Pulmonary toxicity with mefloquine

Udry, E.; Bailly, François; Dusmet, Michael; Schnyder, P; Lemoine, Rémy C.; Jw, Fitting

doi:10.1183/09031936.01.00208001

Cited by 15 publications

(7 citation statements)

References 10 publications

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“…Mefloquine has been associated with subacute cellular interstitial pneumonitis and acute respiratory distress syndrome, whereas pyrimethamine has been associated with eosinophilic pneumonia. [7][8][9][10]22…”

Section: Discussionmentioning

confidence: 99%

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Dr. Mefloquine‐Induced Eosinophilic Pneumonia

et al. 2007

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Mefloquine has been widely used for prophylaxis and treatment of patients with chloroquine-resistant malaria; the drug is usually well tolerated. Rarely, adverse effects may be severe, including gastrointestinal disturbances, neuropsychiatric reactions, cardiovascular manifestations, skin lesions, musculoskeletal symptoms, and bone marrow toxicity. We describe a 67-year-old woman with fever, dyspnea on exertion, peripheral blood eosinophilia, and diffuse pulmonary infiltrates on chest radiography. She had taken mefloquine for malaria prophylaxis for an 8-week trip to South Africa. A thorough work-up led to the diagnosis of eosinophilic pneumonia caused by the mefloquine. Her condition improved after the drug was discontinued. To our knowledge, this is the first report of mefloquine-induced eosinophilic pneumonia. Clinicians should be aware of this rare, potential adverse effect of mefloquine.

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Section: Discussionmentioning

confidence: 99%

“…5,6 Furthermore, few recent reports have been published regarding acute lung injury with diffuse alveolar damage attributed to mefloquine. [7][8][9][10] We describe a case of mefloquine-induced eosinophilic pneumonia in a traveler who went to sub-Saharan Africa.…”

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confidence: 99%

Dr. Mefloquine‐Induced Eosinophilic Pneumonia

et al. 2007

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“…One noteworthy aspect is the pulmonary toxicity that may be produced by the use of mefloquine, with the development of diffuse alveolar damage [186][187][188]. …”

Section: Genus Plasmodiummentioning

confidence: 99%

Protozoa in respiratory pathology: a review

Martínez‐Girón¹,

Esteban²,

Ribas³

et al. 2008

European Respiratory Journal

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Among the micro-organisms that may affect the respiratory apparatus are the protozoa. The diseases they may give rise to constitute a relatively uncommon group of respiratory ailments with, in the majority of cases, an underlying clinical situation corresponding to states of suppressed immunity (AIDS, transplants, malign haemopathies, corticotherapy, etc.). Other factors, such as visits to endemic areas and immigration, also have to be taken into account.In view of the probable increase in the number of cases and the appearance of new emerging diseases, it is the intention of the present work to review the publications available, in different fields of medicine, that refer to the principal kinds of protozoa (Entamoeba,

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“…Furthermore, severe postural orthostatic tachycardia syndrome including symptoms of palpitations and dizziness, loss of R-R interval variation, typical of autonomic dysfunction, were reported in a case study of a woman taking MF as an anti-malarial [5]. MF may have further consequences, as respiratory complications including dyspnoea and respiratory distress have been ascribed to MF in case studies of patients treated for malaria [6,7]. …”

Section: Introductionmentioning

confidence: 99%

The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

et al. 2012

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BackgroundMefloquine is an anti-malarial drug that can have neurological side effects. This study examines how mefloquine (MF) influences central nervous control of autonomic and respiratory systems using the arterially perfused working heart brainstem preparation (WHBP) of the rat. Recordings of nerve activity were made from the thoracic sympathetic chain and phrenic nerve, while heart rate (HR) and perfusion pressure were also monitored in the arterially perfused, decerebrate, rat WHBP. MF was added to the perfusate at 1 μM to examine its effects on baseline parameters as well as baroreceptor and chemoreceptor reflexes.ResultsMF caused a significant, atropine resistant, bradycardia and increased phrenic nerve discharge frequency. Chemoreceptor mediated sympathoexcitation (elicited by addition of 0.1 ml of 0.03% sodium cyanide to the aortic cannula) was significantly attenuated by the application of MF to the perfusate. Furthermore MF significantly decreased rate of return to resting HR following chemoreceptor induced bradycardia. An increase in respiratory frequency and attenuated respiratory-related sympathetic nerve discharge during chemoreceptor stimulation was also elicited with MF compared to control. However, MF did not significantly alter baroreceptor reflex sensitivity.ConclusionsThese studies indicate that in the WHBP, MF causes profound alterations in autonomic and respiratory control. The possibility that these effects may be mediated through actions on connexin 36 containing gap junctions in central neurones controlling sympathetic nervous outflow is discussed.

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Pulmonary toxicity with mefloquine

Cited by 15 publications

References 10 publications

Dr. Mefloquine‐Induced Eosinophilic Pneumonia

Dr. Mefloquine‐Induced Eosinophilic Pneumonia

Protozoa in respiratory pathology: a review

The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat

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