Pulmonary Sequelae of Bronchopulmonary Dysplasia Survivors

Howling, S.J.; Northway, William H.; Hansell, David M.; Moss, Richard B.; Ward, Suzanne; Müller, Néstor L.

doi:10.2214/ajr.174.5.1741323

Cited by 85 publications

(58 citation statements)

References 11 publications

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“…The increase in sReff among children with prior BPD, but not in those without, may be associated with increased bronchial smooth muscle and airway narrowing associated with the more prolonged and intense ventilatory support received by these children [34]. These findings of functional impairments are consistent with morphometric data from survivors with BPD [35].…”

Section: Nature Of Underlying Pathophysiologysupporting

confidence: 75%

See 1 more Smart Citation

Nature and severity of lung function abnormalities in extremely pre-term children at 11 years of age

Lum¹,

Kirkby²,

Welsh³

et al. 2010

European Respiratory Journal

154

140

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Advances in neonatal care have resulted in increased survival of children born extremely pre-term (EP). Nevertheless the incidence of bronchopulmonary dysplasia and longterm respiratory morbidity remains high. We investigated the nature of pathophysiological changes at 11 yrs of age to ascertain whether respiratory morbidity in EP children primarily reflects alterations in the lung periphery or more centralised airway function in this population.Spirometry, plethysmography, diffusing capacity, exhaled nitric oxide, multiple-breath washout, skin tests and methacholine challenge were used during laboratory-based assessments in a subgroup of the 1995 EPICure cohort and in controls.Results were obtained in 49 EP and 52 control children. Lung function abnormalities were found in 78% of EP children, with evidence of airway obstruction, ventilation inhomogeneity, gas trapping and airway hyperresponsiveness. Levels of atopy and exhaled nitric oxide were similar between the groups. Prior wheeze was associated with significant reductions in forced flows and volumes. By contrast, abnormalities of the lung periphery appear to be mediated primarily through EP birth per se.The prevalence of lung function abnormalities, which is largely obstructive in nature and likely to have long-term implications, remains high among 11-yr-old children born EP. Spirometry proved an effective means of detecting these persistent abnormalities.

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Section: Nature Of Underlying Pathophysiologysupporting

confidence: 75%

“…*: p,0.05; **: p,0.01; ***: p,0.0001. in persons with cystic fibrosis [30] it has not been found to be particularly discriminative when assessing BPD or prematurity either during infancy [31,35] or in the current study.…”

Section: Nature Of Underlying Pathophysiologycontrasting

confidence: 71%

Nature and severity of lung function abnormalities in extremely pre-term children at 11 years of age

Lum¹,

Kirkby²,

Welsh³

et al. 2010

European Respiratory Journal

154

140

View full text Add to dashboard Cite

show abstract

“…However, despite that, there is still a lack information in regards to structural abnormalities in ex-preterm children and adults with and without BPD (See Table 4). High resolution computed tomography (HRCT) images of the chest have been reported to be abnormal and thus useful in the diagnosis of BPD (Howling et al, 2000;Oppenheim et al, 1994). In one cohort of children with a median age of 10 years, 20/26 (77%) of the subjects had reduced lung attenuation (Aquino et al, 1999).…”

Section: Structural Lung Diseasementioning

confidence: 99%

Preterm Birth and Long-Term Pulmonary Function

Narang¹,

Al-Naimi²

2012

Preterm Birth - Mother and Child

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“…By contrast, Northway and associatcs continued after 1967 to call attention to and to make fbrther observations on the interstitial component of longer term sequelae of pressure based ventilatory support and oxygen enrichment (Northway and Rosan, 1968;Northway and Rosan, 1969;Bonikos et al, 1976;Edwards et al, 1977;Northway, 1979;Northway, 1990;Northway et al, 1990;Northway, 1992;Howling et al, 2000). An early study of thc long tcrm radiographic findings dates from 1968.…”

mentioning

confidence: 99%

“…(Shepard et al, 1968). Improvements in neonatal treatment since then have engendered rnore detailed studies of the progressive lung lesions identified in infants four to ten months old (Erickson et al, 1987) and young adult survivors (Howling et al, 2000).…”

mentioning

confidence: 99%