Pulmonary Sarcoidosis: Pathogenesis, Staging and Therapy

Saltini, Cesare; Crystal, Ronald G.

doi:10.1159/000233739

Cited by 8 publications

(3 citation statements)

References 24 publications

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“…Sarcoidosis is an inflammatory systemic disease characterized by noncaseating granulomas composed of epithelioid giant cells, macrophages, and lymphocytes5.…”

Section: Discussionmentioning

confidence: 99%

Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report

et al. 2013

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Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma. However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma.

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“…Sarcoidosis is an inflammatory systemic disease characterized by noncaseating granulomas composed of epithelioid giant cells, macrophages, and lymphocytes5.…”

Section: Discussionmentioning

confidence: 99%

Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report

et al. 2013

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“…In patients with sarcoid, lymphocytes represent 50 to 60% of all cells recovered from a patient with active disease, and 95% are T lymphocytes. 60 Alveolar macrophages are also increased in patients with sarcoid.…”

Section: Disease Activitymentioning

confidence: 99%

Pulmonary Sarcoidosis

Chiles¹,

Putman²

1992

Semin Respir Crit Care Med

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“…Sarcoidosis (syn. M. Boeck, M. Besnier‐Boeck‐Schaumann) is an inflammatory systemic disease characterized by noncaseating granulomas composed of epitheloid giant cells, macrophages, and lymphocytes 1, 2. Although the etiology of sarcoidosis remains unclear, several studies suggest an interaction of genetic predisposition and triggering substances.…”

Section: Introductionmentioning

confidence: 99%