Pulmonary toxicity following gastrointestinal ingestion of kerosene

Dice, William H.; Ward, George Gray; Kelley, James A.; Kilpatrick, William R.

doi:10.1016/s0196-0644(82)80239-4

Cited by 34 publications

(12 citation statements)

References 33 publications

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“…Symptomatic involvement of the respiratory tract is the most common complication of HC ingestion, occurring in approximately 40% of patients [4,9,[13][14][15]. Pulmonary lesions are not caused by gastrointestinal absorption but rather by aspiration [5,6,[16][17][18][19][20], which usually occurs at the time of the initial swallowing or as a consequence of vomiting. The amount of HC that has been ingested by a child is often difficult to quantify.…”

Section: Discussionmentioning

confidence: 99%

Pneumonitis and pneumatoceles following accidental hydrocarbon aspiration in children

Thalhammer

Eber

Zach

2005

Wien Klin Wochenschr

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Accidental ingestion and aspiration of hydrocarbons in children are common. Among the various clinical and pathological manifestations of hydrocarbon (HC) poisoning, pneumonitis is the most significant and occurs in up to 40% of children, whereas formation of pneumatoceles is believed to be a rare event. We report two children with HC pneumonitis and pneumatoceles as a reversible complication after ingestion and aspiration of lamp oil with very low viscosity. Patient 1, a 21-month-old boy, started to cough and developed tachypnea, sternal retractions and mild cyanosis immediately after aspiration. Patient 2, a 24-month-old girl, was asymptomatic during the first days after the accident; subsequently, she started to cough and developed fever, dyspnea and chest pain. Chest x-ray and computed tomography revealed multiple patchy infiltrates in both cases; after several days, these confluent infiltrates developed into pneumatoceles. Both children were treated with antibiotics and steroids. They recovered within three and four weeks, respectively, with complete remission of the radiologic abnormalities and had an uneventful follow-up after discharge.

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Section: Discussionmentioning

confidence: 99%

Pneumonitis and pneumatoceles following accidental hydrocarbon aspiration in children

Thalhammer

Eber

Zach

2005

Wien Klin Wochenschr

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“…Although reports of petroleum hydrocarbon exposure in humans [8][9][10][11][12][13][14], primates [15], and several other species, including ruminants [16][17][18][19][20][21][22][23][24][25][26], horses [27], wildlife [28], and a dog [29], have been cited in the literature, there are few reports on exposure of animals to gas operations, and to our knowledge, no case reports on exposure of humans to hydrocarbon gas operations [30]. Adler et al [31] observed aspiration pneumonia in sheep following exposure to gas condensate.…”

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confidence: 99%

Impacts of Gas Drilling on Human and Animal Health

Bamberger¹,

Oswald²

2012

New Solut

195

131

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Environmental concerns surrounding drilling for gas are intense due to expansion of shale gas drilling operations. Controversy surrounding the impact of drilling on air and water quality has pitted industry and lease-holders against individuals and groups concerned with environmental protection and public health. Because animals often are exposed continually to air, soil, and groundwater and have more frequent reproductive cycles, animals can be used as sentinels to monitor impacts to human health. This study involved interviews with animal owners who live near gas drilling operations. The findings illustrate which aspects of the drilling process may lead to health problems and suggest modifications that would lessen but not eliminate impacts. Complete evidence regarding health impacts of gas drilling cannot be obtained due to incomplete testing and disclosure of chemicals, and nondisclosure agreements. Without rigorous scientific studies, the gas drilling boom sweeping the world will remain an uncontrolled health experiment on an enormous scale.

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“…Many workers support direct aspiration during ingestion or subsequent vomiting, either spontaneous or induced (10,13,16,19,32,44,56,58) whereas others favor gastrointestinal absorption (2, 12, 52). Because hydrocarbons are lipid solvents, cell membrane disruption (2,35) has been proposed as mechanism for cell injury.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Clearance of Staphylococcus Aureus and Plasma Angiotensin-Converting Enzyme Activity in Hydrocarbon Pneumonitis

et al. 1983

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SummaryPulmonary clearance of Staphylococcus aureus and plasma angiotensin-converting enzyme (ACE) activity were investigated in an experimental mouse model of kerosene aspiration. Twenty-four hours after acute kerosene aspiration, mice were exposed for 30 min to an aerosol containing the pathogen, and the uncleared bacteria ratio (UBR) determined 4 h after nebulization. The results showed a significant increase (P = 0.004) in UBR in animals with severe pneumonitis (0.44 + 0.05) when compared with controls (0.24 + 0.03). This impairment in lung clearance correlated with the increase in lung weight and the decrease in plasma ACE levels. Mice with kerosene pneumonitis had zones of lung injury, and areas with no gross signs of tissue damage. Lung clearance of S. aureus was significantly impaired in damaged areas whereas it was no different from controls in the non-affected areas. It is suggested that the measurement of plasma ACE activity may be an adjunct in the assessment of the extent of lung injury in hydrocarbon aspiration in children.

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Pulmonary toxicity following gastrointestinal ingestion of kerosene

Cited by 34 publications

References 33 publications

Pneumonitis and pneumatoceles following accidental hydrocarbon aspiration in children

Pneumonitis and pneumatoceles following accidental hydrocarbon aspiration in children

Impacts of Gas Drilling on Human and Animal Health

Pulmonary Clearance of Staphylococcus Aureus and Plasma Angiotensin-Converting Enzyme Activity in Hydrocarbon Pneumonitis

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