Pulmonary Resection After Successful Downstaging with Photodynamic Therapy

Mortman, Keith D.; Frankel, Kenneth M.

doi:10.1016/j.athoracsur.2005.12.007

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…To the best of ourknowledge, just one case is reported in recent literature, where successful downstaging of an obstructing endobronchial NSCLC after PDT could be achieved enabling complete resection [49].…”

Section: Discussionmentioning

confidence: 97%

The clinical impact of photodynamic therapy in thoracic surgery

et al. 2010

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Zusammenfassung. Grundlagen: Die Prognose von Patienten mit malignem Pleuramesotheliom, inoperablem fortgeschrittenen Ö sophagus-oder Bronchuskarzinom ist nach wie vor sehr trist. Die photodyname Therapie (PDT) stellt eine sehr wirkungsvolle Option in der Palliativtherapie dieser Malignome dar.Methodik: Die Funktionsweise der PDT beruht auf der Illuminierung von Malignomen nach vorangegangener intravenöser Photosensibilisierung und konsekutiver selektiver Tumorzellnekrose. Im Falle des Ö sophaguskarzinoms als auch der malignen Bronchusstenose wird die PDT endoskopisch durchgefü hrt, beim malignen Pleuramesotheliom geschieht dies intraoperativ im Anschluss an die Dekortikation.Ergebnisse: Mit Hilfe der PDT wird eine signifikante Reduktion der endoluminalen bzw. intrakavitären Tumormasse, verbunden mit deutlich verbesserter Lebensqualität und verlängertem rezidiv-freiem Intervall, erreicht. Außerdem kann der Patient dadurch fü r weitere palliative Therapiemaßnahmen konditioniert werden.Schlussfolgerungen: Die PDT stellt eine sichere, gut durchfü hrbare und äußerst wirksame Option in der endoskopischen Palliativtherapie des fortgeschrittenen Ö sophagus-als auch des Bronchuskarzinoms dar. Ü berdies kann die PDT als supportive Maßnahme in der chirurgischen Therapie des malignen Pleuramesothelioms eingesetzt werden.Schlüsselwörter: Ö sophaguskarzinom, Bronchuskarzinom, malignes Pleuramesotheliom, photodyname Therapie, palliative Therapie.Summary. Background: Patients suffering from malignant pleural mesothelioma, advanced esophageal cancer or progressive lung cancer, ineligible for resection, still have a poor prognosis. Photodynamic Therapy (PDT) is a very effective approach in the palliative treatment regimen of these malignancies.Methods: The mechanism of function is based on the illumination of malignant tissue after selective accumulation of photosensitizers in tumor cells resulting in local tumor necrosis. In case of esophageal cancer and malignant bronchogenic stenosis, PDT is performed endoscopically whereas in malignant pleural mesothelioma intra-cavitary PDT is done after decortication.Results: Significant reduction of the endoluminal/ intrathoracic tumor associated with increased quality of life and prolonged disease-free survival can be achieved which helps conditioning the patient for further palliative treatment procedures.Conclusions: PDT has become a safe, feasible, and efficient approach in the endoscopic palliation of advanced esophageal cancer, malignant tracheo-bronchial stenosis as well as a supportive treatment option in the surgical management of malignant pleural mesothelioma.

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Section: Discussionmentioning

confidence: 97%

The clinical impact of photodynamic therapy in thoracic surgery

et al. 2010

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“…15,16 Despite ongoing research efforts, photosensitizers (PSs) that can be applied in this practice are rare. 17,18 This may be attributed to the following factors. First, the vast majority of reported PSs function primarily via the type II pathway to generate ROS; their inhibition efficacy is impeded by intratumoral O 2 deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Imaging-guided photodynamic therapy (PDT), a highly promising antineoplastic technique, has garnered considerable attention owing to its integrated merits of light-triggered real-time noninvasive diagnosis and simultaneous in situ therapy. − It could serve as a promising alternative to other intervention therapies. Cytotoxic reactive oxygen species (ROS) can be utilized to downstage tumor, while fluorescence with high spatiotemporal resolution and sensitivity can be used for follow-on surgical navigation. , Despite ongoing research efforts, photosensitizers (PSs) that can be applied in this practice are rare. , This may be attributed to the following factors. First, the vast majority of reported PSs function primarily via the type II pathway to generate ROS; their inhibition efficacy is impeded by intratumoral O 2 deficiency. , Second, achieving the ideal balance between ROS generation and fluorescence emission demands intricate manipulation.…”

Section: Introductionmentioning

confidence: 99%

“Two-Stage Rocket-Propelled” Strategy Boosting Theranostic Efficacy with Mitochondria-Specific Type I–II Photosensitizers

Yang,

Zhang,

Yang

et al. 2024

ACS Appl. Mater. Interfaces

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Imaging-guided photodynamic therapy (PDT) holds great potential for tumor therapy. However, achieving the synergistic enhancement of the reactive oxygen species (ROS) generation efficiency and fluorescence emission of photosensitizers (PSs) remains a challenge, resulting in suboptimal image guidance and theranostic efficacy. The hypoxic tumor microenvironment also hinders the efficacy of PDT. Herein, we propose a "two-stage rocketpropelled" photosensitive system for tumor cell ablation. This system utilizes MitoS, a mitochondria-targeted PS, to ablate tumor cells. Importantly, MitoS can react with HClO to generate a more efficient PS, MitoSO, with a significantly improved fluorescence quantum yield. Both MitoS and MitoSO exhibit less O 2 -dependent type I ROS generation capability, inducing apoptosis and ferroptosis. In vivo PDT results confirm that this mitochondrial-specific type I−II cascade phototherapeutic strategy is a potent intervention for tumor downstaging. This study not only sheds light on the correlation between the PS structure and the ROS generation pathway but also proposes a novel and effective strategy for tumor downstaging intervention.

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PDT-Lung

Allison¹

2011

Medical Radiology

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Pulmonary Resection After Successful Downstaging with Photodynamic Therapy

Cited by 8 publications

References 6 publications

The clinical impact of photodynamic therapy in thoracic surgery

The clinical impact of photodynamic therapy in thoracic surgery

“Two-Stage Rocket-Propelled” Strategy Boosting Theranostic Efficacy with Mitochondria-Specific Type I–II Photosensitizers

PDT-Lung

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