Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia

Esquibies, A.E.; Zambrano, Eduardo; Ziai, James; Kesebir, Deniz; Touloukian, Robert J.; Egan, Marie E.; Reyes‐Múgica, Miguel; Bazzy‐Asaad, Alia

doi:10.1002/ppul.21148

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…Esquibies et al . recently reported a 19‐year‐old EA ± TEF patient who developed an esophageal‐to‐right upper lobe fistula and who had a squamous cell carcinoma of the trachea and sacrum …”

Section: Cancermentioning

confidence: 99%

Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update

Kovesi

2013

Dis Esophagus

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Despite early surgical repair, congenital esophageal atresia with or without tracheoesophageal fistula (EA ± TEF) has long-term effects on respiratory and gastrointestinal function. This review updates summarizes research published since 2003 on long-term respiratory complications in patients with a history of EA ± TEF. Pulmonary hypoplasia appears to not be rare in patients with EA ± TEF. Tracheomalacia is common and is associated with respiratory symptoms in childhood. Aspiration, associated with esophageal dysmotility and/or gastroesophageal reflux, may lead to reduced pulmonary function and bronchiectasis. Pulmonary function is generally normal, although lower than in control patients, and restrictive defects tend to be commoner than obstructive defects. Abnormal airway reactivity is common and, along with respiratory symptoms, is associated with atopy. However, the inflammatory profile in EA ± TEF patients based on bronchial biopsies and exhaled nitric oxide differs from typical allergic asthma. Recent studies suggest that in older patients, respiratory symptoms tend to be associated with atopy, but abnormal lung function tends to be associated with gastroesophageal reflux and with chest wall abnormalities. Early detection and management of aspiration may be important to help prevent decrements in pulmonary function and serious long-term complications in EA ± TEF patients.

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Section: Cancermentioning

confidence: 99%

Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update

Kovesi

2013

Dis Esophagus

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“…Close follow-up and periodic bronchoscopy should be initiated to screen these young patients if they present with persistent respiratory symptoms. [20] Some late-diagnosed malformations resulted in medically significant issues later in life, such as debilitating back pain related to vertebral anomalies, or unilateral renal agenesis with a dysplastic remaining kidney or the presence of a cardiac malformation necessitating careful follow-up of renal or cardiac function. [1] Patients considering VACTERL association undergo testing and/or examination for the presence of each of the core component features, with the following initial testing at a minimum: a thorough history and physical examination by a clinician familiar with the condition, X-rays of the entire spine with consideration of spinal MRI and/or ultrasound, echocardiogram, and renal ultrasound with blood and urine testing for renal function.…”

Section: Discussionmentioning

confidence: 99%

VACTERL association complicated with multiple airway abnormalities

Lin

Zhong

et al. 2019

Medicine

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Introduction:VACTERL association is an acronym that includes vertebral anomalies (V), anal atresia (A), cardiac defects (C), tracheoesophageal fistula (TEF) or esophageal atresia (EA), renal anomalies (R), and limb defects (L). Airway anomalies have rarely been reported with VACTERL association.Patient concerns:A 10-month-old boy who had been diagnosed with anal atresia and received surgical corrections soon after birth consulted our institution by complaining repeated cough and fever.Diagnosis:Diagnosis of VACTERL association was finally made. Bronchoscopy and chest CT with computed tomography angiography confirmed multiple airway abnormalities including bridging bronchus, airway malacia, and complete tracheal rings.Interventions:Supplemental oxygen was provided and antibiotics was initiated.Outcomes:The patient resolved gradually and was discharged 10 days later. The follow-up showed the patient has remained well just with mild psychomotor retardation.Conclusion:Multiple airway anomalies may be seen in VACTERL association. It is worthwhile to make special note for evaluating the tracheobronchial pulmonary system by chest CT and bronchoscopy, especially patients presenting with breathing anomalies.

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“…Interestingly, one adult case of pulmonary squamous cell carcinoma following repair of EA and tracheoesophageal fistula has been reported. 51 The tracheal tumor was associated with esophageal bronchial fistula originating from stenotic esophageal anastomosis.…”

Section: Esophageal Cancermentioning

confidence: 99%

Long-Term Outcome of Esophageal Anastomosis

Rintala

Pakarinen

2013

Eur J Pediatr Surg

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After repair of esophageal atresia (EA) in a newborn, esophageal dysmotility presenting as dysphagia and symptomatic gastroesophageal reflux are common. Significant esophageal morbidity associated with EA extends into adulthood. In adulthood approximately one-fifth of the patients have developed epithelial metaplastic changes, one-third of these have intestinal metaplasia (Barrett esophagus). Surgical complications, increasing age, and impaired esophageal motility predict the development of epithelial metaplasia after repair of EA. To date, worldwide, eight cases of esophageal cancer have been reported in young adults treated for EA. Incidence of esophageal cancer after EA repair is very much likely to increase in the future. Life-long endoscopic follow-up is warranted in patients with EA.

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Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia

Cited by 10 publications

References 8 publications

Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update

Long-term respiratory complications of congenital esophageal atresia with or without tracheoesophageal fistula: an update

VACTERL association complicated with multiple airway abnormalities

Long-Term Outcome of Esophageal Anastomosis

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