Pulmonary sclerosing hemangioma with a rare symptom: A case report and review of the literature

Abstract

Abstract. Pulmonary sclerosing hemangioma (PSH) is a relatively rare benign tumor. However, as it occurs only rarely, the natural course of the tumor is not well understood. In the present study, a case is presented of a 35-year-old woman who underwent intermittent fevers for more than one year. This case highlighted fever as a rare symptom of PSH. Fever is possibly one of the symptoms of PSH, although it is less likely to occur. Another symptom of the patient was that the tumor grew quickly in two months. The lesion was diagnosed as multiple sclerosing hemangioma of the lung (i.e., PSH), in which papillary, solid and sclerotic patterns appeared. Immunohistochemical evaluation of the lesion revealed positive staining for thyroid transcription factor 1 (TTF1), epithelial membrane antigen (EMA), pancytokeratin (PCK) and cytoskeleton 7 (CK7). In the present case study, the biological activity of PSH was identified to be aggressive. A review of the literature was performed in order to comment further on the clinical and pathological features of this rare disease.

Ectopic ACTH Syndrome With Association of Multiple Pulmonary Sclerosing Pneumocytomas and Multiple Carcinoid Tumorlets

“…Microscopically, it is mainly composed of cuboidal surface cells that tend to differentiate into type II pneumocytes and polygonal stromal cells, which have multiple differentiation potentials [1]. It is histologically characterized by the presence of hemorrhagic, papillary, solid, or sclerotic areas [2]. In our case, histological diagnosis showed multiple SPs with pneumocyte hyperplasia, and multiple carcinoid tumorlets within the tumor that expressed ACTH.…”

“…The etiology is not well understood. Most patients are asymptomatic at diagnosis and the tumor is found incidentally on screening chest radiographs [2]. Thoracotomy is indicated for a definite diagnosis, and surgical resection can be curative [3].…”

A female with solitary fibrous tumor pleura mimicking pulmonary sclerosing pneumocytoma in low resource setting: A case report

“…The IHC test in SFTP included a primary positive CD34 result, followed by CD99, cytokeratin (S100), and epithelial membrane antigen (EMA) [10] . CD34 is the most frequently used biomarker for SFTP, which in PSP patients the IHC examination was seen for TTF-1, EMA, and pan-cytokeratin immunostaining [11] , [12] , [13] .…”

“…In cases of SFTP, surgery is the preferred action which in cases of malignancy can be surgical procedures performed safely without a preoperative diagnosis [11] . The surgical procedure chosen was thoracotomy with an intercostal incision which is a surgical technique that is effectively removing the giant tumor in the lung [14] .…”

Sclerosing pneumocytoma in a 1-year-old girl presenting with massive hemoptysis: A case report

“…But here we report a one-year-old girl with SP. Most of the SP patients are clinically asymptomatic, but fever had been mentioned previously in the literature as a rare predominant symptom [ 7 ]. For our patient, hemoptysis was the main symptom.…”