Pulmonary Sporotrichosis with Hyphae in a Human Immunodeficiency Virus–Infected Patient

Gori, S.; Lupetti, Antonella; Moscato, Giovanna; Parenti, Marco; Lofaro, A

doi:10.1159/000332549

Cited by 37 publications

(19 citation statements)

References 4 publications

(4 reference statements)

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“…Disseminated sporotrichosis cases have shown meningeal, respiratory, osteoarticular, lymphatic, and ocular involvement in both HIV-infected and non-HIV patients 14,[20][21][22][23] ; however, endocarditis involvement was not reported to date.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient

Silva‐Vergara

Camargo²,

Silva³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Disseminated sporotrichosis occurs in individuals with impaired cellular immunity, such as in cases of neoplasia, transplantation, diabetes, and especially, acquired immunodeficiency syndrome. This report presents a 32-year-old Brazilian human immunodeficiency virus (HIV)-infected patient who developed a protracted condition of disseminated sporotrichosis with endocarditis, bilateral endophthalmitis, and lymphatic involvement. He needed cardiac surgery to replace the mitral valve. Sporothrix brasiliensis isolates were recovered from cultures of subcutaneous nodules and mitral valve fragments. Species identification was based on classical and molecular methods. The patient received amphotericin B for 52 days and subsequently, oral itraconazole. He remains asymptomatic, and he is on maintenance therapy with itraconazole. Despite his positive clinical outcome, he developed bilateral blindness. To our knowledge, this case is the first report of endocarditis and endophthalmitis caused by S. brasiliensis.

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Section: Discussionmentioning

confidence: 99%

Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient

Silva‐Vergara

Camargo²,

Silva³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…The yeast phase of S. schenckii is the morphology present in lesions and is thought to disseminate in the systemic disease. However, mycelial elements have already been described in histopathological specimens of lung from sporotrichosis patients (22). Conidia are also thought to infect humans by inhalation (6).…”

Section: Discussionmentioning

confidence: 99%

Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins

Lima

Figueiredo²,

Pereira³

et al. 1999

Braz J Med Biol Res

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The pathogenic fungus Sporothrix schenckii is the causative agent of sporotrichosis. This subcutaneous mycosis may disseminate in immunocompromised individuals and also affect several internal organs and tissues, most commonly the bone, joints and lung. Since adhesion is the first step involved with the dissemination of pathogens in the host, we have studied the interaction between S. schenckii and several extracellular matrix (ECM) proteins. The binding of two morphological phases of S. schenckii, yeast cells and conidia, to immobilized type II collagen, laminin, fibronectin, fibrinogen and thrombospondin was investigated. Poly (2-hydroxyethyl methacrylate) (poly-HEMA) was used as the negative control. Cell adhesion was assessed by ELISA with a rabbit anti-S. schenckii antiserum. The results indicate that both morphological phases of this fungus can bind significantly to type II collagen, fibronectin and laminin in comparison to the binding observed with BSA (used as blocking agent). The adhesion rate observed with the ECM proteins (type II collagen, fibronectin and laminin) was statistically significant (P<0.05) when compared to the adhesion obtained with BSA. No significant binding of conidia was observed to either fibrinogen or thrombospondin, but yeast cells did bind to the fibrinogen. Our results indicate that S. schenckii can bind to fibronectin, laminin and type II collagen and also show differences in binding capacity according to the morphological form of the fungus.

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“…Incidentally, although the medical literature abounds in cases of sporotrichosis in various anatomic sites including lymphocutaneous forms, in the cytologic literature there are only cases of pulmonary sporothrichosis reported. 9,10,23 Hence, this is the first case of lymphocutaneous sporotrichosis that appears in the cytologic literature as diagnosed by FNA cytology.…”

Section: Discussionmentioning

confidence: 80%

Fine-needle aspiration cytologic diagnosis of lymphocutaneous sporotrichosis: A case report

Zaharopoulos¹

1999

Diagn. Cytopathol.

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Pulmonary Sporotrichosis with Hyphae in a Human Immunodeficiency Virus–Infected Patient

Cited by 37 publications

References 4 publications

Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient

Disseminated Sporothrix brasiliensis Infection with Endocardial and Ocular Involvement in an HIV-Infected Patient

Adhesion of the human pathogen Sporothrix schenckii to several extracellular matrix proteins

Fine-needle aspiration cytologic diagnosis of lymphocutaneous sporotrichosis: A case report

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