‘Pulmonary thrombosis in situ’: risk factors, clinic characteristics and long-term evolution

Fletcher‐Sanfeliu, Delfina; Redón, Josep; García-Granero, Álvaro; Frasson, Matteo; Barreira, Ignacio; Martínez-León, Juan; García-Fuster, María José

doi:10.1097/mbc.0000000000000949

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…On the other hand, lung trauma and congenital or acquired abnormalities in lung structures are considered high risk factors of in situ PAT ( Van Gent et al, 2014 ; Fletcher-Sanfeliu et al, 2020 ) ( Figure 1 ). Experimental studies have shown that chest trauma may induce focal inflammation and dysfunction in pulmonary vascular endothelial cells, eliciting in situ PAT ( Knudson et al, 2011 ; Brakenridge et al, 2013 ) ( Figure 1 ).…”

Section: The Risk Factors Of Pulmonary Thromboembolism Associated With Deep Vein Thrombosis and Of In Situ Pulmonary Amentioning

confidence: 99%

In situ Pulmonary Artery Thrombosis: A Previously Overlooked Disease

Cao

Geng

et al. 2021

Front. Pharmacol.

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Pulmonary thromboembolism (PTE) is the third leading cause of death in cardiovascular diseases. PTE is believed to be caused by thrombi detached from deep veins of lower extremities. The thrombi travel with systemic circulation to the lung and block pulmonary arteries, leading to sudden disruption of hemodynamics and blood gas exchange. However, this concept has recently been challenged by accumulating evidence demonstrating that de novo thrombosis may be formed in pulmonary arteries without deep venous thrombosis. On the other hand, chronic thromboembolic pulmonary hypertension (CTEPH), a subtype of pulmonary hypertension, could have different pathogenesis than traditional PTE. Therefore, this article summarized and compared the risk factors, the common and specific pathogenic mechanisms underlying PTE, in situ pulmonary artery thrombosis, and CTEPH at molecular and cellular levels, and suggested the therapeutic strategies to these diseases, aiming to facilitate understanding of pathogenesis, differential diagnosis, and precision therapeutics of the three pulmonary artery thrombotic diseases.

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Section: The Risk Factors Of Pulmonary Thromboembolism Associated With Deep Vein Thrombosis and Of In Situ Pulmonary Amentioning

confidence: 99%

In situ Pulmonary Artery Thrombosis: A Previously Overlooked Disease

Cao

Geng

et al. 2021

Front. Pharmacol.

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“…The factor V Leiden mutation is more strongly correlated to risk of DVT, 12 while cardiac diseases have been shown to be a stronger risk for PE, which might also be the case for pulmonary conditions such as chronic obstructive pulmonary disease (COPD). 12 , 13 Previous studies on differences are either small, 14 , 15 are exclusively based on old data, 5 , 12 , 16 or only evaluated a limited number of comorbidities. 13 , 17 Given the difference in severity and mortality between PE and DVT, there is a need for a large, comprehensive study focusing on differences between patients with PE and patients with DVT.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary embolism and deep vein thrombosis—comorbidities and temporary provoking factors in a register‐based study of 1.48 million people

Sandblad

Rosengren

Sörbo

et al. 2022

Research and Practice in Thrombosis and Haemostasis

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Background Knowledge on differences in patients who present with deep vein thrombosis (DVT) and those with pulmonary embolism (PE) is incomplete. Objective To determine comorbidities and temporary provoking factors in patients with a first‐time PE or DVT. Methods This was a nationwide Swedish registry‐based, retrospective, case‐control study including 298 172 patients with first‐time venous thromboembolism (VTE) and 1 185 079 controls matched for age, sex, and county of residence, free of VTE at the time of matching. Results Patients with PE were older than those with DVT (mean age, 69 vs 66 years) and included slightly more women (PE, 53.4% vs DVT, 52.1%). After multivariable adjustment for comorbidities (within 7 years) and temporary provoking factors (within 3 months), heart failure (PE: adjusted odds ratio [aOR], 2.64 [99% confidence interval [CI], 2.55‐2.73]; DVT: aOR, 1.66 [99% CI, 1.60‐1.72]), ischemic heart disease (PE: aOR, 1.51 [99% CI, 1.47‐1.56]; DVT: aOR, 1.01 [99% CI, 0.98‐1.04]), and chronic obstructive pulmonary disease (PE: aOR, 2.51 [99% CI, 2.40‐2.63]; DVT, 1.54 [99% CI, 1.47‐1.62]) were among diseases that showed higher odds ratios in patients with PE than in those with DVT, compared with controls. Comorbidities registered within 6 months were associated with higher aORs than those within 7 years. The highest population attributable risks for PE were for cancer (13.0%) and heart failure (11.7%). Conclusion Cardiopulmonary diseases, particularly with recent onset, imply a higher risk for PE, whereas orthopedic surgery and lower‐extremity fractures carry a higher risk of DVT.

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“…Although it is not possible for us to definitively prove that the PE arose from an SST locus, we propose that there is a high likeli hood that the clot originated from the sigmoid given that these patients did not have any evidence of extremity DVT and had imaging demonstrating residual clot in the sigmoid. A de novo pulmonary embolism is another possibility; how ever, patients who develop de novo pulmonary embolisms often have multiple medical comorbidities, 26 which were not present in our patients.…”

Section: Discussionmentioning

confidence: 79%

Pulmonary Embolism and Sigmoid Sinus Thrombosis After Translabyrinthine Vestibular Schwannoma Resection: A Retrospective Case Series

Song

Ayoub

Chen

et al. 2021

Ann Otol Rhinol Laryngol

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Objective: To describe the presentation and treatment of patients developing pulmonary embolism following translabyrinthine approach for vestibular schwannoma resection. Methods: This was a retrospective case series of patients at 2 academic tertiary medical centers who developed symptomatic pulmonary embolism post-operatively following translabyrinthine approach for vestibular schwannoma resection and were found to have evidence of sigmoid sinus thrombosis. Results: Three patients were identified to have post-operative pulmonary emboli after translabyrinthine approach for vestibular schwannoma resection with sigmoid sinus or internal jugular vein clots in the absence of lower extremity deep vein thrombosis. Caprini scores for these patients were 5 or lower. All patients underwent CT pulmonary angiography and were confirmed to have pulmonary emboli. Two were promptly anticoagulated with heparin drips and transitioned to long-term oral anticoagulation therapy and 1 had delayed anticoagulation. None of these patients suffered from intracranial hemorrhage post-operatively. Conclusions: Patients undergoing translabyrinthine approach for vestibular schwannoma can develop pulmonary embolism from sigmoid sinus entry or thrombosis. No clear guidelines exist for the management of this complication in the setting of recent craniotomy and the risk of intracranial hemorrhage must be considered prior to initiating anticoagulation.

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‘Pulmonary thrombosis in situ’: risk factors, clinic characteristics and long-term evolution

Cited by 9 publications

References 30 publications

In situ Pulmonary Artery Thrombosis: A Previously Overlooked Disease

In situ Pulmonary Artery Thrombosis: A Previously Overlooked Disease

Pulmonary embolism and deep vein thrombosis—comorbidities and temporary provoking factors in a register‐based study of 1.48 million people

Pulmonary Embolism and Sigmoid Sinus Thrombosis After Translabyrinthine Vestibular Schwannoma Resection: A Retrospective Case Series

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