Pulmonary response to kaolin, mica and talc in mice

Sahu, A.P.; Shanker, Ravi; Zaidi, S. H.

doi:10.1016/s0014-4908(78)80031-3

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…The lymph nodes showed thick reticulin fibers. These results are supported by those of Sahu et al (46).…”

Section: Intratracheal Instillationsupporting

confidence: 89%

“…They did not find any progression of the collagen formation at 12 months. Sahu et al (46) found no progression of reticulin fiber formation between 150 and 210 d. This result was also observed by King et al (27); however, mica treated with hydrochloric acid induced a nodular reaction within five weeks with increasing reticulin formation up to 15 months later.…”

Section: Intratracheal Instillationsupporting

confidence: 57%

“…Dianova et al (14) concluded that resin reduced the fibrogenic effect of mica. (46) reported an additional proliferation of fibroblasts and reticulin fibers. In this period proliferation of fibroblasts and reticulin fibers was also reported by King et al (27).…”

Section: General Surveymentioning

confidence: 99%

“…In older studies rabbits, dogs, rats, and guinea pigs were used, whereas more recent studies have used various breeds of rats . It is difficult to induce fibrosis in the lungs of mice by silica and mica (46).…”

Section: General Surveymentioning

confidence: 99%

“…Transportation of mica particles to the tracheobronchial lymph nodes (26,46,55) is one of the mechanisms which slowly reduces the concentration of mica in the lungs. Le Bouffant et al (32), Sahu et al (46), and Shanker et al (50) found no progression of collagen and/or reticulin formation between 6 and 12 months after exposure.…”

Section: Experimental Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Mica pneumoconiosis--a literature review.

Skulberg¹,

Gylseth²,

Skaug³

et al. 1985

Scand J Work Environ Health

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This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/3890162 Scand J Work Environ Health 11 (1985) 11 (1985) 65-74. Sixty-six cases of mica pneumoconiosis have been reported in the literature. Twenty-six of the cases suggest that pneumoconiosis may be caused by pure mica alone. In only six cases the diagnosis was based on clinical examination, radiography, and lung biopsy or autopsy results. In one of these six, doubt was raised by the authors about the purity of the mica exposure. Seven epidemiologic studieshave been performed among mica-processing workers, and these studies are all cross-sectional. In addition 30 experimental investigations have been carried out. However, there are no controlled inhalation studies among them. The results from the intratracheal instillation studies do not give a unanimous conclusion as to whether pure mica is fibrogenic or not. Present knowledge suggests that pure mica is moderately toxic and may induce pneumoconiosis. Exposure to mica is usually associated with exposure to other minerals such as quartz and feldspar. REVIEWS

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“…The lymph nodes showed thick reticulin fibers. These results are supported by those of Sahu et al (46).…”

Section: Intratracheal Instillationsupporting

confidence: 89%

Section: Intratracheal Instillationsupporting

confidence: 57%

Section: General Surveymentioning

confidence: 99%

Section: General Surveymentioning

confidence: 99%

Section: Experimental Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Mica pneumoconiosis--a literature review.

Skulberg¹,

Gylseth²,

Skaug³

et al. 1985

Scand J Work Environ Health

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A critical review of talc and ovarian cancer

Goodman

Kerper

Prueitt

et al. 2020

Journal of Toxicology and Environmental Health, Part B

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The importance of mineralogical composition for the cytotoxic and pro-inflammatory effects of mineral dust

et al. 2022

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Background Respirable mineral particles represent a potential health hazard in occupational settings and ambient air. Previous studies show that mineral particles may induce cytotoxicity and inflammatory reactions in vitro and in vivo and that the potency varies between samples of different composition. However, the reason for these differences is largely unknown and the impact of mineralogical composition on the biological effects of mineral dust remains to be determined. Methods We have assessed the cytotoxic and pro-inflammatory effects of ten mineral particle samples of different composition in human bronchial epithelial cells (HBEC3-KT) and THP-1-derived macrophages, as well as their membranolytic properties in erythrocytes. Moreover, the results were compiled with the results of recently published experiments on the effects of stone particle exposure and analysed using linear regression models to elucidate which mineral components contribute most to the toxicity of mineral dust. Results While all mineral particle samples were more cytotoxic to HBEC3-KT cells than THP-1 macrophages, biotite and quartz were among the most cytotoxic in both cell models. In HBEC3-KT cells, biotite and quartz also appeared to be the most potent inducers of pro-inflammatory cytokines, while the quartz, Ca-feldspar, Na-feldspar and biotite samples were the most potent in THP-1 macrophages. All particle samples except quartz induced low levels of membranolysis. The regression analyses revealed associations between particle bioactivity and the content of quartz, muscovite, plagioclase, biotite, anorthite, albite, microcline, calcite, chlorite, orthopyroxene, actinolite and epidote, depending on the cell model and endpoint. However, muscovite was the only mineral consistently associated with increased cytotoxicity and cytokine release in both cell models. Conclusions The present study provides further evidence that mineral particles may induce cytotoxicity and inflammation in cells of the human airways and that particle samples of different mineralogical composition differ in potency. The results show that quartz, while being among the most potent samples, does not fully predict the toxicity of mineral dust, highlighting the importance of other particle constituents. Moreover, the results indicate that the phyllosilicates muscovite and biotite may be more potent than other minerals assessed in the study, suggesting that this group of sheet-like minerals may warrant further attention.

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Pulmonary response to kaolin, mica and talc in mice

Cited by 6 publications

References 12 publications

Mica pneumoconiosis--a literature review.

Mica pneumoconiosis--a literature review.

A critical review of talc and ovarian cancer

The importance of mineralogical composition for the cytotoxic and pro-inflammatory effects of mineral dust

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