macrophages given that they can be produced in unlimited cell numbers from a renewable donor source of choice and can adopt a tissue resident macrophage‐like identity.…”