2015
DOI: 10.1007/s11051-015-3249-1
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Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation

Abstract: We performed inhalation and intratracheal instillation studies of cerium dioxide (CeO2) nanoparticles in order to investigate their pulmonary toxicity, and observed pulmonary inflammation not only in the acute and but also in the chronic phases. In the intratracheal instillation study, F344 rats were exposed to 0.2 mg or 1 mg of CeO2 nanoparticles. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed from 3 days to 6 months following the instillation. In the inhalation study, rats … Show more

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Cited by 69 publications
(94 citation statements)
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References 30 publications
(43 reference statements)
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“…Relevant to this finding, a significant increase of WBCs, neutrophils, lymphocytes, and monocytes in hematology tests was observed in the same groups. Several cases of granulomatous inflammation in the lung were reported in recent toxicity studies using CeO 2 nanoparticles (Toya et al, ; Srinivas et al, ; Aalapati et al, ; Keller et al, ; Peng et al, ), and these were caused by oxidative stress (Srinivas et al, ; Peng et al, ; Hong et al, ; Morimoto et al, ). Specifically, Peng et al () reported that a single intratracheal instillation of CeO 2 nanoparticles to mice caused two waves of lung injury: BAL inflammation and cytotoxicity in the early stage and redox‐activity‐evoked lipid peroxidation, as well as proinflammation in the latter stage.…”
Section: Discussionmentioning
confidence: 99%
“…Relevant to this finding, a significant increase of WBCs, neutrophils, lymphocytes, and monocytes in hematology tests was observed in the same groups. Several cases of granulomatous inflammation in the lung were reported in recent toxicity studies using CeO 2 nanoparticles (Toya et al, ; Srinivas et al, ; Aalapati et al, ; Keller et al, ; Peng et al, ), and these were caused by oxidative stress (Srinivas et al, ; Peng et al, ; Hong et al, ; Morimoto et al, ). Specifically, Peng et al () reported that a single intratracheal instillation of CeO 2 nanoparticles to mice caused two waves of lung injury: BAL inflammation and cytotoxicity in the early stage and redox‐activity‐evoked lipid peroxidation, as well as proinflammation in the latter stage.…”
Section: Discussionmentioning
confidence: 99%
“…instillation or inhalation CeO 2 NPs [1518, 42]. However, as far as we are aware, no study has investigated systematically the oxidative stress (LPO, ROS, SOD, GSH, and total NO), inflammation (TNF- α , IL-6, and IL-1 β ), and DNA damage in the lung and important secondary organs including heart, liver, kidney, spleen, and brain.…”
Section: Discussionmentioning
confidence: 99%
“…Inhalation of CeO 2 induced pulmonary inflammation in a concentration-dependent manner with post-exposure persistency [3, 17, 22, 23]. Respective studies further indicated distribution of cerium to extra-pulmonary organs [16, 17, 22] and impaired nanoparticle clearance at high dose levels (≥ 5 mg/m 3 ) [16, 17].…”
Section: Introductionmentioning
confidence: 99%