Pulmonary sequelae of treatment for breast cancer: a prospective study

Ooi, G. C.; Kwong, Dlw; Ho, J. C.; Lock, Derrick; Chan, F. L.; Lam, WK; Ngan, Hys; Au, Gordon K.H.; Tsang, KW

doi:10.1016/s0360-3016(01)01438-9

Cited by 40 publications

(51 citation statements)

References 30 publications

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“…Despite the decreased pulmonary function and the reduction of more than 20% of FVC and FEV1, the values remained within normality, according to weight, age and height of the studied sample 18,19 . Changes in lung capacity and volume are expected after RT 11,[21][22][23][24][25] , since there are potential risks of damaging the pulmonary parenchyma, losing type ii pneumocytes, losing surfactant and edema in the basement membrane 26 . But there is also the possibility that the patient can remain asymptomatic or never present any changes, be it in the parenchyma or in the pulmonary function, due to the "compensation in relation to the health lung", which did not receive radiation 24 .…”

Section: Discussionmentioning

confidence: 99%

“…Changes in lung capacity and volume are expected after RT 11,[21][22][23][24][25] , since there are potential risks of damaging the pulmonary parenchyma, losing type ii pneumocytes, losing surfactant and edema in the basement membrane 26 . But there is also the possibility that the patient can remain asymptomatic or never present any changes, be it in the parenchyma or in the pulmonary function, due to the "compensation in relation to the health lung", which did not receive radiation 24 . In the short term, the effects of RT did not cause an impact on the pulmonary function, even with the decrease of some spirometry and manovacuometry parameters, maybe because of the radiation dose, or the short follow-up time, or even because of the "compensation of the health lung".…”

Section: Discussionmentioning

confidence: 99%

“…RT: radiotherapy; FACT-F: Functional Assessment of Cancer Therapy Fatigue; FVC: forced vital capacity; FEV1: forced expiratory volume; PEF: peak expiratory flow; EPmax: maximal expiratory pressure; IPmax: maximal inspiratory pressure; r: Spearman's correlation with longer follow-up and higher number of reassessments after RT 4,5,[23][24][25] . Ooi et al 24 , in a prospective study performed 1, 3, 6 and 12 months after the conclusion of RT, showed that RT can be associated with an irreversible reduction of FCV, FEV1 and the carbon monoxide diffusing capacity.…”

Section: Discussionmentioning

confidence: 99%

“…Ooi et al 24 , in a prospective study performed 1, 3, 6 and 12 months after the conclusion of RT, showed that RT can be associated with an irreversible reduction of FCV, FEV1 and the carbon monoxide diffusing capacity.…”

Section: Discussionmentioning

confidence: 99%

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Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama

Santos¹,

Rett²,

Mendonça³

et al. 2013

Fisioter. Pesqui.

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O presente estudo comparou a função pulmonar e a fadiga de mulheres antes e após a radioterapia (RT) adjuvante para tratamento do câncer de mama, e correlacionou a função pulmonar com a dose de radiação e fadiga. Foi conduzido um estudo observacional longitudinal envolvendo 20 mulheres. A função pulmonar foi avaliada pela espirometria (ClementClarke®) e manovacuometria (GlobalMed®, modelo MVD 300), e a fadiga pelo Functional Assessment of Cancer Therapy Fatigue (FACT-F). Todas as avaliações foram realizadas antes da primeira sessão e uma semana após o término da RT adjuvante. Para a análise estatística foram utilizados os testes Wilcoxon Signed Rank Test e correlação de Spearman, adotando-se nível de significância p<0,05. Na espirometria, encontrou-se redução significativa da capacidade vital forçada (23,52%), do volume expiratório forçado no primeiro segundo (26,23%) e do pico de fluxo expiratório (10,12%) (p=0,001). As pressões expiratórias e inspiratórias máximas também diminuíram significativamente (25,45 e 32,92%, respectivamente). Observou-se diminuição significativa do bem-estar físico e do bem-estar funcional, e um aumento significativo da fadiga no FACT-F (p=0,001). Não foram observadas correlações entre as variáveis da função pulmonar com a dose de radiação e fadiga. Em curto prazo, a RT promoveu redução na função pulmonar, mas a mesma permaneceu próxima à normalidade para a amostra estudada. Observou-se aumento significativo da fadiga e diminuição dos escores dos domínios bem-estar físico e funcional.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Efeito da radioterapia na função pulmonar e na fadiga de mulheres em tratamento para o câncer de mama

Santos¹,

Rett²,

Mendonça³

et al. 2013

Fisioter. Pesqui.

View full text Add to dashboard Cite

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“…There are aspects of breast cancer treatment that result in altered cardiovascular and pulmonary function. Radiation therapy has been shown to have long-term effects on both the heart and lungs (80)(81)(82)(83)(84)(85). There is also strong evidence that commonly used chemotherapeutic agents are toxic for the heart and lungs as well (83,(86)(87)(88)(89).…”

Section: Physiologic Changesmentioning

confidence: 99%

The Intersection of Cancer and Aging: Establishing the Need for Breast Cancer Rehabilitation

Schmitz

Cappola

Stricker

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The increasing success of treatments for common cancers has resulted in growing awareness of the unique health care needs of cancer survivors. Cancer treatments can be toxic and have long-lasting effects on health, potentially accelerating the aging process and producing associated declines in physical function. In this synthesis of the literature, we critically examine the strength of existing evidence that breast cancer diagnosis and treatment are associated with a disproportionate decline in physical function compared with the effects of living without cancer for the same number of years. There is some observational epidemiologic evidence that women treated for breast cancer report greater declines in physical function than their peers. Discerning the factors associated with such declines and their clinical significance remains to be addressed. Physiologic, psychological, and behavioral changes associated with both aging and cancer treatment are reviewed. Parallels are proposed between existing preventive and rehabilitative programs and possibilities for similar interventions aimed at preventing, reversing, or halting declines in physical function in cancer survivors. Finally, a program of research is proposed to evaluate whether there is some subset of breast cancer survivors for whom prevention or rehabilitation of functional status declines is needed, as well as development of targeted, mechanistically driven interventions. (Cancer Epidemiol Biomarkers Prev 2007;16(5):866 -72)

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