Pulmonary sclerosing pneumocytoma masquerading adenocarcinoma with co-existing BRAF V600E and PTEN mutation

Dantis, Klein; Gupta, Ashish Kumar; Kashyap, Nitin; Kashyap, Yashwant; Ranganath, T G; Pati, Sanghamitra; Kumar, Mayank; Thakur, Shiva; Ravina, Mudalsha

doi:10.1016/j.ctarc.2021.100429

Cited by 7 publications

(9 citation statements)

References 14 publications

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“…This case indicated that pulmonary sclerosing pneumocytoma was not self-limiting despite its benign nature. Some pulmonary sclerosing pneumocytoma cases have been reported with multiple lung involvement [ 39 ], lymph node metastasis [ 8 , 11 , 16 ], and distant metastasis [ 40 ]. Those elucidated the potential malignant nature of pulmonary sclerosing pneumocytoma.…”

Section: Discussionmentioning

confidence: 99%

“…Those elucidated the potential malignant nature of pulmonary sclerosing pneumocytoma. There were theories that lymph node metastasis of pulmonary sclerosing pneumocytoma was mediated through air space pattern [ 11 ]. Dantis and colleagues [ 11 ] reported that PET scan could help guide lymph node dissection, since the cases with SUV max uptake of more than 2.5 mostly had positive mediastinal lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…There were theories that lymph node metastasis of pulmonary sclerosing pneumocytoma was mediated through air space pattern [ 11 ]. Dantis and colleagues [ 11 ] reported that PET scan could help guide lymph node dissection, since the cases with SUV max uptake of more than 2.5 mostly had positive mediastinal lymph node metastasis. Wei and colleagues [ 4 ] reported a pulmonary sclerosing pneumocytoma case with local recurrence 10 years after initial wedge resection.…”

Section: Discussionmentioning

confidence: 99%

“…The molecular alterations in the sclerosing pneumocytoma were one of the study focuses and showed diagnostic value. AKT1 mutation was the most commonly reported gene mutation and was speculated to be the genetic hallmark of sclerosing pneumocytoma [ 11 , 41 , 42 ]. AKT1 mutation might induce cells proliferation and morphology changing, but would not induce progress to malignancy [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to the WHO categorization of lung and pleural tumors (2018, ICD-11 for Mortality and Morbidity Statistics), pulmonary sclerosing pneumocytoma was categorized as benign, fibromatous neoplasms [ 6 ]. Nevertheless, there have been several reports on the possible malignant characteristics with lymph node metastasis [ 7 – 11 ] or local recurrence [ 12 ]. Although the prognosis of pulmonary sclerosing pneumocytoma seems not to be affected by these malignant potentials, there are other factors which may be related to the prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary sclerosing pneumocytoma: clinical features and prognosis

Zheng

Zhou

et al. 2022

World J Surg Onc

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Background Pulmonary sclerosing pneumocytoma is a kind of rare benign pulmonary tumor with potential malignancy. The clinical features, risk factors for prognosis, and optimal treatment have not been identified yet. This study aimed to investigate the clinical features and prognosis of pulmonary sclerosing pneumocytoma. Methods We retrospectively performed a review of pulmonary sclerosing pneumocytoma patients in West China Hospital from 2009 to 2019. The basic characteristics, treatment regimens, operation detail, postoperative variables, and follow-up time were recorded for each case. Differences in features between patients undergoing lobectomy and segmentectomy were compared. We also performed a case review and summarized reported clinical features in former studies. Results Altogether 61 pulmonary sclerosing pneumocytoma patients were retrospectively reviewed. Fifty-six patients were female and 5 were male. The patients’ median age was 51 (23-73). Seven (11.48%) patients had smoking history. Twenty tumors were located in the right lung [upper lobe (n = 7), middle (n = 2), and lower (n = 11)] and 41 in the left [upper (n = 12) and lower (n = 29)]. The median tumor size was 2 (0.9-7) cm. Thirty-six (59.02%) patients underwent sublobectomy (segmentectomy or wedge resection) whereas 25 (40.98%) underwent lobectomy. All patients recovered uneventfully, and no perioperative mortality was identified. Sublobectomy showed a trend towards reduced chest tube duration and shorter postoperative hospital stays compared with lobectomy. Conclusions The findings showed good prognosis of pulmonary sclerosing pneumocytoma and proved its benign characteristics. Sublobectomy showed advanced efficacy regarding chest tube duration and postoperative hospital stay compared with lobectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pulmonary sclerosing pneumocytoma: clinical features and prognosis

Zheng

Zhou

et al. 2022

World J Surg Onc

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Pulmonary Sclerosing Pneumocytoma

Zhang

2023

Diagnostic Imaging of Lung Cancers

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What's new in benign lung tumours?

Boland

2023

Histopathology

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While lung cancer is one of the most common malignancies routinely encountered by pathologists, benign pulmonary neoplasms are quite rare. However, it is important for pathologists to be familiar with the typical diagnostic features of benign lung tumors to avoid confusing them with malignant morphological mimics. There have also been intriguing discoveries in the genetics of benign pulmonary neoplasms in the past decade. This review will cover several of the most common benign lung tumors, including the diagnostic categories of pulmonary adenomas, bronchial papillomas, and benign mesenchymal tumors, with discussion of the current classification, differential diagnosis, and current knowledge regarding genetic drivers.

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Pulmonary sclerosing pneumocytoma masquerading adenocarcinoma with co-existing BRAF V600E and PTEN mutation

Cited by 7 publications

References 14 publications

Pulmonary sclerosing pneumocytoma: clinical features and prognosis

Pulmonary sclerosing pneumocytoma: clinical features and prognosis

Pulmonary Sclerosing Pneumocytoma

What's new in benign lung tumours?

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