Pulmonary pleomorphic carcinoma metastasizing to the anterior mandibular gingiva: A case report and literature review

Kajita, Tomonari; Matsumoto, Hitoshi; Kitamura, Jun; Kouketsu, Atsumu; Kumamoto, Hiroyuki; Takahashi, Tsuneo

doi:10.1016/j.ijscr.2022.107499

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unconventional sites, such as the mandibular condyle or maxillary gingiva, can be colonized by the secondary spreading of primary cancer that can manifest with subtle or even without any symptoms [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer Cells Infiltration into a Mandibular Follicular Cyst

Marelli,

Ghizzoni,

Pellegrini

et al. 2023

Case Reports in Dentistry

View full text Add to dashboard Cite

Introduction. The oral cavity is a rare site for other organs’ tumor metastases. The incidence rate ranges from 1% to 3% of all oral malignancies. Metastases more frequently localize in the mandible, especially in the molar area. Metastases within odontogenic cysts are extremely rare, thus in the literature, only a few cases have been reported. The follicular cyst is one of the most frequent cysts of the jaws. Radiologically it shows as a unilocular lesion with a sclerotic border, characterized by a homogenous radiolucency that incorporates the crown of the unerupted tooth. Methods. A 76-year-old female patient, affected by stage IV of lung adenocarcinoma, reported pain on the left mandible border, alongside lip dysesthesia. The ortho-panoramic radiograph showed a follicular cyst in the posterior left side of the mandible, with involvement of the ascending branch region. The cyst was surgically removed together with the impacted tooth. A histopathological examination of the specimen confirmed the diagnostic suspect of a follicular cyst, but in the cystic wall, focal infiltration of epithelial neoplastic cells was also found. The immunohistochemical analysis showed the presence of three different markers: CK 7+, TTF1+/−, and P40−. These markers identify the cells as metastatic lung carcinoma. Results. Secondary tumor spreading in the jaws’ area is rare (3% of all malignant lesions). Despite odontogenic cysts can undergo a dysplastic transformation (affecting the epithelial covering in ≤1% of the cases), infrequently these neoplastic cells can be related to secondary tumor spreading in a cystic wall. This report describes a metastatic localization within a mandibular follicular cyst. Conclusions. Malignant cancers’ metastasis in the oral district remains a rare and unexplored condition, especially when metastases are located in odontogenic cysts. In this circumstance, surgical removal and histopathological examination are strongly recommended.

show abstract

Section: Discussionmentioning

confidence: 99%