Pulmonary outcomes in adults with a history of Bronchopulmonary Dysplasia differ from patients with asthma

Abstract

Background Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in adulthood. Despite the differences in underlying pathology, patients with a history of BPD are often treated as asthmatics. We hypothesized that pulmonary outcomes and health-related quality of life (HRQoL) were different in adults born preterm with and without a history of BPD compared to asthmatics and healthy individuals. Methods We evaluated 96 young adults from the LUNAPRE cohort ( clinicaltrials.gov/ct2/show/NCT02923648 ), including 26 individuals born preterm with a history of BPD (BPD), 23 born preterm without BPD (preterm), 23 asthmatics and 24 healthy controls. Extensive lung function testing and HRQoL were assessed. Results The BPD group had more severe airway obstruction compared to the preterm-, (FEV 1− 0.94 vs. 0.28 z-scores; p ≤ 0.001); asthmatic- (0.14 z-scores, p ≤ 0.01) and healthy groups (0.78 z-scores, p ≤ 0.001). Further, they had increased ventilation inhomogeneity compared to the preterm- (LCI 6.97 vs. 6.73, p ≤ 0.05), asthmatic- (6.75, p = 0.05) and healthy groups (6.50 p ≤ 0.001). Both preterm groups had lower D LCO compared to healthy controls ( p ≤ 0.001 for both). HRQoL showed less physical but more psychological symptoms in the BPD group compared to asthmatics. Conclusions Lung function impairment and HRQoL in adults with a history of BPD differed from that in asthmatics highlighting the need for objective assessment of lung health. Electronic supplementary material The online version of this article (10.1186/s12931-019-1075-1) contains supplementary material, which is available to authorized users.

Respiratory outcomes of “new” bronchopulmonary dysplasia in adolescents: A multicenter study

“…Lung parenchymal injury and vascular disease should lead to a more significant decline in diffusion capacity in patients with BPD. However, as observed in our study, diffusion capacity does not always differ between EP patients with and without BPD 18,24 ; in addition, changes in the diffusion capacity tend to persist over time 31 …”

Diverging effects of premature birth and bronchopulmonary dysplasia on exercise capacity and physical activity – a case control study

“…This is in line with our data, where the BPD group showed lower peak oxygen uptake and at the same time lower peak tidal volume, possibly reflecting altered breathing mechanisms. There is ample evidence that children born preterm show decrements in lung function (reduced FEV1, FVC, TLCO) [17, 34] and those with BPD are affected even more [16, 17, 35, 36], which may result in reduced exercise capacity [37]. We also observed an impairment in diffusion capacity in the BPD and the No-BPD groups.…”

“…During childhood, BPD has been associated with bronchial obstruction and reduced diffusion capacity [3, 5, 12, 15]. Lung function impairment may persist into adult age [16, 17]. Thus, BPD affects health beyond the neonatal period and is relevant for long term outcome after extreme prematurity [16].…”

High-Precision Automated Workflow for Urinary Untargeted Metabolomic Epidemiology

“…The method was characterized using fasting urine samples ( n = 87) from subjects from the LUNg obstruction in Adulthood of PREmaturely born (LUNAPRE) study ( ClinicalTrials.gov NCT02923648). 23 Stability assessments were performed using pooled urine from all individuals (hereafter referred to as pooled study quality control sample, SQC) as well as internal laboratory reference urine from healthy volunteers (pooled laboratory reference quality control, RQC). Proof-of-concept studies for large-scale application were performed using urine samples from a rhinovirus challenge study ( n = 842; Netherlands Trial Register NTR5426/NL5317).…”