Pulmonary sequestration infected with nontuberculous mycobacteria: a report of two cases and literature review

Koh, Won Jung; Hong, Goohyeon; Kim, Kwhanmien; Ahn, Soomin; Han, Joungho

doi:10.1016/s1995-7645(12)60172-2

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…3A, B, and C). The SCID, nude, and GMCSF Ϫ/Ϫ mouse models with more than 1.0 ϫ 10 6 CFU in the lungs, spleens, and livers represent levels of bacteria present in an NTM-infected patient with cavitary disease (27). NTM patients generally have two types of pulmonary granulomas, nonnecrotizing and necrotizing (28,29).…”

Section: The Beige Nos2mentioning

confidence: 99%

Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models

Obregón-Henao

Arnett

Henao-Tamayo

et al. 2015

Antimicrob Agents Chemother

103

144

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bOver the last 10 years, Mycobacterium abscessus group strains have emerged as important human pathogens, which are associated with significantly higher fatality rates than any other rapidly growing mycobacteria. These opportunistic pathogens are widespread in the environment and can cause a wide range of clinical diseases, including skin, soft tissue, central nervous system, and disseminated infections; by far, the most difficult to treat is the pulmonary form. Infections with M. abscessus are often multidrug-resistant (MDR) and require prolonged treatment with various regimens and, many times, result in high mortality despite maximal therapy. We report here the evaluation of diverse mouse infection models for their ability to produce a progressive high level of infection with M. abscessus. The nude (nu/nu), SCID (severe combined immunodeficiency), gamma interferon knockout (GKO), and granulocyte-macrophage colony-stimulating factor (GMCSF) knockout mice fulfilled the criteria for an optimal model for compound screening. Thus, we set out to assess the antimycobacterial activity of clarithromycin, clofazimine, bedaquiline, and clofazimine-bedaquiline combinations against M. abscessus-infected GKO and SCID murine infection models. Treatment of GKO and SCID mice with a combination of clofazimine and bedaquiline was the most effective in decreasing the M. abscessus organ burden.

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Section: The Beige Nos2mentioning

confidence: 99%

Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models

Obregón-Henao

Arnett

Henao-Tamayo

et al. 2015

Antimicrob Agents Chemother

103

144

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“…Aspergillosis was reported at rates of 10–20% in some case series ( 14 , 15 ). Non-tuberculous mycobacterium (NTM) infection appears to be much rarer; few case reports have been published on NTM infection in PS ( 16 - 18 ). In the present study, some pathology reports revealed granulomas, but culturing of surgical specimens was not commonly done.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinical outcomes of pulmonary sequestration in adults between surgery and non-surgery groups

Song¹,

Park²,

Lee³

et al. 2022

J Thorac Dis

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Background: Pulmonary sequestration (PS) is a rare congenital lung malformation that can be incidentally diagnosed in adulthood. The natural course of PS in adults is scarcely known. Methods:In this retrospective cohort study, medical records and imaging results of adult patients diagnosed with PS between 1994 and 2019 were reviewed. Diagnoses of PS were confirmed by histopathological findings in resected cases, while non-resected cases were diagnosed based on the presence of anomalous systemic arterial supply and abnormal lung parenchyma on enhanced chest computed tomography (CT).Results: Among 104 patients with PS, the median age at diagnosis was 40.5 years, and 69 (66.3%) patients were asymptomatic. Patients in the surgery group were significantly younger (38.6 vs. 45.3 years, respectively, P=0.016), were more likely to be symptomatic initially (51.6% vs. 28.6%, respectively, P=0.015), and had larger PS (90.0 vs. 66.3 mm, respectively, P<0.001) than the non-surgery group. Of the patients in the surgery group, 29.0% (18/62) experienced postoperative complications. In the surgically resected cases, infections were only detected in intralobar PS, not in extralobar PS. Among 25 subjects without initial symptoms in the non-surgery group, 24 (96.0%) remained asymptomatic at the last follow-up.Conclusions: Adults with PS tended to undergo resection if they were young, symptomatic, and had large PS (a median diameter of 90.0 mm). Almost all subjects who were initially asymptomatic and did not undergo surgery remained asymptomatic at the last follow-up. Therefore, considering the indolent course of PS, initially asymptomatic adults with PS could be followed up without surgery.

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“…The association of pulmonary actinomycosis with BPS has not been well established, and only one case has been reported in the literature so far [ 14 ]; however, the identification of other microorganisms have been documented, the most prevalent being Aspergillus , Mycobacterium tuberculosis , nontuberculous mycobacteria, Pseudomonas and Nocardia [ 6 , 15 , 16 , 17 , 18 ]. Most patients with BPS and superinfection, such as in our case, are asymptomatic and have carried the congenital anomaly for years without diagnosis, being identified incidentally during a routine physical examination or by recurrent episodes of lung infection.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Sequestration Associated with Actinomycosis: A Case Report

et al. 2020

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Background: Bronchopulmonary sequestration is a rare congenital malformation of the lower respiratory tract; it consists of a nonfunctioning mass of lung tissue that is irrigated by an anomalous systemic artery. The association with Actinomyces superinfection has not been well established. Methods: We present the case of a 35-year-old woman with a history of recurrent episodes of pneumonia. Based on radiological and histopathological examination, she was diagnosed with intralobar bronchopulmonary sequestration associated with Actinomyces infection. Promoting clinical suspicion is essential to diagnose pulmonary actinomycosis in patients with recurrent pneumonia, to improve early recognition and timely management.

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Pulmonary sequestration infected with nontuberculous mycobacteria: a report of two cases and literature review

Cited by 8 publications

References 15 publications

Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models

Susceptibility of Mycobacterium abscessus to Antimycobacterial Drugs in Preclinical Models

Comparison of clinical outcomes of pulmonary sequestration in adults between surgery and non-surgery groups

Pulmonary Sequestration Associated with Actinomycosis: A Case Report

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