Pulmonary rehabilitation and BDNF levels in patients with chronic obstructive pulmonary disease: A pilot study

Araújo, Cintia Laura Pereira de; Silva, Ivy Reichert Vital da; Reinaldo, Gustavo Pereira; Peccin, Pâmela Krause; Pochmann, Daniela; Teixeira, Paulo José Zimermann; Elsner, Viviane Rostirola; Lago, Pedro Dal

doi:10.1016/j.resp.2018.07.011

Cited by 3 publications

(2 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…56 57 Moreover, it has been shown that the plasma of patients with COPD often contains abnormal levels of inflammatory mediators, including IL-6, IL-8, CRP, TNF-α and BDNF. [58][59][60] Therefore, in this study, we seek to observe whether PR can affect GMV and blood inflammatory mediators and to explore the possible mechanism by which exercise affects cognitive function in patients with COPD. TCEs are moderate-intensity mind-body exercises that coordinate bodily movement, breathing, posture and attention.…”

Section: Discussionmentioning

confidence: 99%

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Duan

Wang

et al. 2020

BMJ Open

View full text Add to dashboard Cite

IntroductionCognitive impairment, an important complication in patients with chronic obstructive pulmonary disease (COPD), seriously affects self-management of the disease and quality of life (QoL). As an exercise-based intervention programme, pulmonary rehabilitation (PR)—especially aerobic exercise (mainly mind–body exercise) and resistance exercise (RE)—has been proposed for its potential effectiveness in improving cognitive function. However, there is still a lack of strong evidence for PR’s effectiveness. In this study, we expect to clarify the effects of pulmonary-based Qigong exercise and elastic band-based RE on cognitive function in patients with COPD and to fill in the relevant evidence blanks.Methods and analysisThis study is a single-centre randomised controlled trial with assessor and data analyst blinding. We will recruit 108 participants with stable COPD starting on 23 December 2019, and randomly allocate them into the pulmonary-based Qigong exercise group, elastic band-based RE group, pulmonary-based Qigong exercise and elastic band-based RE combined group, or control group at a 1:1:1:1 ratio. Participants in intervention groups will perform 30 min of exercise two times per day, 5 days a week, for 12 weeks. The primary outcome will be the global cognitive function as assessed by the Montreal Cognitive Assessment and auditory event-related potential P300. Secondary outcomes will include the specific cognitive domains—attention, memory, executive function, verbal fluency and mental-processing speed; psychological functions and QoL. Exploratory outcomes will include grey matter volume and levels of inflammatory mediators. Outcomes will be measured before and after the interventions.Ethics and disseminationEthics approval has been granted by the Ethics Committee of Yue-Yang Integrative Medicine Hospital, an affiliate of Shanghai University of Traditional Chinese Medicine, Shanghai, China (Grant No. 2019-141). Written informed consent will be obtained from each participant before any procedures are performed. The findings will be published in peer-reviewed journals and presented at academic conferences.Trial registration numberChiCTR1900026869; pre-results.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Duan

Wang

et al. 2020

BMJ Open

View full text Add to dashboard Cite

show abstract

“…Importantly, BDNF can cross the blood-brain barrier in a bidirectional manner, as well it was also reported that the peripheral levels of this neurotrophin seem to present a strong correlation with cerebrospinal fluid levels [8]. Therefore, plasma BDNF levels have been used as a biomarker in several clinical studies [9][10][11]. In view of all these considerations, strategies that modulate peripheral levels of BDNF should be consider important tools among elderly.…”

Section: Introductionmentioning

confidence: 97%

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Elsner¹,

Trevizol²,

Bassôa³

et al. 2018

SDRP-JCMP

Self Cite

View full text Add to dashboard Cite

Background: Emerging evidences have been pointed out that exercise in combination with dietary factors is able to affect molecular events related to synaptic plasticity and cognitive improvement. Therefore, this study sought to verify the impact of grape juice consumption and/or exercise in plasma neurotrophic factor (BDNF) levels and memory performance in elderly women. Methods: Nineteen healthy elderly women were randomly distributed in two groups: Grape Juice Group (GJG, n=9) and Grape Juice + Exercise Group (GJEG, n=10). The GJG was instructed to drunk daily the grape juice (400 ml) for 30 days, while the GJEG was also submitted to a physical exercise intervention (twice a week, 60 min/session). Memory function was assessed via the MoCA (Montreal Cognitive Assessment) and blood sampling was taken for BDNF analysis pre/post intervention in both groups. Results: It was observed a significant increase on BDNF levels in GJG (p=0.000) and GJEG (p=0.041) after intervention, while the memory improvement was verified only in GJEG (p=0.024). No differences between groups were found in the variables. Conclusion: In conclusion, the grape juice consumption per se is capable to modulates/increases BDNF levels, response that was not potentiated by exercise practice. On the other hand, the memory performance was improved only when grape juice consumption is combined to exercise intervention in healthy elderly women.

show abstract

Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease

Aleksandrova,

Dimov,

Tacheva

et al. 2024

Medicina

View full text Add to dashboard Cite

Background and Objectives: One of the members of the neurotrophin (NT) family is the brain-derived neurotrophic factor (BDNF). In addition to its role in the nerve system, it has been found to play a role in lung health and diseases. Materials and Methods: The serum concentrations of BDNF were assessed in 57 patients with COPD and in 19 control individuals and the possible associations of BDNF with the spirometric indexes and disease stages were explored. Results: We did not find a significant difference between the serum concentrations of BDNF of patients and controls (p = 0.521). A significant negative correlation of the serum BDNF levels with the age of the patients (Rho = −0.279, p = 0.036) was observed. In addition, a borderline negative correlation with the age of disease onset (Rho= −0.244, p = 0.063) was also found. When analyzing these correlations in different genders, we found stronger statistical significance in male patients (Rho = −0.398, p = 0.009; and Rho = −0.419, p = 0.006), while no such significance was found in females (p = 0.574 and p = 0.342). The analyses of the possible relations of serum BDNF concentration with the spirometric parameters in the whole group of patients did not reveal any significance (p = 0.231 for FEV1%pr. and p = 0.271 for FEV1/FVC%). However, when the patients were dichotomized on the basis of smoking habits, we obtained a strong positive correlation between BDNF and FEV1%pr. (Rho = 0.501, p = 0.048) in non-smokers, but strong negative correlations with FEV1%pr. (Rho = −0.468, p = 0.003) and with FEV1/FVC% (Rho = −0.331, p = 0.040) in ex/current smokers. Non-smokers with moderate disease (GOLD II) had higher BDNF serum concentrations than patients with GOLD stage III/IV (p = 0.031). In ex/current smokers, there was an opposite association (p = 0.045). Conclusions: The results of our study suggest that the expression and secretion of BDNF are changed in COPD, but its effects and functions may differ according to the smoking history of the patients.

show abstract

Pulmonary rehabilitation and BDNF levels in patients with chronic obstructive pulmonary disease: A pilot study

Cited by 3 publications

References 57 publications

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Effect of 12-week pulmonary rehabilitation on cognitive function in patients with stable chronic obstructive pulmonary disease: study protocol for a single-center randomised controlled trial

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Smoking-Dependent Association of Serum Brain-Derived Neurotrophic Factor with Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease

Contact Info

Product

Resources

About