Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature

Lim, Jung Hwan; Lee, Nuri; Choi, Dae‐Woong; Oh, Hyung-Hoon; Park, Ha Young; Kim, Ki‐Hyun; Kim, Tae‐Ok; Park, Cheol‐Kyu; Shin, H J; Choi, Yoo‐Duk; Yun, Ju Sik; Song, Sang‐Yun; Oh, Il‐Seok

doi:10.1111/1759-7714.12341

Cited by 21 publications

(25 citation statements)

References 13 publications

(17 reference statements)

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“…PSP is more common in East Asian populations and is rare among Western populations (7). In this study, PSP was more common in women who were non-smokers (88.2%), which is consistent with previous reports (8), and PSP was found to occur often in the 40-70-year age group. In contrast, lung cancer was more common in men (69.0%) and was often found in the 60-70-year age group; moreover, most patients were smokers.…”

Section: Discussionsupporting

confidence: 92%

Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer

Zhu

2017

J. Thorac. Dis.

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Background: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign lung tumor. This study investigated the diagnostic experience of PSP and lung cancer. Methods: This study is a retrospective study. We observed the locations of lung lesions, imaging form and clinical symptoms, and recorded the surgical complications through comparing patients with PSP and lung cancer. PSP was commonly found in women (88.2%), often occurred in the left lower lobe (32.6%), and was associated with a lesion size of 10-20 mm (48.7%). PSP patients presented with cough, sputum, chest pain, and most patients had a single lesion, which could showed no clear boundary. Most PSP patients exhibited no enlargement of mediastinal lymph nodes, had no involvement of the blood vessels, and had low computed tomography (CT) values (low Hounsfield units). Lung cancers were more commonly found in men (69.0%), with the lesions scattered throughout all lobes of the lung. Cases with a tumor size >30 mm accounted for 76.2% of patients. Lung cancer patients also presented systemic symptoms, and the tumors were found to have unclear boundaries. Moreover, patients presented with enlarged mediastinal lymph nodes, high CT values, and heterogeneous internal tumor texture. Conclusions: This study showed that PSP was rare and difficult to differentiate from lung cancer. PSP was often found in 40-70-year-old non-smoking women and most patients presented with cough and sputum.Patients often had a single lesion, which was commonly located in the left lower lobe and could have unclear boundaries. The majority of patients exhibited no enlargement of mediastinal lymph nodes and had low CT values. Therefore, our results can provide some basis for the differential diagnosis of PSP and lung cancer.

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Section: Discussionsupporting

confidence: 92%

Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer

Zhu

2017

J. Thorac. Dis.

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“…After immunohistochemical and ultrastructural studies were performed, the thinking has become that the neoplasm originates from a proliferation of type 2 alveolar pneumocytes and multipotential primitive respiratory epithelium and is not a vascular tumor. 2,3 The name was subsequently changed to pulmonary pneumocytoma and became known as an adenoma in the 2015 World Health Organization classification, whereas it was referred to as a miscellaneous tumor in the 1999 and 2004 editions. 4 Although there is a paucity of literature on predisposing factors, the neoplasm presents most commonly in middle-aged Asian women in a distribution that is fivefold more than men (Table 1).…”

Section: Clinical Discussionmentioning

confidence: 99%

“…4 Although there is a paucity of literature on predisposing factors, the neoplasm presents most commonly in middle-aged Asian women in a distribution that is fivefold more than men (Table 1). 3 The tumor most often presents incidentally while the patient is asymptomatic and is discovered as a pulmonary nodule, or in some cases multiple pulmonary nodules, on chest radiography. It is often chronic in nature and symptoms, if present, are often nonspecific.…”

Section: Clinical Discussionmentioning

confidence: 99%

A 58-Year-Old Woman With Back Pain and an Unusual Diagnosis

Bohm

Asiry

Hasanovic

et al. 2019

Chest

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A 58-year-old postmenopausal woman presented to her primary care physician with lower back pain. She denied respiratory symptoms. Her medical history is significant for hypertension, hyperlipidemia, and prediabetes. Her surgical history consists of a tonsillectomy and a remote dilatation and curettage procedure. She denied a history of smoking, alcohol use, or recreational drug use. A review of systems was otherwise negative.

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“…Accordingly, the terminology of “sclerosing pneumocytoma” has been adopted in the recent WHO classification of lung tumors . In imaging analyses, SP may resemble lung cancer, metastatic cancer, pulmonary hamartoma or even tuberculosis . SP usually shows the hypometabolic lesion on the fluorodeoxyglucose positron emission tomography/computed tomography (PET‐CT), but some cases with SP may show the uptake in PET‐CT .…”

Section: Discussionmentioning

confidence: 99%

“…17 In imaging analyses, SP may resemble lung cancer, metastatic cancer, pulmonary hamartoma or even tuberculosis. [18][19][20] SP usually shows the hypometabolic lesion on the fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT), but some cases with SP may show the uptake in PET-CT. 9,18,21 SP usually occurs as a solitary mass, but some cases may arise multiply. 21,22 Most SPs show neither recurrence nor metastasis, but some case with lymph node metastasis have been reported previously.…”

Section: Discussionmentioning

confidence: 99%

Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma

Ohara

Mizuno

Yorita

2016

Diagnostic Cytopathology

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To the best of our knowledge, there is no description on immunocytochemical study of sclerosing pneumocytoma (SP) using a cell transfer method. In this article, we report imprint cytological and immunocytochemical findings of SP. Three cases of SP possessing both imprint cytological and histological materials were examined. All tumors showed well-defined margin grossly. On microscopic examination, the tumor consisted of surface and stromal round cells. Cytologically, surface and stromal round cells showed fragments or clusters of papillary configuration with low N/C ratio and cell clusters of small to medium-sized cells with high N/C ration. Immunocytochemically, surface cells showed the positive reaction for surfactant apoprotein A (SPA), but stromal round cell exhibited the negative reaction for SPA. Cytologists and pathologists should steadily recognize cytological findings of surface and stromal round cells of SP. Immunocytochemistry of SPA may be useful in the discrimination of both cells. Diagn. Cytopathol. 2017;45:274-278. © 2016 Wiley Periodicals, Inc.

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Pulmonary sclerosing pneumocytoma mimicking lung cancer: Case report and review of the literature

Cited by 21 publications

References 13 publications

Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer

Analysis of the clinical differentiation of pulmonary sclerosing pneumocytoma and lung cancer

A 58-Year-Old Woman With Back Pain and an Unusual Diagnosis

Imprint cytologic and immunocytochemical findings of sclerosing pneumocytoma

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