Pulmonary toxicology assessment of polyethylene terephthalate nanoplastic particles in vitro

Zhang, Huajing; Zhang, Shuyi; Duan, Zhenghua; Wang, Lei

doi:10.1016/j.envint.2022.107177

Cited by 52 publications

(22 citation statements)

References 23 publications

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“…The cytotoxicity of MNPs has been evaluated by analyzing cell viability, intracellular ROS levels, mitochondrial membrane potential levels, and apoptosis in human pulmonary cells [ 56 ]. The major mechanism of the toxic effect of MNPs on cells may be the increase in ROS caused by oxidative stress, which in turn leads to a decrease in mitochondrial membrane potential.…”

Section: Toxicities Of Micro- and Nanoplastics On Mitochondriamentioning

confidence: 99%

Impact of Micro- and Nanoplastics on Mitochondria

Lee

Moon

et al. 2022

Metabolites

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Mitochondria are highly dynamic cellular organelles that perform crucial functions such as respiration, energy production, metabolism, and cell fate decisions. Mitochondrial damage and dysfunction critically lead to the pathogenesis of various diseases including cancer, diabetes, and neurodegenerative and cardiovascular disorders. Mitochondrial damage in response to environmental contaminant exposure and its association with the pathogenesis of diseases has also been reported. Recently, persistent pollutants, such as micro- and nanoplastics, have become growing global environmental threats with potential health risks. In this review, we discuss the impact of micro- and nanoplastics on mitochondria and review current knowledge in this field.

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Section: Toxicities Of Micro- and Nanoplastics On Mitochondriamentioning

confidence: 99%

Impact of Micro- and Nanoplastics on Mitochondria

Lee

Moon

et al. 2022

Metabolites

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“…The cytotoxic effect of PS nanoplastics in the high concentration was explained by the direct damaging the mitochondrial inner membrane (Halimu et al 2022). In another study, the impact of PET concentration on the cell viabilities of A549 was examined and, at lower concentration, PET particles showed limited inhibition compared to higher concentrations (e.g., > 100 µg/mL of plastics) (Zhang et al 2022). Since, at low concentrations (< 50 µg/mL) of plastic particles, the active substances produced by the cells may reduce the stress responses.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the main potential sources of micro(nano)plastics for humans can be the contamination of bottled water and indoor/outdoor air dusts Akhbarizadeh et al 2021). These potential sources can mainly accumulate polyethylene terephthalate (PET) typed micro(nano)plastics compared to other polymer types and recent eld studies have approved this situation (Zhang et al 2022). For example, examined the occurrences of PET and polycarbonate (PC) type plastics in indoor and outdoor samples in China and the study indicated that PET and PC microplastics are widespread in indoor and outdoor dusts ).…”

Section: Introductionmentioning

confidence: 99%

Understanding the interaction of micro(nano)plastics with simulated saliva, lysosomal and Gamble’s fluids and their impact on human lung epithelial A549 cells

Saygın

Soyocak

Baysal

et al. 2022

Preprint

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Micro(nano)plastics are considered an emerging threat to human health since they have potential to interact with biological systems and already been found in the human body, e.g., lungs. However, limited data is available for their behavior under biological conditions and impact on human cells, specifically alveolar epithelial cells. In this study, micro(nano)plastics weathered to various simulated biological fluids (saliva, artificial lysosomal fluids, Gamble’s solution) during 2 h to 80 h. Pristine and weathered plastic particles were characterized by their surface chemistry, zeta potentials, and elemental composition. After, various toxicological endpoints (mitochondrial membrane potential, lactate dehydrogenase, protein, and antioxidant levels) were examined through A549 lung carcinoma cells. The surface characteristics of micro(nano)plastics and the toxicological endpoints of A549 were influenced by the simulated biological weathering, specifically at high concentration of micro(nano)plastics and increasing exposure under biological conditions. The results also indicated that toxicological endpoints had strong linked with the chemistry of plastics and included the multiple processes to the response of the plastics, for instance, the cell membrane integrity and mitochondrial activity were declined with the micro(nano)plastics under saliva weathering, contrarily, their protein and antioxidant activities increased. However, different biological pathways were obtained under artificial lysosomal fluid and Gamble’s solution.

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“…After absorption, NPs can diffuse systemically and can accumulate in a variety of tissues and organs: the presence of NPs has been detected in lungs, blood, brain, and portions of the gastrointestinal system [ 5 , 6 , 7 ]. NPs are two orders of magnitude smaller than eukaryote cells; thus, they can also be internalized by cells [ 8 ] through different mechanisms depending on the particle size: smaller particles can enter the cell under passive diffusion and pinocytosis [ 9 , 10 ], and larger NPs can cross cell membranes via receptor-mediated pathways, such as clathrin-mediated endocytosis and caveolin-mediated endocytosis [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…The authors did not observe any major conformational change in the protein structure because of the biding. Recently, Kalipillaia et al [ 8 ] studied the interaction of amyloidogenic protein amyloid β (Aβ40) with AuNPs (3–5 nm in diameter) and characterized residue-specific contacts and the effects on the secondary structure of the protein, finding that AuNPs reduce the formation of beta sheets, thus preventing the formation of mature fibers.…”

Section: Introductionmentioning

confidence: 99%

In Silico Analysis of Nanoplastics’ and β-amyloid Fibrils’ Interactions

et al. 2023

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Plastic pollution has become a global environmental threat, which leads to an increasing concern over the consequences of plastic exposition on global health. Plastic nanoparticles have been shown to influence the folding of proteins and influence the formation of aberrant amyloid proteins, therefore potentially triggering the development of systemic and local amyloidosis. This work aims to study the interaction between nanoplastics and β-amyloid fibrils to better understand the potential role of nanoplastics in the outbreak of neurodegenerative disorders. Using microsecond-long coarse-grained molecular dynamics simulations, we investigated the interactions between neutral and charged nanoparticles made of the most common plastic materials (i.e., polyethylene, polypropylene, and polystyrene) and β-amyloid fibrils. We observe that the occurrence of contacts, region of amyloid fibril involved, and specific amino acids mediating the interaction depend on the type and charge of the nanoparticles.

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Pulmonary toxicology assessment of polyethylene terephthalate nanoplastic particles in vitro

Cited by 52 publications

References 23 publications

Impact of Micro- and Nanoplastics on Mitochondria

Impact of Micro- and Nanoplastics on Mitochondria

Understanding the interaction of micro(nano)plastics with simulated saliva, lysosomal and Gamble’s fluids and their impact on human lung epithelial A549 cells

In Silico Analysis of Nanoplastics’ and β-amyloid Fibrils’ Interactions

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