Pulmonary Physiologic Changes of Morbid Obesity

Biring, Manmohan S.; Lewis, Michael I.; LIU, JOHN T.; Mohsenifar, Zab

doi:10.1097/00000441-199911000-00002

Cited by 212 publications

(196 citation statements)

References 17 publications

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“…Biring et al 22 also used spirometry in 43 morbidly obese patients and observed that ERV was significantly reduced due to obesity, a fact attributed to reduced pulmonary compliance, to the weight of the abdomen on the chest wall and to weakening of the respiratory musculature.…”

Section: Correlation Between Percent Loss Of Weight Excess and Pulmonmentioning

confidence: 99%

Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery

Xavier¹,

Ceneviva²,

Filho³

et al. 2010

Acta Cir. Bras.

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Purpose: To investigate the body weight, pulmonary function and quality of life of twenty patients with morbid obesity six months after the Fobi-Capella operation. Methods: Patients were evaluated before and six months after surgery. The patients were mainly female (75%), the average age was 40.5 ± 10.27 years; average weight 110.11 kg ± 21.77 and average body mass index (BMI) 39.93 ± 7.13 kg/m 2 in the postoperative evaluation. Pulmonary function was assessed by spirometry using a Pulmonet/Godart NV Bilt Vetr Hotland spirometer and quality of life was assessed by applying the Moorehead-Ardelt questionnaire. The pre-and postoperative spirometry values were compared by the paired Student t test and the correlation between weight loss and pulmonary function was determined by linear regression, with the level of significance set at p < 0.05. Results: The spirometry variables Respiratory Frequency (RF), Expiratory Reserve Volume (ERV) and Functional Residual Capacity (FRC) differed significantly between the pre-and postoperative periods, whereas Residual Volume (RV), Vital Capacity (VC), Total Lung Capacity (TLC), FEF (Forced Expiratory Flow between 25 and 75% FVC) and FEV1/FVC% (Forced Expiratory Volume in the 1 st second/ Forced Vital Capacity ratio) did not differ between periods. Only one patient reported worsening of quality of life. There was a positive correlation between weight loss and ERV (p=0.0117, r=0.5514), but no correlations were observed for the other variables. Conclusions: There was a significant weight loss and an improvement of pulmonary function as seen by respiratory frequency, reduction and increased expiratory reserve volume and functional residual capacity. The quality of life of the patients also improved after the Fobi-Capella operation. Key words: Obesity, Morbid. Respiratory Function Tests. Quality of Life. Bariatric Surgery. RESUMOObjetivo: Investigar a evolução do peso corpóreo, da função pulmonar e da qualidade de vida de 20 pacientes obesos mórbidos seis meses após operação de Fobi-Capella. Métodos: Os pacientes foram avaliados antes e seis meses após a cirurgia e o sexo feminino predominou em 75%, com média de idade de 40,5 anos ± 10, 27, média de peso de 110,11 kg ± 21,77 e IMC de 39,93 kg/m 2 ± 7,13. Para a avaliação da função pulmonar foi realizada espirometria por meio do espirômetro Pulmonet Godart NV Bilt Vetr Holland, e para a qualidade de vida foi aplicado o questionário de Moorehead-Ardelt. As comparações entre os valores espirométricos do pré e do pós-operatório foram realizadas pelo teste t de Student para amostras pareadas, e para a correlação entre a perda de peso e função pulmonar utilizou-se análise de regressão linear simples, adotando-se p < 0,05 para todos os resultados. Resultados: As variáveis espirométricas Freqüência Respiratória (FR), Volume de Reserva Expiratório (VRE) e Capacidade Residual Funcional (CRF) apresentaram, aos seis meses após a operação, diferença estatisticamente significativa com os valores pré-operatórios, porém, não houve diferença ...

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Section: Correlation Between Percent Loss Of Weight Excess and Pulmonmentioning

confidence: 99%

Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery

Xavier¹,

Ceneviva²,

Filho³

et al. 2010

Acta Cir. Bras.

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“…[4][5][6][7][8][9][10] The most frequent pulmonary function tests (PFTs) findings are reduced expiratory reserve volume (ERV), functional residual capacity (FRC) and total lung capacity (TLC), [4][5][6]9 which are generally related to alterations in chest wall mechanics induced by an increased abdominal load. 8 These alterations reduce total respiratory compliance.…”

Section: (Ohs)mentioning

confidence: 99%

Physiologic correlates of dyspnea in patients with morbid obesity

et al. 2006

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Objective: Mechanisms of dyspnea in obesity remain unclear. This study was undertaken to determine the relationships between dyspnea and pulmonary function including inspiratory muscle endurance (IME) in morbidly obese patients before bariatric surgery. Research methods and procedures: Fifty-five patients with a mean7s.d. body mass index (BMI) of 49.477.0 kg/m 2 were included. Dyspnea was evaluated by the Baseline Dyspnea Index (BDI; 0-12, 0 ¼ maximal dyspnea). Pulmonary function tests included a plethysmography, maximal inspiratory pressure (PImax) and IME was assessed by the incremental threshold loading test, determining the maximal pressure sustained for 2 min (Plim 2 ) and Plim 2 /PImax ratio. Patients were classified according to their BMI in two groups: BMI p49 (n ¼ 27) and 449 kg/m 2 (n ¼ 28

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“…obesity on respiratory disease, there are clear effects on pulmonary function [3,4]. Cross-sectional studies have demonstrated an inverse relationship between forced expiratory volume in 1 s (FEV 1 ) and both BMI and waist circumference [5,6]. This is of particular importance because FEV 1 is an independent predictor of all-cause mortality and a strong risk factor for cardiovascular disease, stroke and lung cancer [7].…”

Section: Introductionmentioning

confidence: 99%

Type 2 diabetes impairs pulmonary function in morbidly obese women: a case–control study

et al. 2010

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Aims/hypothesis To determine whether the presence of type 2 diabetes and the degree of metabolic control are related to reduced pulmonary function in obese individuals. Conclusions/interpretation The presence of diabetes and the degree of glycaemic control are related to respiratory function impairment in morbidly obese women. Therefore, the impact of type 2 diabetes on pulmonary function should be taken into consideration by those providing care for obese people.

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Pulmonary Physiologic Changes of Morbid Obesity

Abstract: Extreme obesity is associated with a reduction in ERV, FVC, FEV1, FRC, FEF25-75%, and MVV. However, contrary to prior reports, D(LCO) is not elevated. These effects are only partially explained by smoking.

Cited by 212 publications

References 17 publications

Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery

Pulmonary function and quality of life in patients with morbid obesity six months after bariatric surgery

Physiologic correlates of dyspnea in patients with morbid obesity

Type 2 diabetes impairs pulmonary function in morbidly obese women: a case–control study

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