Pulmonary strongyloidiasis associated CD3+ large granular lymphocytosis

Rishi, Muhammad Adeel; Chaudhry, Saleha Z.

doi:10.4103/1817-1737.78432

Cited by 2 publications

(2 citation statements)

References 11 publications

(19 reference statements)

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“…[67] Pulmonary strongyloidiasis is a common manifestation of the Strongyloides hyperinfection syndrome. [8] Air space consolidation, pleural effusion, pulmonary hemorrhage, lung abscess and ARDS have been reported with strongyloidiasis. [9–11]…”

Section: Discussionmentioning

confidence: 99%

Hyperinfection with Strongyloides in a HIV-negative elderly male

et al. 2012

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Strongyloides stercoralis is an intestinal nematode producing mild infection in the immunocompetent and fatal hyperinfection syndrome in the immunocompromised. An elderly HIV-negative male presented with symptoms of chronic respiratory disease and vague abdominal symptoms. Examination of sputum and stools showed larvae of S. stercoralis. Bacterial and fungal causes of respiratory infections were ruled out. The patient responded to oral ivermectin.

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Section: Discussionmentioning

confidence: 99%

Hyperinfection with Strongyloides in a HIV-negative elderly male

et al. 2012

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“…Cases of LGL expansion secondary to Epstein Bar virus (EBV), cytomegalovirus (CMV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Human immunodeficiency virus (HIV) have been reported (2). Moreover, some case reports described untreated strongyloidiasis as cause of chronic inflammation and consequent LGL expansion (23). History of infection and serology for hepatitis and herpetic viruses and HIV have to be investigated when approaching patients with LGL expansion and lymphoproliferative disorders in general.…”

Section: Infectionsmentioning

confidence: 99%

Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds

et al. 2021

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Large granular lymphocytes (LGL) are lymphoid cells characterized by either a T-cell or a natural killer phenotype whose expansion may be reactive to toxic, infectious, and neoplastic conditions, or result from clonal selection. Recently, the higher attention to LGL clones led to their detection in many clinical conditions including myeloid neoplasms and bone marrow failures. In these contexts, it is still unclear whether LGL cells actively contribute to anti-stem cell autoimmunity or are only a reaction to dysplastic/leukemic myelopoiesis. Moreover, some evidence exists about a common clonal origin of LGL and myeloid clones, including the detection of STAT3 mutations, typical of LGL, in myeloid precursors from myelodysplastic patients. In this article we reviewed available literature regarding the association of LGL clones with myeloid neoplasms (myelodysplastic syndromes, myeloproliferative neoplasms, and acute myeloid leukemias) and bone marrow failures (aplastic anemia and pure red cell aplasia, PRCA) focusing on evidence of pathogenic, clinical, and prognostic relevance. It emerged that LGL clones may be found in up to one third of patients, particularly those with PRCA, and are associated with a more cytopenic phenotype and good response to immunosuppression. Pathogenically, LGL clones seem to expand after myeloid therapies, whilst immunosuppression leading to LGL depletion may favor leukemic escape and thus requires caution.

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Pulmonary strongyloidiasis associated CD3+ large granular lymphocytosis

Cited by 2 publications

References 11 publications

Hyperinfection with Strongyloides in a HIV-negative elderly male

Hyperinfection with Strongyloides in a HIV-negative elderly male

Large Granular Lymphocyte Expansion in Myeloid Diseases and Bone Marrow Failure Syndromes: Whoever Seeks Finds

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